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A Highly Pathogenic #Avian #H7N9 #Influenza Virus Isolated from A #Human Is Lethal in Some #Ferrets Infected via #Respiratory #Droplets (Cell Host Microbe, abstract)

Title : A Highly Pathogenic #Avian #H7N9 #Influenza Virus Isolated from A #Human Is Lethal in Some #Ferrets Infected via #Respiratory #Drop...

18 Dec 2017

#China, #Influenza [#H1N1pdm09, #H3N2, B, #H7N9]–Weekly #Report, Wk 49 ‘17, as of Dec. 18 ‘17 (CNIC, edited)


Title: #China, #Influenza [#H1N1pdm09, #H3N2, B, #H7N9]–Weekly #Report, Wk 49 ‘17, as of Dec. 18 ‘17.

Subject: Human and Avian Influenza viruses, A (H1, H3, H7) & B types, current epidemiological situation.

Source: China National Influenza Centre, full page: (LINK). Edited.

Code: [     ]

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China, Influenza Weekly Report - Week 49 2017, as of December 18 2017

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(All data are preliminary and may change as more reports are received)


Summary

  • During week 49, the levels of influenza activity in both southern and northern provinces were continued increasing.
    • Mainland China had entered the winter influenza epidemic season. The main viruses detected were B.
  • Among influenza viruses antigenically characterized by CNIC since April, 2017:
    • 1179(91.0%) influenza A(H1N1)pdm09 viruses were characterized as A/Michigan/45/2015-like;
    • 172(33%) influenza A(H3N2) viruses were characterized as A/Hong Kong/4801/2014 (H3N2)(EGG)-like,
    • 480(92%) influenza A(H3N2) viruses were characterized as A/Hong Kong/4801/2014 (H3N2)(CELL)-like;
    • 589(87.1%) influenza B/Victoria viruses were characterized as B/Brisbane/60/2008-like;
    • 266(94.3%) influenza B/Yamagata viruses were characterized as B/Phuket/3073/2013-like.
  • Among the influenza viruses tested by CNIC for antiviral resistance analysis since April, 2017:
    • all influenza A(H1N1)pdm09 and all influenza A(H3N2) viruses were resistant to adamantine;
    • All influenza H3N2 and B viruses were sensitive to neuraminidase inhibitors.
    • All but 3 influenza A(H1N1)pdm09 viruses were sensitive to neuraminidase inhibitors.


Outbreak Surveillance

  • During week 49(Dec 4th –Dec10th, 2017), there were 246 outbreaks reported nationwide, 2of them were A(H3N2), 10 of them were A(H1N1),167 of them were B , 48 of them were untyped, 15 of them were mix,4 of them were negative.


Surveillance of outpatient or emergency visits for Influenza-like Illness (ILI)

  • During week 49, the percentage of outpatient or emergency visits for ILI (ILI %) at national sentinel hospitals in southern China was 3.5%, higher than the last week and the same week of 2014-2016(3.3%, 2.2%, 2.6%, 3.3%) (Figure1).
  • During week 49, ILI% at national sentinel hospitals in northern China was 4.0%, higher than the last week and the same week of 20142016(3.7%, 3.5%, 2.5%, and 3.2%).(Figure 2)

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Figure 1. Percentage of Visits for ILI at Sentinel Hospitalsin South China (2014–2018)

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Figure 2. Percentage of Visits for ILI at Sentinel Hospitals in North China (2014–2018)

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Virologic Surveillance

  • During week 49, influenza network laboratories tested 7671 specimens, of which 1888(24.6%) were positive for influenza, influenza A and influenza B viruses were 646(34.2%) and 1242(65.8%), respectively (Table 1).
  • During week 49, the percentage of specimens that were tested positive for influenza in south China was 21.8%, which was higher than the previous week (21.0%) (Figure 3).
  • During week 49, the percentage of specimens that were tested positive for influenza in north China was 27.0%, which was higher than the previous week (20.3%). (Figure 4).


