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A Highly Pathogenic #Avian #H7N9 #Influenza Virus Isolated from A #Human Is Lethal in Some #Ferrets Infected via #Respiratory #Droplets (Cell Host Microbe, abstract)

Title : A Highly Pathogenic #Avian #H7N9 #Influenza Virus Isolated from A #Human Is Lethal in Some #Ferrets Infected via #Respiratory #Drop...

18 Sep 2017

#China–#Influenza [#H1N1pdm09, #H3N2, B, #H7N9] Weekly #Report - Week 36 – September 18 2017 (CNIC, edited)


Title: #China–#Influenza [#H1N1pdm09, #H3N2, B, #H7N9] Weekly #Report - Week 36 – September 18 2017.

Subject: Human and Animal Influenza Viruses, A & B types, current situation in China.

Source: National Influenza Centre, China, full page: (LINK).

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China - Influenza Weekly Report - Week 36 – September 18 2017

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(All data are preliminary and may change as more reports are received)


Summary

  • During week 36, influenza activity level was very high in most provinces in southern China, and was low with increasing trend in northern China. A(H3N2) was the dominant strain nationwide.
  • Among influenza viruses antigenically characterized by CNIC since September, 2016:
    • 1508(99.6%) influenza A(H1N1)pdm09 viruses were characterized as A/California/7/2009-like;
      • 1393(92.8%) influenza A(H1N1)pdm09 viruses were characterized as A/Michigan/45/2015-like;
    • 377(40.7%) influenza A(H3N2) viruses were characterized as A/Hong Kong/4801/2014 (H3N2)(EGG)-like,
    • 902(97.3%) influenza A(H3N2) viruses were characterized as A/Hong Kong/4801/2014 (H3N2)(CELL)-like;
    • 740(90.6%) influenza B/Victoria viruses were characterized as B/Brisbane/60/2008-like;
    • 255(92.4%) influenza B/Yamagata viruses were characterized as B/Phuket/3073/2013-like.
  • Among the influenza viruses tested by CNIC for antiviral resistance analysis since September, 2016:
    • all influenza A(H1N1)pdm09 and all influenza A(H3N2) viruses were resistant to adamantine;
    • All influenza H3N2 and B viruses were sensitive to neuraminidase inhibitors.
    • All but 4 influenza A(H1N1)pdm09 viruses were sensitive to neuraminidase inhibitors.


Outbreak Surveillance

  • During week 36 (Sep4-Sep10 ), there were three outbreaks reported nationwide, one of them was A(H1N1)pdm09, the other two have not yet identified the nature.


Surveillance of outpatient or emergency visits for Influenza-like Illness (ILI)

  • During week 36, the percentage of outpatient or emergency visits for ILI (ILI %) at national sentinel hospitals in southern China was 3.1%, lower than the last week (3.2%), higher than the same week of 2014-2016(2.6%, 2.8%, 2.6%).(Figure 1)
  • During week 36, ILI% at national sentinel hospitals in northern China was 2.5%, higher than the last week and the same week of 2015 and 2016(2.4%, 2.4%, 2.2%), same as the same week of 2014 (2.5%). (Figure 2)

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Figure 1. Percentage of Visits for ILI at Sentinel Hospitals in South China (2014-2018)

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Figure 2. Percentage of Visits for ILI at Sentinel Hospitals in North China (2014-2018)

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Virologic Surveillance

  • During week 36, influenza network laboratories tested 2190 specimens, of which 434(19.8%) were positive for influenza, influenza A and influenza B viruses were 417(96.1%) and 17 (3.9%), respectively (Table 1).
  • During week 36, the percentage of specimens that were tested positive for influenza in south China was 23.9%, which was lower than the previous week (26.9%) (Figure 3).
  • During week 36, the percentage of specimens that were tested positive for influenza in north China was 6.5%, which was lower than the previous week (8.1%). (Figure 4).


Table 1 Laboratory Detections of ILI Specimens (Week 36, 2017)

[Week 36 - South China - North China – Total]

  • No. of specimens tested – 1681 – 509 – 2190
    • No. of positive specimens (%) - 401(23.9%) - 33(6.5%) - 434(19.8%)
      • Influenza A - 385(96.0%) - 32(97.0%) - 417(96.1%)
        • A(H3N2) - 378(98.2%) - 32(100%) - 410(98.3%)
        • A(H1N1)pdm09 - 7(1.8%) - 0(0) - 7(1.7%)
        • A (subtype not determined) - 0(0) - 0(0) - 0(0)
      • Influenza B - 16(4.0%) - 1(3%) - 17(3.9%)
        • B (lineage not determined) - 1(6.3%) - 0(0) - 1(5.9%)
        • Victoria - 10(62.5%) - 0(0) - 10(58.8%)
        • Yamagata - 5(31.3%) - 1(100%) - 6(35.3%)

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Figure 3. Influenza Positive Tests Reported by Southern Network Laboratories (Week 14, 2016–Week 36, 2017)

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Note: Analysis in this part was based on the test results of network laboratories. If it were not consistent with the results of CNIC confirmation, the results of CNIC confirmation were used.

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Figure 4. Influenza Positive Tests Reported by Northern Network Laboratories (Week 14, 2016–Week 36, 2017)

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Note: Analysis in this part was based on the result of network laboratories. If it were not consistent with the results of CNIC confirmation, the results of CNIC confirmation were used.

(…)


H7N9 case report

  • Since the notification of human infection with novel reassortant influenza A(H7N9) virus on 31 March 2013, in total 1561 laboratory-confirmed cases have been reported to WHO.
  • Among 758 cases reported in fifth wave (Since Oct 2016), 28 cases were infected with HPAI A(H7N9) virus, which have mutations in the hemagglutinin gene indicating a change to high pathogenicity in poultry.
  • These 28 cases are from Taiwan (the case had travel history to Guangdong), Guangxi, Guangdong, Hunan, Shaanxi and Hebei provinces, with illness onset date before July 2017.
  • No increased transmissibility or virulence to human case was detected in the HPAI A(H7N9) virus.

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|-- Download:China flu report 1736.pdf –|

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Keywords: China; Updates; Avian Influenza; Seasonal Influenza; Human; H1N1pdm09; H3N2; B; H7N9.

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