BOA1

Featured post

A Highly Pathogenic #Avian #H7N9 #Influenza Virus Isolated from A #Human Is Lethal in Some #Ferrets Infected via #Respiratory #Droplets (Cell Host Microbe, abstract)

Title : A Highly Pathogenic #Avian #H7N9 #Influenza Virus Isolated from A #Human Is Lethal in Some #Ferrets Infected via #Respiratory #Drop...

22 Oct 2017

#Yemen – #Cholera Response – Daily #Epidemiological #Update, October 21 2017 (@WHO EMRO, edited)


Title: #Yemen – #Cholera Response – Daily #Epidemiological #Update, October 21 2017.

Subject: Acute Watery Diarrhea and Cholera outbreak in Yemen, current situation.

Source: World Health Organization (WHO), Office for the Eastern Mediterranean Region, full PDF file: (LINK).

Code: [     ]

_____

Yemen – Cholera Response – Daily Epidemiological Update, October 21 2017

_____


-

Keywords: WHO; Updates; Cholera; Yemen.

------

21 Oct 2017

#Influenza and other #Respiratory #Viruses #Research #References #Library– October 21 2017 Issue


Title: #Influenza and other #Respiratory #Viruses #Research #References #Library– October 21 2017 Issue.

Subject: Human and Animal Influenza Viruses, other respiratory pathogens research, weekly references library update.

Source: AMEDEO, homepage: (LINK).

Code: [  R  ]

_____

This Issue:

