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#Avian #Influenza #H7N9 in #China: Preventing the Next #SARS (@WHO, Apr. 2 ‘17)

  Title : #Avian #Influenza #H7N9 in #China: Preventing the Next #SARS. Subject : Avian Influenza, H7N9 subtype (Asian Lineage), poultry e...

7 Aug 2017

#China, #Influenza [#H3N2, #H1N1pdm09, B, #H7N9] Weekly #Report - Week 30 2017 – As of August 8 ‘17 (CNIC, edited)


Title: #China, #Influenza [#H3N2, #H1N1pdm09, B, #H7N9] Weekly #Report - Week 30 2017 – As of August 8 ‘17.

Subject: Human and Animal Influenza Viruses, H1, H3, H7N9 subtypes, activity surveillance in China, weekly report.

Source: China National Influenza Centre, full page: (LINK).

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China, Influenza Weekly Report - Week 30 2017 – As of August 8 ‘17

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(All data are preliminary and may change as more reports are received)


Summary

  • During week 30, influenza activity increased or peaked in most provinces in southern China, A(H3N2) was the dominant strain, but almost no influenza activity was detected in northern China.
  • Among influenza viruses antigenically characterized by CNIC since September, 2016:
    • 1361(99.6%) influenza A(H1N1)pdm09 viruses were characterized as A/California/7/2009-like;
    • 1326(98.0%) influenza A(H1N1)pdm09 viruses were characterized as A/Michigan/45/2015-like;
    • 365(41.0%) influenza A(H3N2) viruses were characterized as A/Hong Kong/4801/2014 (H3N2)(EGG)-like,
    • 868(97.5%) influenza A(H3N2) viruses were characterized as A/Hong Kong/4801/2014 (H3N2)(CELL)-like;
    • 723(91.3%) influenza B/Victoria viruses were characterized as B/Brisbane/60/2008-like;
    • 238(91.9%) influenza B/Yamagata viruses were characterized as B/Phuket/3073/2013-like.
  • Among the influenza viruses tested by CNIC for antiviral resistance analysis since September, 2016:
    • all influenza A(H1N1)pdm09 and all influenza A(H3N2) viruses were resistant to adamantine;
    • All influenza H3N2 and B viruses were sensitive to neuraminidase inhibitors.
    • All but 4 influenza A(H1N1)pdm09 viruses were sensitive to neuraminidase inhibitors.


Outbreak Surveillance

  • During week 30 (Jul 24- Jul 30 2017), there were ten outbreaks reported nationwide, six of them were A(H3N2),three of them were untyped, one of them was A( unsubtyped).


Surveillance of outpatient or emergency visits for Influenza-like Illness (ILI)

  • During week 30, the percentage of outpatient or emergency visits for ILI (ILI %) at national sentinel hospitals in southern China was 4.0%, lower than the last week (4.1%), higher than the same time of 2014-2016(3.5%, 3.6%, 3.1%).(Figure 1)
  • During week 30 ILI% at national sentinel hospitals in northern China was 2.4%, lower than the last week and the same of 2014(both2.5%), same as the same week of 2015(2.4%), higher than the same week of 2016(2.3%). (Figure 2)


Figure 1. Percentage of Visits for ILI at Sentinel Hospitals in South China (2014-2018)

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Figure 2. Percentage of Visits for ILI at Sentinel Hospitals in North China (2014-2018)

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Virologic Surveillance

  • During week 30, influenza network laboratories tested 3797 specimens, of which 664(17.5%) were positive for influenza, influenza A and influenza B viruses were 622(93.7%) and 42 (6.3%), respectively (Table 1).
  • During week 30, the percentage of specimens that were tested positive for influenza in south China was 22.5%, which was slightly lower than the previous week (23.0%) (Figure 3).
  • During week 30, the percentage of specimens that were tested positive for influenza in north China was 1.1%, which was slightly lower than the previous week (1.3%). (Figure 4).


Table 1 Laboratory Detections of ILI Specimens (Week 30, 2017)

[Week 30 - South China: - North China: Total]

  • No. of specimens tested  - 2911 – 886 – 3797
    • No. of positive specimens (%) - 654(22.5%) - 10(1.1%) - 664(17.5%)
      • Influenza A - 612(93.6%) - 10(100%) - 622(93.7%)
        • A(H3N2) - 574(93.8%) - 9(90.0%) - 583(93.7%)
        • A(H1N1)pdm09 - 38(6.2%) - 1(10.0%) - 39(6.3%)
        • A (subtype not determined) - 0(0) - 0(0) - 0(0)
      • Influenza B  - 42(6.4%) - 0(0) - 42(6.3%)
        • B (lineage not determined) - 6(14.3%) - 0(0) - 6(14.3%)
        • Victoria - 20(47.6%) - 0(0) - 20(47.6%)
        • Yamagata - 16(38.1%) - 0(0) - 16(38.1%)

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Figure 3. Influenza Positive Tests Reported by Southern Network Laboratories (Week 14, 2016–Week 30, 2017)

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Note: Analysis in this part was based on the test results of network laboratories. If it were not consistent with the results of CNIC confirmation, the results of CNIC confirmation were used.

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Figure 4. Influenza Positive Tests Reported by Northern Network Laboratories (Week 14, 2016–Week 30, 2017)

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Note: Analysis in this part was based on the result of network laboratories. If it were not consistent with the results of CNIC confirmation, the results of CNIC confirmation were used.

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Antigenic Characterization

  • Since September 1st, 2016, 1361(99.6%) of the 1366A(H1N1)pdm09 viruses tested were characterized as A/California/7/2009-like; 1326(98.0%) of the 1353 A(H1N1)pdm09 viruses tested were characterized as A/Michigan/45/2015-like;365(41.0%) of the 890A(H3N2)influenza viruses tested were characterized as A/Hong Kong/4801/2014 (H3N2)(EGG)-like, 868(97.5%) of the 890A(H3N2) influenza viruses tested were characterized as A/Hong Kong/4801/2014 (H3N2)(CELL)-like; 723(91.3%) of the 792 influenza B/Victoria lineage viruses tested were characterized as B/Brisbane/60/2008-like; 238(91.9%) of the 259 influenza B/Yamagata lineage viruses tested were characterized as B/Phuket/3073/2013-like.


Antiviral Resistance

  • Since September 1st, 2016, among the influenza viruses tested by CNIC for antiviral resistance, all influenza A(H1N1)pdm09 and all influenza A(H3N2) viruses were resistant to adamantine ; All influenza A(H3N2) and B viruses were sensitive to neuraminidase inhibitors. All but 4 influenza A(H1N1)pdm09 viruses were sensitive to neuraminidase inhibitors.


H7N9 case report

  • Since the notification of human infection with novel reassortant influenza A(H7N9) virus on 31 March 2013, in total 1554 laboratory-confirmed cases have been reported to WHO.
  • Among 750 cases reported in fifth wave (Since Oct 2016), 25 cases were infected with HPAI A(H7N9) virus, which have mutations in the hemagglutinin gene indicating a change to high pathogenicity in poultry.
  • These 25 cases are from Taiwan (the case had travel history to Guangdong), Guangxi, Guangdong and Hunan provinces, with illness onset date before April 2017.
  • No increased transmissibility or virulence to human case was detected in the HPAI A(H7N9) virus.

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|-- Download:China flu report 1730.pdf –|

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Keywords: China; Updates; Seasonal Influenza; Avian Influenza; Human; H1N1pdm09; H3N2; Influenza B; H7N9.

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