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#Update: Increase in #Human #Infections with #Avian #Influenza #H7N9 Viruses During the 5th #Epidemic — #China, Oct. ‘16–Aug. 7 ‘17 (@CDCgov, edited)

Title : #Update: Increase in #Human #Infections with #Avian #Influenza #H7N9 Viruses During the 5th #Epidemic — #China, Oct. ‘16–Aug. 7 ‘17....

10 May 2017

#Influenza A #H7N9 #Research, #Journals’ #Archives Scanning, May 10 2017 #Update (WWS)

 

Title: Influenza A H7N9 Research, Journals’ Archives Scanning, May 10 2017 Update.

Subject: Avian Influenza, H7N9 subtype, poultry enzootic and human cases, research.

Source: WorldWideScience.org, full page: (LINK).

Code: [  R  ]

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See more at –> WorldWideScience.org - Alerts for 2017-05-10

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New Entries:

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      • Zhang ZH; Meng LS; Kong DH; Liu J; Li SZ; Zhou C; Sun J; Song RJ; Wu JJ.
      • 2017-05-01  Chinese medical journal
      • DOI: 10.4103/0366-6999.205849  ISSN: 0366-6999  Volume: 130  Issue: 10  Pages: 1255-1256  PMID: 28485329
      • Influenza A virus (A/blue-winged teal/Louisiana/UGAI15-1367/2015(H7N9)) segment 4 hemagglutinin (HA) gene, complete cds.
      • Influenza A virus (A/blue-winged teal/Louisiana/UGAI15-1367/2015(H7N9)) segment 6 neuraminidase (NA) gene, complete cds.
      • Influenza A virus (A/blue-winged teal/Louisiana/UGAI15-1692/2015(H7N9)) segment 1 polymerase PB2 (PB2) gene, complete cds.
      • Influenza A virus (A/blue-winged teal/Louisiana/UGAI15-1367/2015(H7N9)) segment 1 polymerase PB2 (PB2) gene, complete cds.
      • Influenza A virus (A/blue-winged teal/Louisiana/UGAI15-1367/2015(H7N9)) segment 5 nucleocapsid protein (NP) gene, complete cds.
      • Jia, Weixin; Cao, Chenfu; Lin, Yanxing; Zhong, Liangning; Xie, Shumin; Wang, Xiao; Yin, Sanhong; Xu, Zhenna; Dai, Yixue; Li, Zhixian; Niu, Xiao; Qi, Wenbao; Lu, Tikang; Liao, Ming
      • 2017-04-12  PubMed
      • DOI: 10.1016/j.jviromet.2017.03.014  Volume: 246  Pages: 100-103
      • Keywords: H7N9, Highly pathogenic H7 virus, rRT-PCR
        • On February 19, 2017, China announced that the mutant H7N9 virus appeared in human cases, which showed molecular characteristic of highly pathogenic virus for poultry. In this study, a duplex real-time reverse transcription polymerase chain reaction (rRT-PCR) assay was developed for distinguish between highly pathogenic H7 virus and low pathogenic H7 virus. The sensitivity, specificity, stability and conformance tests were conducted for this method. The data showed that the new method is sensitive. The minimum detection limit for the RNA of highly pathogenic H7 virus is 0.0052fg and the minimum detection limit for the RNA of low pathogenic H7 virus is 0.36fg. The method gave specific results in detecting novel highly pathogenic H7 virus and will play an important role in the rapid identification of novel highly pathogenic H7 virus. Copyright © 2017. Published by Elsevier B.V.
      • Jia W; Cao C; Lin Y; Zhong L; Xie S; Wang X; Yin S; Xu Z; Dai Y; Li Z; Niu X; Qi W; Lu T; Liao M.
      • 2017-04-01  Journal of virological methods
      • DOI: 10.1016/j.jviromet.2017.03.014  ISSN: 0166-0934  Volume: 246  Pages: 100-103  PMID: 28411129
        • On February 19, 2017, China announced that the mutant H7N9 virus appeared in human cases, which showed molecular characteristic of highly pathogenic virus for poultry. In this study, a duplex real-time reverse transcription polymerase chain reaction (rRT-PCR) assay was developed for distinguish between highly pathogenic H7 virus and low pathogenic H7 virus. The sensitivity, specificity, stability and conformance tests were conducted for this method. The data showed that the new method is sensitive. The minimum detection limit for the RNA of highly pathogenic H7 virus is 0.0052fg and the minimum detection limit for the RNA of low pathogenic H7 virus is 0.36fg. The method gave specific results in detecting novel highly pathogenic H7 virus and will play an important role in the rapid identification of novel highly pathogenic H7 virus.
      • Hilgers, Luuk A Th; Platenburg, Peter Paul L I; Bajramovic, Jeffrey; Veth, Jennifer; Sauerwein, Robert; Roeffen, Will; Pohl, Marie; van Amerongen, Geert; Stittelaar, Koert J; van den Bosch, Johannes F
        • 2017-05-04  PubMed
        • DOI: 10.1016/j.vaccine.2017.04.055
        • Keywords: TLR4, Vaccine adjuvants, ferrets, influenza, rabbits, synthetic carbohydrate derivatives
          • Carbohydrate fatty acid sulphate esters (CFASEs) formulated in a squalane-in-water emulsion are effective adjuvants for humoral responses to a wide range of antigens in various animal species but rise in body temperature and local reactions albeit mild or minimal hampers application in humans. In rabbits, body temperature increased 1°C one day after intramuscular (IM) injection, which returned to normal during the next day. The effect increased with increasing dose of CFASE but not with the number of injections (up to 5). Antigen enhanced the rise in body temperature after booster immunization (P100-fold after the second immunization. In ferrets immunized with 7.5μg of inactivated influenza virus A/H7N9, CMS adjuvant gave 100-fold increase in HAI antibody titres after the first and 25-fold after the second immunisation, which were 10-20-fold higher than with the MF59-like AddaVax adjuvant. In both models, a single immunisation with CMS adjuvant revealed similar or higher titres than two immunisations with either benchmark, without detectable systemic and local adverse effects. Despite striking chemical similarities with monophospholipid A (MPL), CMS adjuvant did not activate human TLR4 expressed on HEK cells. We concluded that the synthetic CMS adjuvant is a promising candidate for poor immunogens and single-shot vaccines and that rise in body temperature, local reactions or activation of TLR4 is not a pre-requisite for high adjuvanticity. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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Keywords: Research; Abstracts; WWS; Avian Influenza; H7N9.

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