Table 1 Laboratory Detections of ILI Specimens (Week 49, 2017)

[South China - North China – Total]

  • No. of specimens tested – 3499 – 4172 – 7671
    • No. of positive specimens (%) - 763(21.8%) - 1125(27%) - 1888(24.6%)
      • Influenza A - 163(21.4%) - 483(42.9%) - 646(34.2%)
        • A(H3N2) - 42(25.8%) - 322(66.7%) - 364(56.3%)
        • A(H1N1)pdm09 - 120(73.6%) - 155(32.1%) - 275(42.6%)
        • A (subtype not determined) - 1(0.6%) - 6(1.2%) - 7(1.1%)
      • Influenza B - 600(78.6%) - 642(57.1%) - 1242(65.8%)
        • B (lineage not determined) - 27(4.5%) - 37(5.8%) - 64(5.2%)
        • Victoria - 122(20.3%) - 31(4.8%) - 153(12.3%)
        • Yamagata - 451(75.2%) - 574(89.4%) - 1025(82.5%)

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Figure 3. Influenza Positive Tests Reported by Southern Network Laboratories (Week 14, 2016–Week 49, 2017)

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Note: Analysis in this part was based on the test results of network laboratories. If it were not consistent with the results of CNIC confirmation, the results of CNIC confirmation were used.

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Figure 4. Influenza Positive Tests Reported by Northern Network Laboratories (Week 14, 2016–Week 49, 2017)

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Note: Analysis in this part was based on the result of network laboratories. If it were not consistent with the results of CNIC confirmation, the results of CNIC confirmation were used.

(…)

H7N9 case report

  • Since the notification of human infection with novel reassortant influenza A(H7N9) virus on 31 March 2013, in total 1562 laboratory-confirmed cases have been reported to WHO.
  • Among 758 cases reported in fifth wave (Since Oct 2016), 28 cases were infected with HPAI A(H7N9) virus, which have mutations in the hem agglutinin gene indicating a change to high pathogen city in poultry.
  • These 28 cases are from Taiwan (the case had travel history to Guangdong), Guangxi, Guangdong, Hunan, Shaanxi and Hebei provinces, with illness onset date before July 2017.
  • No increased transmissibility or virulence to human case was detected in the HPAI A(H7N9) virus.

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|-- china flu report 1749.pdf –|

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Keywords: China; Updates; Seasonal Influenza; Avian Influenza; H1N1pdm09; H3N2; B; H7N9.

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#Avian #Influenza [#H5N1, #H5N6, #H7N9]–Weekly #Update No. 615, December 15 2017 (@WHO WPRO, edited)


Title: #Avian #Influenza [#H5N1, #H5N6, #H7N9]–Weekly #Update No. 615, December 15 2017.

Subject: Avian Influenza, H5 & H7 subtypes, global poultry panzootic and human cases in the Asian Region.

Source: World Health Organization (WHO), full PDF file: (LINK).

Code: [     ]

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Avian Influenza - Weekly Update No. 615, December 15 2017

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Keywords: WHO; Updates; Asian Region; Avian Influenza; Human; H5N1; H5N6; H7N9.

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17 Dec 2017

#Influenza and other #Respiratory #Viruses #Research #References #Library– December 17 2017 Issue


Title: #Influenza and other #Respiratory #Viruses #Research #References #Library– December 17 2017 Issue.

Subject: Human and Animal Influenza Viruses, other respiratory pathogens research, weekly references library update.

Source: AMEDEO, homepage: (LINK).

Code: [  R  ]

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This Issue:

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  1. PETROVA NV, Emelyanova AG, Gorbunov EA, Edwards MR, et al.
    • Efficacy of novel antibody-based drugs against rhinovirus infection: In vitro and in vivo results.
      • Antiviral Res. 2017;142:185-192.
  2. TELCIAN AG, Zdrenghea MT, Edwards MR, Laza-Stanca V, et al.
    • Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro.
      • Antiviral Res. 2017;137:93-101.
  3. WHITE MC, Lowen AC.
    • Implications of segment mismatch for influenza A virus evolution.
      • J Gen Virol. 2017 Dec 15. doi: 10.1099/jgv.0.000989.
  4. AMODIO D, Cotugno N, Macchiarulo G, Rocca S, et al.
    • Quantitative Multiplexed Imaging Analysis Reveals a Strong Association between Immunogen-Specific B Cell Responses and Tonsillar Germinal Center Immune Dynamics in Children after Influenza Vaccination.
      • J Immunol. 2017 Dec 13. pii: jimmunol.1701312. doi: 10.4049/jimmunol.1701312.
  5. MADARAS-KELLY K, Remington R, Hruza H, Xu D, et al.
    • The Comparative Effectiveness of High-Dose Versus Standard-Dose Influenza Vaccines in Preventing Post-Influenza Deaths.
      • J Infect Dis. 2017 Dec 9. pii: 4718125. doi: 10.1093.
  6. LU X, Schneider E, Jain S, Bramley AM, et al.
    • Rhinovirus Viremia in Patients Hospitalized With Community-Acquired Pneumonia.
      • J Infect Dis. 2017;216:1104-1111.
  7. MARIANI TJ, Qiu X, Chu C, Wang L, et al.
    • Association of Dynamic Changes in the CD4 T-Cell Transcriptome With Disease Severity During Primary Respiratory Syncytial Virus Infection in Young Infants.
      • J Infect Dis. 2017;216:1027-1037.
  8. VER LS, Marcos-Villar L, Landeras-Bueno S, Nieto A, et al.
    • Correction for Ver et al., "The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication".
  9. CHAUCHE C, Nogales A, Zhu H, Goldfarb D, et al.
    • Mammalian adaptation of an avian influenza A virus involves stepwise changes in NS1.
      • J Virol. 2017 Dec 13. pii: JVI.01875-17. doi: 10.1128/JVI.01875.
  10. TURKINGTON HL, Juozapaitis M, Tsolakos N, Corrales-Aguilar E, et al.
    • Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins.
      • J Virol. 2017 Dec 13. pii: JVI.02097-17. doi: 10.1128/JVI.02097.
  11. RABENSTEINER A, Buja A, Regele D, Fischer M, et al.
    • Healthcare worker's attitude to seasonal influenza vaccination in the South Tyrolean province of Italy: barriers and facilitators.
      • Vaccine. 2017 Dec 11. pii: S0264-410X(17)31734.
  12. ORTIZ JR, Hickling J, Jones R, Donabedian A, et al.
    • Report on eighth WHO meeting on development of influenza vaccines that induce broadly protective and long-lasting immune responses: Chicago, USA, 23-24 August 2016.
      • Vaccine. 2017 Dec 5. pii: S0264-410X(17)31645.
  13. CISZEWSKI A.
    • Cardioprotective effect of influenza and pneumococcal vaccination in patients with cardiovascular diseases.
      • Vaccine. 2018;36:202-206.
  14. KURZ X, Bauchau V, Mahy P, Glismann S, et al.
    • The ADVANCE Code of Conduct for collaborative vaccine studies.
      • Vaccine. 2017 Mar 9. pii: S0264-410X(17)30242.
  15. GERSHWIN LJ, Behrens NE, McEligot HA, Carvallo-Chaigneau FR, et al.
    • A recombinant subunit vaccine for bovine RSV and Histophilus somni protects calves against dual pathogen challenge.
      • Vaccine. 2017 Mar 5. pii: S0264-410X(17)30125.
  16. MADAN A, Ferguson M, Sheldon E, Segall N, et al.
    • Immunogenicity and safety of an AS03-adjuvanted H7N1 vaccine in healthy adults: A phase I/II, observer-blind, randomized, controlled trial.
      • Vaccine. 2017 Feb 7. pii: S0264-410X(17)30119.
  17. FUENTES S, Arenas D, Moore MM, Golding H, et al.
    • Development of bioluminescence imaging of respiratory syncytial virus (RSV) in virus-infected live mice and its use for evaluation of therapeutics and vaccines.
      • Vaccine. 2016 Dec 15. pii: S0264-410X(16)31105.
  18. PAN-NGUM W, Kinyanjui T, Kiti M, Taylor S, et al.
    • Predicting the relative impacts of maternal and neonatal respiratory syncytial virus (RSV) vaccine target product profiles: A consensus modelling approach.
      • Vaccine. 2016 Nov 28. pii: S0264-410X(16)31023.
  19. HERRERA-RODRIGUEZ J, Meijerhof T, Niesters HG, Stjernholm G, et al.
    • A novel peptide-based vaccine candidate with protective efficacy against influenza A in a mouse model.
      • Virology. 2017;515:21-28.