___

  1. ANDREATOS N, Mylonakis E.
    • Triple therapy reduced mortality more than oseltamivir alone in patients admitted for severe influenza infection.
      • Ann Intern Med. 2017;167:JC41.
  2. GORDON NA, McGuire KL, Wallentine SK, Mohl GA, et al.
    • Divalent copper complexes as influenza A M2 inhibitors.
      • Antiviral Res. 2017;147:100-106.
  3. NIGWEKAR PV, Kumar A, Padbidri VV, Choudhury A, et al.
    • Safety of Russian-Backbone Trivalent, Live Attenuated Seasonal Influenza Vaccine in Healthy Subjects: Open-Label, Non-randomized Phase 4 Study.
      • Drug Saf. 2017 Oct 12. doi: 10.1007/s40264-017-0605.
  4. ZIVICH PN, Tatham L, Lung K, Tien J, et al.
    • Influenza vaccination status and outcomes among influenza-associated hospitalizations in Columbus, Ohio (2012-2015).
      • Epidemiol Infect. 2017 Oct 16:1-10. doi: 10.1017/S0950268817002163.
  5. HAN M, Rajput C, Hong JY, Lei J, et al.
    • The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice.
      • J Immunol. 2017;199:1308-1318.
  6. GAO S, Kang Y, Li S, Xiang B, et al.
    • Increasing genetic diversity of H5N6 avian influenza virus in china: a serious threat to persistence and dissemination in guangdong province.
      • J Infect. 2017 Oct 13. pii: S0163-4453(17)30316.
  7. SKOWRONSKI DM, Chambers C, De Serres G.
    • Selection bias in the assessment of frailty and its role in influenza vaccine effectiveness evaluation among elderly adults.
      • J Infect Dis. 2017 Oct 13. doi: 10.1093.
  8. OXMAN MN, Harbecke R, Koelle DM.
    • Clinical Usage of the Candidate Adjuvanted HZ/su Zoster Vaccine: re-vaccination of recipients of live attenuated zoster vaccine and co-administration with a seasonal influenza vaccine.
      • J Infect Dis. 2017 Sep 26. doi: 10.1093.
  9. SCHWARZ TF, Aggarwal N, Moeckesch B, Schenkenberger I, et al.
    • Immunogenicity and safety of an adjuvanted herpes zoster subunit vaccine co-administered with seasonal influenza vaccine in adults aged 50 years and older.
      • J Infect Dis. 2017 Sep 26. doi: 10.1093.
  10. BELONGIA E.
    • Beyond Antigenic Match: Moving Toward Greater Understanding of Influenza Vaccine Effectiveness.
      • J Infect Dis. 2017 Sep 27. doi: 10.1093.
  11. SKOWRONSKI DM, Chambers C, Sabaiduc S, De Serres G, et al.
    • Beyond antigenic match: possible agent-host and immuno-epidemiological influences on influenza vaccine effectiveness during the 2015-16 season in Canada.
      • J Infect Dis. 2017 Oct 4. doi: 10.1093.
  12. CHOI WS, Jeong JH, Kwon JJ, Ahn SJ, et al.
    • Screening for Neuraminidase Inhibitor Resistance Markers among Avian Influenza Viruses of the N4, N5, N6 and N8 Neuraminidase Subtypes.
      • J Virol. 2017 Oct 18. pii: JVI.01580-17. doi: 10.1128/JVI.01580.
  13. LIU H, Grantham ML, Pekosz A.
    • Mutations in the Influenza A virus M1 protein enhance virus budding to complement lethal mutations in the M2 cytoplasmic tail.
      • J Virol. 2017 Oct 18. pii: JVI.00858-17. doi: 10.1128/JVI.00858.
  14. SUTTON TC, Lamirande EW, Bock KW, Moore IN, et al.
    • In vitro neutralization is not predictive of prophylactic efficacy of broadly neutralizing monoclonal antibodies CR6261 and CR9114 against lethal H2 influenza virus challenge in mice.
      • J Virol. 2017 Oct 18. pii: JVI.01603-17. doi: 10.1128/JVI.01603.
  15. FRABUTT DA, Wang B, Riaz S, Schwartz RC, et al.
    • Innate sensing of influenza A virus hemagglutinin glycoproteins by the host endoplasmic reticulum (ER) stress pathway triggers a potent antiviral response via ER-associated protein degradation.
      • J Virol. 2017 Oct 18. pii: JVI.01690-17. doi: 10.1128/JVI.01690.
  16. BUFFIN S, Ikhelef N, Prudent J, Dubayle J, et al.
    • A latex agglutination assay to quantify the amount of hemagglutinin protein in adjuvanted low-dose influenza monovalent vaccines.
      • J Virol Methods. 2017;251:46-53.
  17. HOOS J, Peters RM, Tabatabai J, Grulich-Henn J, et al.
    • Reverse-transcription loop-mediated isothermal amplification for rapid detection of respiratory syncytial virus directly from nasopharyngeal swabs.
      • J Virol Methods. 2017;242:53-57.
  18. HU Z, Liu X, Jiao X, Liu X, et al.
    • Newcastle disease virus (NDV) recombinant expressing the hemagglutinin of H7N9 avian influenza virus protects chickens against NDV and highly pathogenic avian influenza A (H7N9) virus challenges.
      • Vaccine. 2017 Oct 14. pii: S0264-410X(17)31375.
  19. ORTIZ JR, Hombach J.
    • Announcing the publication of the WHO immunological basis for immunization series module on influenza vaccines.
      • Vaccine. 2017 Oct 14. pii: S0264-410X(17)31226.
  20. OLATUNBOSUN OD, Esterhuizen TM, Wiysonge CS.
    • A cross sectional survey to evaluate knowledge, attitudes and practices regarding seasonal influenza and influenza vaccination among diabetics in Pretoria, South Africa.
      • Vaccine. 2017 Oct 13. pii: S0264-410X(17)31370.
  21. MCELHANEY JE, Andrew MK, McNeil SA.
    • Estimating influenza vaccine effectiveness: Evolution of methods to better understand effects of confounding in older adults.
      • Vaccine. 2017;35:6269-6274.
  22. HO HJ, Chan YY, Ibrahim MAB, Wagle AA, et al.
    • A formative research-guided educational intervention to improve the knowledge and attitudes of seniors towards influenza and pneumococcal vaccinations.
      • Vaccine. 2017 Oct 11. pii: S0264-410X(17)31369.
  23. ANA-SOSA-BATIZ F, Johnston APR, Hogarth PM, Wines BD, et al.
    • Antibody-dependent phagocytosis (ADP) responses following trivalent inactivated influenza vaccination of younger and older adults.
      • Vaccine. 2017 Oct 10. pii: S0264-410X(17)31315.
  24. LION A, Richard M, Esnault E, Kut E, et al.
    • Productive replication of avian influenza viruses in chicken endothelial cells is determined by hemagglutinin cleavability and is related to innate immune escape.
      • Virology. 2017;513:29-42.
  25. BRADLEY JS, Blumer JL, Romero JR, Michaels MG, et al.
    • Intravenous Zanamivir in Hospitalized Patients With Influenza.
      • Pediatrics. 2017 Oct 19. pii: e20162727. doi: 10.1542/peds.2016-2727.

