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25 Jun 2013

Novel cyclovirus - Multistate - central nervous system infections (ECDC/CDTR, June 25 2013, edited)

[Source: European Centre for Disease Prevention and Control (ECDC), full PDF document: (LINK). Extract.]


Week 25, 16-22 June 2013



New! Novel cyclovirus - Multistate - central nervous system infections

Opening date: 19 June 2013


Epidemiological summary

A mBio article published on 18 June 2013 described the identification of a novel cyclovirus, named CyCV-VN, in cerebrospinal fluid (CSF) specimens from two Vietnamese patients with central nervous system (CNS) infections of unknown etiology. Subsequently CyCV-VN was detected in 26 of 642 (4%) acute-infection CSF specimens (collected from 1999 to 2009), including 10 of 273 (3.7%) CSF specimens from patients with CNS infections of unknown etiology and 16 of 369 (4.3%) samples from patients in whom laboratory-confirmed CNS infection with other pathogens was established. CyCV-DNA could not be detected in 122 CSF specimens collected from Vietnamese patients with noninfectious neurological disorders. CyCV-VN DNA was also detected in 8/188 (4.2%) fecal specimens from healthy children. When specimens from poultry and pigs were tested, the virus was detected in 38/65 (58%).

Another article published online on 10 June 2013 in Emerging Infectious Diseases described the detection of cyclovirus in eight (15%) of 54 serum samples and 4 (10%) of 40 CSF samples from paraplegia patients in Malawi.



ECDC assessment

This is the first time that cyclovirus is associated with human infection. However further studies are needed in order to definitively establish a causal relationship.



ECDC is preparing a Rapid Risk Assessment of these findings.