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Title : #Update: Increase in #Human #Infections with #Avian #Influenza #H7N9 Viruses During the 5th #Epidemic — #China, Oct. ‘16–Aug. 7 ‘17....

4 Nov 2016

#Investigation of the First Seven Reported Cases of #Candida_auris, an Emerging Invasive, MDR #Fungus — #USA, 05 2013–08 2016 (@CDCgov)


Title: #Investigation of the First Seven Reported Cases of #Candida_auris, an Emerging Invasive, MDR #Fungus — #USA, 05 2013–08 2016.

Subject: Candida Auris, first reported cases in the US.

Source: US Centers for Disease Control and Prevention (CDC), MMWR Morbidity and Mortality Weekly Report, full page: (LINK). Abstract.

Code: [     ]


Investigation of the First Seven Reported Cases of Candida auris, a Globally Emerging Invasive, Multidrug-Resistant Fungus — United States, May 2013–August 2016


Early Release / November 4, 2016 / 65

Format: [ PDF [121 KB] ]

Snigdha Vallabhaneni, MD1; Alex Kallen, MD2; Sharon Tsay, MD1,3; Nancy Chow, PhD1; Rory Welsh, PhD1; Janna Kerins, VMD3,4; Sarah K. Kemble, MD4; Massimo Pacilli, MS4; Stephanie R. Black, MD4; Emily Landon, MD5; Jessica Ridgway, MD5; Tara N. Palmore, MD6; Adrian Zelzany, PhD6; Eleanor H. Adams, MD7; Monica Quinn, MS7; Sudha Chaturvedi, PhD7; Jane Greenko, MPH7; Rafael Fernandez, MPH7; Karen Southwick, MD7; E. Yoko Furuya, MD8; David P. Calfee, MD9; Camille Hamula, PhD10; Gopi Patel, MD10; Patricia Barrett; MSD11; Patricia Lafaro12; Elizabeth L. Berkow, PhD1; Heather Moulton-Meissner, PhD2; Judith Noble-Wang, PhD2; Ryan P. Fagan, MD2; Brendan R. Jackson, MD1; Shawn R. Lockhart, PhD1; Anastasia P. Litvintseva, PhD1; Tom M. Chiller, MD1



  • What is already known about this topic?
    • Candida auris is an emerging pathogenic fungus that has been reported from at least a dozen countries on four continents during 2009–2015.
    • The organism is difficult to identify using traditional biochemical methods, some isolates have been found to be resistant to all three major classes of antifungal medications, and C. auris has caused health care–associated outbreaks.
  • What is added by this report?
    • This is the first description of C. auris cases in the United States.
    • C. auris appears to have emerged in the United States only in the last few years, and U.S. isolates are related to isolates from South America and South Asia.
    • Evidence from U.S. case investigations suggests likely transmission of the organism occurred in health care settings.
  • What are the implications for public health practice?
    • It is important that U.S. laboratories accurately identify C. auris and for health care facilities to implement recommended infection control practices to prevent the spread of C. auris.
    • Local and state health departments and CDC should be notified of possible cases of C. auris and of isolates of C. haemulonii and Candida spp. that cannot be identified after routine testing.



Candida auris, an emerging fungus that can cause invasive infections, is associated with high mortality and is often resistant to multiple antifungal drugs. C. auris was first described in 2009 after being isolated from external ear canal discharge of a patient in Japan (1). Since then, reports of C. auris infections, including bloodstream infections, have been published from several countries, including Colombia, India, Israel, Kenya, Kuwait, Pakistan, South Africa, South Korea, Venezuela, and the United Kingdom (27). To determine whether C. auris is present in the United States and to prepare for the possibility of transmission, CDC issued a clinical alert in June 2016 informing clinicians, laboratorians, infection control practitioners, and public health authorities about C. auris and requesting that C. auris cases be reported to state and local health departments and CDC (8). This report describes the first seven U.S. cases of C. auris infection reported to CDC as of August 31, 2016. Data from these cases suggest that transmission of C. auris might have occurred in U.S. health care facilities and demonstrate the need for attention to infection control measures to control the spread of this pathogen.



Keywords: USA; US CDC; Updates; Candida Auris; Nosocomial Outbreaks.