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Keywords: Research; Abstracts; Influenza References Library.

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#China, #Hunan: #Avian #Influenza #H7N9 virus detected in #poultry market samples, no #human cases so far (Dec. 17 ‘17)


Title: #China, #Hunan: #Avian #Influenza #H7N9 virus detected in #poultry market samples, no #human cases so far.

Subject: Avian Influenza, H7N9 subtype, poultry epizootic and human cases in China.

Source: Local Media, full page: (LINK). Article in Chinese, edited.

Code: [     ][     ]

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Live Poultry Market Samples tested positive for H7N9 avian flu virus

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According to the provincial and municipal plan "2017 unidentified pneumonia and human infection prevention and control of bird flu implementation plan," on December 15, 2017 Changde City CDC sent to counties around the city a task force to collect live poultry market environment samples.

A total of 32 specimens were collected on the same day. Among them, 4 specimens were positive for H7 influenza virus nucleic acid, including 1 in Wuling District, 1 in Hanshou County, 1 in Anxiang County and 1 in West Lake Management Area.

The test results out CDC City Center immediately positive results back to the relevant CDC and the city animal epidemic control center, and instruct the relevant CDC in accordance with national, provincial and municipal documents, specifications, program requirements, norms Do a good job of reporting, investigating and handling monitoring results.

As of December 17, 2017, no human cases of H7N9 bird flu have been reported in our city.

According to the monitoring results, it was proved that the live fowls sold in some live poultry markets in our city were infected with the H7N9 bird flu virus.

According to the prevalence of human infection with H7N9 bird flu, CDC experts carefully analyzed and judged that the possibility of a large-scale human bird flu outbreak is unlikely, but there is still a risk of sporadic cases.

City CDC will continue to strengthen the joint prevention and control with the relevant departments of agriculture, industry and commerce and other departments to strengthen information exchange and sharing, good live poultry sales market H7N9 bird flu virus contamination and human epidemic monitoring, supervision and guidance detected H7 Influenza virus nucleic acid-positive municipal CDC standard monitoring report of the results of the investigation and disposal.

(…)

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Keywords: China; Hunan; H7N9; Avian Influenza; Poultry.

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16 Dec 2017

[Central and South #America Regions] #Epidemiological #Update–#Diphtheria - 15 December 2017 (via ReliefWeb, edited)


Title: [Central and South #America Regions] #Epidemiological #Update–#Diphtheria - 15 December 2017.

Subject: Diphtheria cases in the Central, Caribbean and South America Regions.

Source: ReliefWeb, full page: (LINK).

Code: [     ]

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Epidemiological Update - Diphtheria - 15 December 2017

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Report from World Health Organization, Pan American Health Organization / Published on 15 Dec 2017 — View Original