-

Keywords: Research; Abstracts; Influenza References Library.

------

#Plague #Outbreak in #Madagascar, Daily #Epidemiological #Report, October 20 2017 (Edited)


Title: Plague Outbreak in Madagascar, Daily Epidemiological Report, October 20 2017.

Subject: Plague outbreak in Madagascar, current situation.

Source: Emergency Management Office, Government of Madagascar, full page: (LINK).

Code: [     ]

_____

Plague Outbreak in Madagascar, Daily Epidemiological Report, October 20 2017

____


-

Keywords: Plague; Updates; Madagascar.

------

#Plague #Outbreak in #Madagascar, 899 cases recorded as of October 19 2017 (Inst. Pasteur, Oct. 21 ‘17)


Title: Plague Outbreak in Madagascar, 899 cases recorded as of October 19 2017.

Subject: Plague outbreak in Madagascar, current situation.

Source: Pasteur Institute of Madagascar, full page: (LINK).

Code: [     ]

____

Plague Outbreak in Madagascar, 899 cases recorded as of October 19 2017

____

-

Keywords: Plague; Updates; Madagascar.

-----

#Plague #Outbreak in #Madagascar, #fear is taking over; the island had #doctors #shortage too (Nouvel Obs., Oct. 21 ‘17)


Title: Plague Outbreak in Madagascar, fear is taking over; the island had doctors shortage too.

Subject: Plague outbreak in Madagascar; drugs and medical personnel shortages.

Source: Le Nouvel Observateur, full page: (LINK). Article in French, edited.

Code: [     ]
_____

Peste à Madagascar : "La peur s'est installée. L'île manque de médecins"
____

Chloé Pilorget-Rezzouk / Publié le 20 octobre 2017 à 12h45
En une semaine, le nombre de cas a doublé, passant de 400 à 899 malades. A Madagascar, l’épidémie de peste qui s'est déclarée fin août a déjà fait 80 morts, selon le tout dernier bilan du ministère malgache de la Santé publique. Si la Grande Ile connaît chaque année un épisode de peste, cette fois, la maladie s'est propagée hors des zones habituelles, s’étendant jusqu’aux zones urbaines de Tamatave et Tananarive – où se situe la capitale Antananarivo. Rien que dans la capitale, 40 personnes sont décédées.

(…)
-

Keywords: Plague; Madagascar.

-------

20 Oct 2017

Highly pathogenic #avian #influenza #H5N8, #Italy [two #poultry #outbreaks] (#IZSVE, Oct. 20 ‘17)


Title: Highly pathogenic #avian #influenza #H5N8, #Italy [two #poultry #outbreaks].

Subject: Avian Influenza, H5N8 subtype, poultry and wild birds epizootics in Italy.

Source: National Reference Laboratory for Avian Influenza, Padua, Italy, full page: (LINK).

