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#Update: Increase in #Human #Infections with #Avian #Influenza #H7N9 Viruses During the 5th #Epidemic — #China, Oct. ‘16–Aug. 7 ‘17 (@CDCgov, edited)

Title : #Update: Increase in #Human #Infections with #Avian #Influenza #H7N9 Viruses During the 5th #Epidemic — #China, Oct. ‘16–Aug. 7 ‘17....

29 Apr 2017

#Zika Virus Persists in the #CNS and #lymphnodes of Rhesus #Monkeys (#NIH, Apr. 29 ‘17)

 

Title: #Zika Virus Persists in the #CNS and #lymphnodes of Rhesus #Monkeys.

Subject: Zika Virus Infection, Rhesus Monkey animal’s model viral pathology research.

Source: US National Institute of Health, full page: (LINK).

Code: [  R  ]

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U.S. Department of Health and Human Services  / NATIONAL INSTITUTES OF HEALTH NIH News / National Institute of Allergy and Infectious Diseases (NIAID)

For Immediate Release: Friday, April 28, 2017 / CONTACT: NIAID Office of Communications, 301-402-1663, <e-mail:niaidnews@niaid.nih.gov>

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ZIKA VIRUS PERSISTS IN THE CENTRAL NERVOUS SYSTEM AND LYMPH NODES OF RHESUS MONKEYS

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Virus found in tissues weeks after clearance from blood

 

Zika virus can persist in cerebrospinal fluid (CSF), lymph nodes and colorectal tissue of infected rhesus monkeys for weeks after the virus has been cleared from blood, urine and mucosal secretions, according to a study published online today in Cell. The research was led by Dan H. Barouch, M.D., Ph.D., and colleagues at Beth Israel Deaconess Medical Center and Harvard Medical School and was funded in part by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

Investigators infected 20 rhesus monkeys with Zika virus and noted that although virus was cleared from peripheral blood within 7-10 days, they detected Zika virus in CSF for up to 42 days and in lymph nodes and colorectal biopsies for up to 72 days.

Immunologic data showed that the emergence of Zika virus-specific neutralizing antibodies correlated with the rapid control of the virus in plasma.

However, Zika-specific antibodies were not detected in CSF, which could be why the virus remained in CSF longer.

The authors also found that viral persistence in CSF correlated with the activation of the mechanistic target of rapamycin (mTOR) pathway, which has been shown to be related to the development of brain tissue and brain malformations.

The findings suggest that persistent virus in the central nervous system may contribute to the neurological issues associated with Zika virus infection in people, the authors note.

Although Zika virus usually causes mild or no symptoms in people, it has been associated with neurological disorders in children and adults and can cause severe fetal defects, such as microcephaly, if an infected pregnant woman passes the virus to her fetus.

The authors note it is possible that if the virus can persist in the central nervous system and other tissues in humans with Zika infection, more extensive neurologic and lymphoid disease than currently appreciated may be occurring.

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NIAID conducts and supports research -- at NIH, throughout the United States, and worldwide  -- to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID website.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs.

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Keywords: Research; Zika Virus; Neurology.

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