|--  Download PDF (125.87 KB) –|


Diphtheria in the Americas - Summary of the situation

    • Between epidemiological week (EW) 1 and EW 49 of 2017, Brazil, the Dominican Republic, Haiti, and the Bolivarian Republic of Venezuela reported confirmed diphtheria cases.
    • The following is a summary for each country.
  • In Brazil, up to EW 49 of 2017, 14 states reported a total of 42 suspected diphtheria cases, including 41 which were confirmed in Acre, Minas Gerais, Roraima, and São Paulo states; 1 by laboratory testing and 3 by clinical criteria.
    • Out of the four cases, 2 were not vaccinated (including the laboratory confirmed case) and 2 had an uncompleted vaccination schedule.
    • The confirmed cases range between 4 and 51 years of age, and include 3 males and 1 female.
    • There was 1 fatal confirmed case; this is the previously reported laboratory confirmed case imported from Venezuela.
    • There were no secondary cases related to this case nor have there been additional imported cases reported in Brazil.
  • In the Dominican Republic, there were 3 confirmed diphtheria cases reported in the last diphtheria epidemiological update of 15 November 2017; however, the Ministry of Public Health and Social Assistance has since reported that only one was confirmed for diphtheria as the other two cases were discarded by clinical criteria (1) and by laboratory (1).
    • No fatal case was reported.
  • In Haiti, the outbreak began at the end of 2014 and has continued to occur with a total of 348 probable diphtheria cases reported up to EW 48 of 2017, including 46 deaths.
    • An increase in cases is observed in the last trimester of 2017 compared to the preceding trimester (Figure 1).
    • Between EW 1 and EW 48 of 2017, 152 probable cases were reported, with a case fatality rate of 10%.
    • Of these cases, 59% are female and 76% are infants under the age of ten.
    • The vaccination history of the probable cases is the following: 11% were vaccinated and 89% did not know or did not have information on their vaccination status.
    • Most of the probable cases (71%) were reported in the departments of Artibonite and Ouest (38% and 33%, respectively); this is similar to what was observed in 2016 with 70% of the cases reported in the same two departments.
    • Of the 152 probable cases reported in 2017, samples were taken from 141 cases, of which 64 (45%) were laboratory confirmed, 52 were discarded, and 25 remain under investigation.
    • Of the confirmed cases, 81% (52) are from the departments of Artibonite and Ouest.
    • Epidemiological surveillance is being intensified to detect the population at risk and to implement public health measures, including a vaccination campaign expected to take place in 2018.
  • In Venezuela, between EW 28 of 2016 and EW 48 of 2017, a diphtheria outbreak was reported, starting from Sifontes municipality, Bolívar state and spreading to 21 other states in the country.
    • A total of 933 probable diphtheria cases were reported, 324 of which occurred in 2016.
    • From EW 1 to EW 48 of 2017, 609 probable cases of diphtheria were reported (21% case fatality rate), of which 227 were laboratory confirmed (by isolation or polymerase chain reaction).
    • Among the confirmed cases (198 cases), 14% have a history of vaccination and 56% are female.
    • The most affected individuals are those aged 11 or older, which accounted for 72% of the confirmed cases.
    • The Venezuela Ministry of People's Power for Health is intensifying vaccination activities in municipalities with cases and a vaccination campaign is planned to begin in early 2018.
    • All federal entities have been alerted and epidemiological surveillance, active case search, follow-up of contacts, diagnostic capacity are being strengthened.

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Keywords: WHO; Updates; Diphtheria; Venezuela; Haiti; Dominican Republic; Brazil.

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15 Dec 2017

Highly pathogenic #avian #influenza #H5N8, #SouthAfrica [a #poultry #outbreak] (#OIE, Dec. 15 ‘17)


Title: Highly pathogenic #avian #influenza #H5N8, #SouthAfrica [a #poultry #outbreak].

Subject: Avian Influenza, H5N8 subtype, poultry epizootics in South Africa.

Source: OIE, full page: (LINK).

Code: [     ]

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Highly pathogenic avian influenza H5N8, South Africa

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Information received on 15/12/2017 from Dr Bothle Michael Modisane, Chief Director , Department of Agriculture, Forestry and Fisheries, Animal Production and Health, PRETORIA, South Africa

  • Summary
    • Report type    Follow-up report No. 21
    • Date of start of the event    19/06/2017
    • Date of confirmation of the event    22/06/2017
    • Report date    15/12/2017
    • Date submitted to OIE    15/12/2017
    • Reason for notification    New strain of a listed disease in the country
    • Causal agent    Highly pathogenic avian influenza virus
    • Serotype    H5N8
    • Nature of diagnosis    Clinical, Laboratory (advanced)
    • This event pertains to    a defined zone within the country
  • Summary of outbreaks   
    • Total outbreaks: 1
      • Total animals affected: Species    - Susceptible    - Cases    - Deaths    - Killed and disposed of – Slaughtered
        • Birds    - 1260    - 2    - 0    - 0    - 0
      • Outbreak statistics: Species    - Apparent morbidity rate    - Apparent mortality rate    - Apparent case fatality rate    - Proportion susceptible animals lost*
        • Birds    - 0.16%    - 0.00%    - 0.00%    - 0.00%
          • *Removed from the susceptible population through death, destruction and/or slaughter
  • Epidemiology
    • Source of the outbreak(s) or origin of infection   
      • Unknown or inconclusive
  • Epidemiological comments   
    • Coordinates modified to protect confidentiality as required by South African Legislation.

(...)

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Keywords: OIE; Updates; Avian Influenza; H5N8 ; Poultry; South Africa.