Code: [     ]

_____

Highly pathogenic avian influenza (HPAI) in Italy

____

|-- Outbreaks | PDF (last update: 20/10/2017)  --|

|-- Maps | PDF (last update: 20/10/2017)  --|


Summary

  • On 17 October, the National Reference Laboratory (NRL) for Avian Influenza and Newcastle Disease confirmed as positive for Avian Influenza A virus subtype H5N8 a backyard flock in Padua province (Veneto region).
    • In the premises were present five laying hens.
    • Furthermore, six swans were resident in the property pods, which were frequented by wild mallards (Anas platyrhynchos).
    • An increase in mortality was observed on 13 October, when two swans were found dead.
    • Culling procedures of Gallinaceous birds were concluded on 18 October.
  • On the same day, NRL confirmed as positive for Avian Influenza A virus subtype H5N8 another backyard flock in Padua province (Veneto region).
    • The flock consisted of eight geese and 34 ducks.
    • Wild mallards (Anas platyrhynchos) used to frequent the pods located in the premise, and, in this way, came into contact with the flock.
    • On 13 October, an increase in mortality was observed in the flock.
    • Culling procedures have already been completed.
  • Lastly, NRL characterised as Highly Pathogenic the viruses isolated in the last outbreaks in Lombardy region.

(…)

-

Keywords: Italy; Updates; Avian Influenza; H5N8; Poultry; Wild Birds.

-------

#WHO supports #containment of rare [#Marburg] virus on #Uganda–#Kenya border (@WHO, Oct. 20 ‘17)


Title: #WHO supports #containment of rare [#Marburg] virus on #Uganda–#Kenya border.

Subject: Viral Hemorrhagic Fevers, Marburg virus infection in Uganda, current situation.

Source: World Health Organization (WHO), full page: (LINK).

Code: [     ]

_____

WHO supports containment of rare virus on Uganda-Kenya border

____

News release /  20 October 2017 / GENEVA

WHO is working to contain an outbreak of Marburg virus disease (MVD) that has appeared in eastern Uganda on the border with Kenya.

At least one person is confirmed to have died of MVD and several hundred people may have been exposed to the virus at health facilities and at traditional burial ceremonies in Kween District, a mountainous area 300 kilometres northeast of Kampala.

The first case was detected by the Ministry of Health on 17 October, a 50-year-old woman who died at a health centre of fever, bleeding, vomiting and diarrhoea on 11 October. Laboratory testing at the Uganda Virus Research Institute (UVRI) confirmed the cause of death as MVD.

The woman’s brother had also died of similar symptoms three weeks earlier and was buried at a traditional funeral. He worked as a game hunter and lived near a cave inhabited by Rousettus bats, which are natural hosts of the Marburg virus.

One suspected and one probable case are being investigated and provided with medical care. An active search for people who may have been exposed to or infected by the virus is underway.

The Ministry of Health has sent a rapid response team to the area supported by staff from the World Health Organization, the Centers for Disease Control and Prevention (CDC) and the African Field Epidemiology Network (AFNET).

WHO is providing medical supplies, guidance on safe and dignified burials, and has released USD 500 000 from its Contingency Fund for Emergencies to finance immediate response activities.

“We are working with health authorities to rapidly implement response measures,” said Ibrahima-Soce Fall, WHO Regional Emergency Director for the Africa region.

“Uganda has previously managed Ebola and Marburg outbreaks but international support is urgently required to scale up the response as the overall risk of national and regional spread of this epidemic-prone disease is high.”

Marburg virus disease is a rare disease with a high mortality rate for which there is no specific treatment.


Notes to editors

Marburg virus disease (MVD) is a severe and highly fatal disease caused by the Marburg virus from the Filoviridae family; the same family as the Ebola virus.

This virus is among the most virulent pathogens known to infect humans.

The incubation period is 2-21 days, and symptom onset is sudden and marked by fever, chills, headache, and myalgia.

Although MVD is rare, it can result in large outbreaks with high case fatality rates (CFR range from 23 to 90%). The disease is transmitted by direct contact with the blood, body fluids and tissues of infected persons or wild animals (e.g. monkeys and fruit bats).

