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#Update: Increase in #Human #Infections with #Avian #Influenza #H7N9 Viruses During the 5th #Epidemic — #China, Oct. ‘16–Aug. 7 ‘17 (@CDCgov, edited)

Title : #Update: Increase in #Human #Infections with #Avian #Influenza #H7N9 Viruses During the 5th #Epidemic — #China, Oct. ‘16–Aug. 7 ‘17....

10 May 2017

#Zika Virus #Research – #Journals’ #Archives #Scanning–May 10 2017 #Update (WWS)

 

Title: #Zika Virus #Research – #Journals’ #Archives #Scanning–May 10 2017 #Update.

Subject: Zika Virus Infection and related complications, deep web scanning for Journals’ Archives.

Source: WorldWideScience.org, full page: (LINK).

Code: [  R  ]

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See more at –> WorldWideScience.org - Alerts for 2017-05-10

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New Entries:

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      • Dub T; Fontanet A.
      • 2017-05-01  Revue neurologique
      • DOI: 10.1016/j.neurol.2017.03.033  ISSN: 0035-3787  PMID: 28483386
      • Boigard H; Alimova A; Martin GR; Katz A; Gottlieb P; Galarza JM.
      • 2017-05-01  PLoS neglected tropical diseases
      • DOI: 10.1371/journal.pntd.0005608  ISSN: 1935-2727  Volume: 11  Issue: 5  Pages: e0005608  PMID: 28481898
        • The newly emerged mosquito-borne Zika virus poses a major public challenge due to its ability to cause significant birth defects and neurological disorders. The impact of sexual transmission is unclear but raises further concerns about virus dissemination. No specific treatment or vaccine is currently available, thus the development of a safe and effective vaccine is paramount. Here we describe a novel strategy to assemble Zika virus-like particles (VLPs) by co-expressing the structural (CprME) and non-structural (NS2B/NS3) proteins, and demonstrate their effectiveness as vaccines. VLPs are produced in a suspension culture of mammalian cells and self-assembled into particles closely resembling Zika viruses as shown by electron microscopy studies. We tested various VLP vaccines and compared them to analogous compositions of an inactivated Zika virus (In-ZIKV) used as a reference. VLP immunizations elicited high titers of antibodies, as did the In-ZIKV controls. However, in mice the VLP vaccine stimulated significantly higher virus neutralizing antibody titers than comparable formulations of the In-ZIKV vaccine. The serum neutralizing activity elicited by the VLP vaccine was enhanced using a higher VLP dose and with the addition of an adjuvant, reaching neutralizing titers greater than those detected in the serum of a patient who recovered from a Zika infection in Brazil in 2015. Discrepancies in neutralization levels between the VLP vaccine and the In-ZIKV suggest that chemical inactivation has deleterious effects on neutralizing epitopes within the E protein. This along with the inability of a VLP vaccine to cause infection makes it a preferable candidate for vaccine development.
      • 2017-05-09  EPA Pesticide Factsheets
        • ... BG-Sweetscent attracts mosquitoes, including those which may (transmit) (carry) (West Nile virus) (encephalitis) (Zika virus) (Chikungunya virus ...

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Keywords: Research; Abstracts; Zika Virus; WWS.

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