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#Update: Increase in #Human #Infections with #Avian #Influenza #H7N9 Viruses During the 5th #Epidemic — #China, Oct. ‘16–Aug. 7 ‘17 (@CDCgov, edited)

Title : #Update: Increase in #Human #Infections with #Avian #Influenza #H7N9 Viruses During the 5th #Epidemic — #China, Oct. ‘16–Aug. 7 ‘17....

4 Nov 2016

#Influenza virus #characterisation, #Summary #Europe, September 2016 04 Nov 2016 (@ECDC_EU, edited)

 

Title: #Influenza virus #characterisation, #Summary #Europe, September 2016 04 Nov 2016.

Subject: Seasonal Influenza Virus, genetic and antigenic characterization of recent isolate in the European Region.

Source: European Centre for Disease Prevention and Control (ECDC), full page: (LINK). Summary.

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Influenza virus characterisation, Summary Europe, September 2016 04 Nov 2016

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This document is free of charge.

 

Abstract

  • In the course of the 2015–2016 influenza season, over 139 000 influenza detections across the Region have been reported.
  • Influenza type A viruses have prevailed over type B with A(H1N1)pdm09 viruses, greatly outnumbering A(H3N2) and B/Victoria-lineage detections representing two-thirds of the type B viruses assigned to a lineage.
  • Since 1 January 2016, EU/EEA countries have shared 596 influenza-positive specimens with the Francis Crick Institute, London, for detailed characterisation.
  • Since the July report, 47 viruses have been characterised antigenically and genetically.
  • Of the 21 A(H1N1)pdm09 viruses characterised antigenically all (100%) were similar to the vaccine virus A/California/7/2009.
  • Worldwide new genetic subclusters of viruses within the 6B clade have emerged, with two being designated as subclades: 6B.1 defined by HA1 amino acid substitutions S162N and I216T and 6B.2 defined by HA1 amino acid substitutions V152T and V173I.
  • Of the 493 viruses characterised genetically for the 2015–2016 season, 29 (6%) were clade 6B, 453 (92%) were subclade 6B.1, and 11 (2%) were subclade 6B.2.
  • The two A(H3N2) test viruses characterised by haemagglutination inhibition (HI) assay were poorly recognised by reference antiserum raised against the recommended 2015–2016 vaccine virus, egg-propagated A/Switzerland/9715293/2013.
  • The test viruses were recognised somewhat better by antisera raised against egg-propagated A/Hong Kong/4801/2014, the virus recommended for use in 2016–2017 northern hemisphere and both 2016 and 2017 southern hemisphere influenza vaccines.
  • Of 127 A(H3N2) viruses characterised genetically for the 2015–2016 season, two (2%) were clade 3C.3, 90 (71%) were subclade 3C.2a, and 35 (27%) were subclade 3C.3a.
  • The 20 B/Victoria-lineage viruses were antigenically similar to tissue culture-propagated surrogates of B/Brisbane/60/2008.
  • All 184 viruses characterised genetically for the 2015–2016 season fell in genetic clade 1A, as do recently collected viruses worldwide.
  • Four B/Yamagata viruses have been characterised since the previous report. They reacted well with post-infection ferret antiserum raised against egg-propagated B/Phuket/3073/2013, the recommended vaccine virus for the northern hemisphere 2015-16 influenza season and for quadrivalent vaccines in the 2016–17 northern hemisphere and both 2016 and 2017 southern hemisphere seasons.
  • Of the 29 viruses characterised genetically for the 2015–2016 season, 28 fell in genetic clade 3 and one in clade 2.

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See more at: http://ecdc.europa.eu/en/publications/_layouts/forms/Publication_DispForm.aspx?List=4f55ad51-4aed-4d32-b960-af70113dbb90&ID=1596#sthash.VaH2GeXH.dpuf

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Keywords: ECDC; Updates; Seasonal Influenza; European Region.

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