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Weekly #US #Influenza #Surveillance #Report - 2017-18 Season, Wk 49 ending Dec. 9 ‘17 (@CDCgov, summary)


Title: Weekly #US #Influenza #Surveillance #Report - 2017-18 Season, Wk 49 ending Dec. 9 ‘17.

Subject:  Human Influenza Viruses, A & B types, current epidemiological situation.

Source: US Centers for Disease Control and Prevention (CDC), FluView, full page: (LINK). Summary, edited.

Code: [     ]

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Weekly U.S. Influenza Surveillance Report - 2017-2018 Influenza Season Week 49 ending December 9, 2017

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Language: [ English (US)Español ]

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All data are preliminary and may change as more reports are received.


Synopsis

    • During week 49 (December 3-9, 2017), influenza activity increased in the United States.
  • Viral Surveillance:
    • The most frequently identified influenza virus type reported by public health laboratories during week 49 was influenza A.
    • The percentage of respiratory specimens testing positive for influenza in clinical laboratories increased.
  • Novel Influenza A Virus:
    • One human infection with a novel influenza A virus was reported.
  • Pneumonia and Influenza Mortality:
    • The proportion of deaths attributed to pneumonia and influenza (P&I) was below the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths:
    • One influenza-associated pediatric death was reported.
  • Influenza-associated Hospitalizations:
    • A cumulative rate of 4.3 laboratory-confirmed influenza-associated hospitalizations per 100,000 population was reported.
  • Outpatient Illness Surveillance:
    • The proportion of outpatient visits for influenza-like illness (ILI) was 2.7%, which is above the national baseline of 2.2%.
    • Seven of the 10 regions reported ILI at or above region-specific baseline levels.
    • Four states experienced high ILI activity; five states experienced moderate ILI activity; New York City, Puerto Rico, and 16 states experienced low ILI activity; 25 states experienced minimal ILI activity; and the District of Columbia had insufficient data.
  • Geographic Spread of Influenza:
    • The geographic spread of influenza in 12 states was reported as widespread; Puerto Rico and 26 states reported regional activity; 10 states reported local activity; the District of Columbia, the U.S. Virgin Islands and two states reported sporadic activity; and Guam did not report.

(…)

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Keywords: US CDC; USA; Updates; Seasonal Influenza.

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#USA reported one additional case of #human #infection with #influenza #H3N2v virus (@CDCgov, Dec. 15 ‘17)


Title: #USA reported one additional case of #human #infection with #influenza #H3N2v virus.

Subject: Influenza A of Swine Origin, H3N2v subtype, human case.

Source: US Centers for Disease Control and Prevention (CDC), full page: (LINK). Extract, edited.]

Code: [     ]

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(…)

Novel Influenza A Virus

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One human infection with a novel influenza A virus was reported by Iowa during week 49. This person was infected with an influenza A(H3N2) variant [A(H3N2)v] virus and reported direct contact with swine during the week preceding illness onset.

The patient was an adult < 50 years of age, was not hospitalized, and has fully recovered from their illness.

No human-to-human transmission has been identified.

A total of 67 variant virus infections have been reported to CDC during 2017.

Sixty-two of these have been A(H3N2)v viruses (Delaware [1], Iowa [1], Maryland [39], Michigan [2], Nebraska [1], North Dakota [1], Ohio [15], Pennsylvania [1], and Texas [1]), one was an influenza A(H1N1) variant [A(H1N1)v] (Iowa [1]) virus, and four were influenza A(H1N2) variant [A(H1N2)v] viruses (Colorado [1] and Ohio [3]).

Six of these 67 infections resulted in hospitalization; all patients have recovered.

Early identification and investigation of human infections with novel influenza A viruses are critical so that the risk of infection can be more fully understood and appropriate public health measures can be taken.

Additional information on influenza in swine, variant influenza infection in humans, and strategies to interact safely with swine can be found at http://www.cdc.gov/flu/swineflu/index.htm. .

(…)

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Keywords: US CDC; USA; Updates; Swine Influenza; H3N2v; Human.

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#Review of #global #influenza #activity, October 2016– October 2017 (@WHO, Dec. 15 ‘17)


Title: #Review of #global #influenza #activity, October 2016– October 2017.