In Uganda, the following MVD outbreaks have been recently documented:

  • 2007: 4 cases, including 2 deaths, in Ibanda District, Western Uganda
  • 2008: 2 unrelated cases in travelers returning to the Netherlands and USA, respectively after visiting caves in Western Uganda
  • 2012: 15 cases, including 4 deaths, in Ibanda and Kabale districts, Western Uganda
  • 2014: 1 case in healthcare professional from Mpigi District, Central Uganda.

___

For further information, please contact: Christian Lindmeier, WHO, Geneva, Telephone: +41 79 500 6552, Email: lindmeierch@who.int

-

Keywords: WHO; Updates; Marburg; Uganda; Kenya.

------

#Zoonotic #influenza viruses: #antigenic and #genetic characteristics and development of #CVVs for #pandemic #preparedness (@WHO, edited)


Title: #Zoonotic #influenza viruses: #antigenic and #genetic characteristics and development of #CVVs for #pandemic #preparedness.

Subject: Influenza A of Animal Origin, current situation.

Source: World Health Organization (WHO), full PDF file: (LINK).

Code: [     ]

_____

Weekly epidemiological record / 20 OCTOBER 2017, 92th YEAR No 42, 2017, 92, 625–648 http://www.who.int/wer

Zoonotic influenza viruses: antigenic and genetic characteristics and development of candidate vaccine viruses for pandemic preparedness

___


-

Keywords: WHO; Updates; Avian Influenza; Pandemic Preparedness; Vaccines.

------

#Dengue in #Pakistan: #outbreak #update (@WHO EMRO, Oct. 20 ‘17)


Title: #Dengue in #Pakistan: #outbreak #update.

Subject: Dengue fever outbreak in Pakistan, current situation.

Source: World Health Organization (WHO), Office for the Eastern Mediterranean Region, full page: (LINK).

Code: [     ]

_____

Dengue in Pakistan: outbreak update

____

19 October 2017

The provincial health department of Khyber Pakhtunkhwa Province in Pakistan has reported a cumulative total of 74 820 cases of suspected dengue fever since the outbreak was first reported on 19 July 2017, including 15 828 laboratory-confirmed cases and 54 deaths.

The district of Peshawar has reported the highest number of cases, with a current total of 68 142 suspected cases, including 14 035 confirmed cases and 50 deaths reported from local health facilities.

The Provincial Directorate of Health is coordinating efforts of the Dengue Response Unit in collaboration with WHO. This includes providing technical guidance and support for health workers in the areas of surveillance, laboratory diagnosis, case management and social mobilization. WHO has provided case management training for 30 medical officers, and held emergency training for entomologists on vector control.

To inform the community of the dangers of the outbreak, awareness sessions have been held for religious leaders, school teachers and head masters to advise the community on dengue causes and prevention. Lady health workers have been engaged to educate communities to recognize dengue symptoms and refer suspected cases to health authorities.

In addition, more than 190000 households in various areas of Peshawar have been sprayed with larvicide (space spraying) and provided health education on dengue prevention.

Dengue is a mosquito-borne viral infection that causes a severe flu-like illness, and sometimes causes a potentially lethal complication called severe dengue. The viruses are passed on to humans through the bites of an infective female Aedes mosquito, which acquires the virus while feeding on the blood of an infected person. Dengue is one of the fastest spreading viral infections in the world, and is endemic to Pakistan.

-

Keywords: WHO; Updates; Pakistan; Dengue Fever.

------

#Avian #Influenza [#H5N1, #H5N6, #H7N9] – Weekly #Update No. 607 – 20 October 2017 (@WHO WPRO, edited)


Title: #Avian #Influenza [#H5N1, #H5N6, #H7N9] – Weekly #Update No. 607 – 20 October 2017.

Subject: Avian Influenza, H5 & H7 subtypes, human cases in the Western Pacific Region of the WHO.

Source: World Health Organization (WHO), Office for the Western Pacific Region, full PDF file: (LINK).

Code: [     ]

____

Avian Influenza – Weekly Update No. 607 – 20  October 2017

____


-

Keywords: WHO; Updates; Avian Influenza; H5N6; H5N1; H7N9; Human; Asian Region.

------