Subject: Human Influenza Viruses, A & B types, global activity report.

Source: World Health Organization (WHO), Weekly Epidemiological Record (WER), full PDF file: (LINK).

Code: [     ]

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Keywords: WHO; Worldwide; Updates; Influenza A; Influenza B; H1N1pdm09; H3N2.

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Highly pathogenic #avian #influenza #H5N6, #Netherlands [infected #wildbirds] (#OIE, Dec. 15 ‘17)


Title: Highly pathogenic #avian #influenza #H5N6, #Netherlands [infected #wildbirds].

Subject: Avian Influenza, H5N6 subtype, wild birds epizootics in Netherlands.

Source: OIE, full page: (LINK).

Code: [     ]

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Highly pathogenic influenza A viruses (infection with) (non-poultry including wild birds) H5N6, Netherlands

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Information received on 15/12/2017 from Dr Christianne Bruschke, Chief Veterinary Officer , Ministry of Economic Affairs, Ministry of Economic Affairs, The Hague, Netherlands

  • Summary
    • Report type    Immediate notification
    • Date of start of the event    09/12/2017
    • Date of confirmation of the event    13/12/2017
    • Report date    15/12/2017
    • Date submitted to OIE    15/12/2017
    • Reason for notification    Recurrence of a listed disease
    • Date of previous occurrence    16/05/2017
    • Manifestation of disease    Clinical disease
    • Causal agent    Highly pathogenic influenza A virus
    • Serotype    H5N6
    • Nature of diagnosis    Clinical, Laboratory (advanced)
    • This event pertains to    a defined zone within the country
  • New outbreaks (2)
    • Outbreak 1 (HPAI WB H5N6 2017-01)    - Elburg, GELDERLAND
      • Date of start of the outbreak    09/12/2017
      • Outbreak status    Continuing (or date resolved not provided)
      • Epidemiological unit    Village
      • Affected animals: Species    - Susceptible    - Cases    - Deaths    - Killed and disposed of – Slaughtered
        • Mute Swan:Cygnus olor(Anatidae)  - … – 1    - 1    - 0    - 0
    • Outbreak 2 (HPAI WB H5N6 2017-02)    - Hulshorst, GELDERLAND
      • Date of start of the outbreak    09/12/2017
      • Outbreak status    Continuing (or date resolved not provided)
      • Epidemiological unit    Village
      • Affected animals: Species    - Susceptible    - Cases    - Deaths    - Killed and disposed of – Slaughtered
        • Mute Swan:Cygnus olor(Anatidae) – … – 6    - 6    - 0    - 0
  • Summary of outbreaks   
    • Total outbreaks: 2
      • Total animals affected: Species    - Susceptible    - Cases    - Deaths    - Killed and disposed of – Slaughtered
        • Mute Swan:Cygnus olor(Anatidae)  - … – 7    - 7    - 0    - 0
      • Outbreak statistics: Species    - Apparent morbidity rate    - Apparent mortality rate    - Apparent case fatality rate    - Proportion susceptible animals lost*
        • Mute Swan:Cygnus olor(Anatidae)    - **    - **    - 100.00%    - **
          • *Removed from the susceptible population through death, destruction and/or slaughter
          • **Not calculated because of missing information
  • Epidemiology
    • Source of the outbreak(s) or origin of infection   
      • Unknown or inconclusive
  • Epidemiological comments   
    • H5N6 was confirmed in 7 Cygnus olor found in wetland areas near Elburg and Hulshorst.
    • Subtype H5N6 is a reassortment linked to H5N8, it is not the Asian zoonotic H5N6.
  • Control measures
    • Measures applied   
      • Vaccination permitted (if a vaccine exists)
      • No treatment of affected animals
    • Measures to be applied   
      • No other measures
  • Diagnostic test results
    • Laboratory name and type    - Species    - Test    - Test date    - Result
      • Wageningen Bioveterinary Research, Lelystad (National laboratory)    - Mute Swan    - polymerase chain reaction (PCR)    - 13/12/2017    - Positive
  • Future Reporting
    • The event is continuing. Weekly follow-up reports will be submitted.

(...)

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Keywords: OIE; Updates; Avian Influenza; H5N6 ; Wild Birds; Netherlands.

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