BOA1

Featured post

#Avian #Influenza #H7N9 in #China: Preventing the Next #SARS (@WHO, Apr. 2 ‘17)

  Title : #Avian #Influenza #H7N9 in #China: Preventing the Next #SARS. Subject : Avian Influenza, H7N9 subtype (Asian Lineage), poultry e...

8 May 2017

#Zika Virus and related complications – #Journals #Archives, recent added articles (May 8 2017)

 

Title: #Zika Virus and related complications – #Journals #Archives, recent added articles (May 8 2017).

Subject: Zika Virus Infection and related complications research, deep web scanning for Journals’ Archives.

Source: WorldWideScience.org, full page: (LINK).

Code: [  R  ]

_____

See more at –> WorldWideScience.org  - Alerts for 2017-05-08

____

Newly scanned articles:

___

      • Monel, Blandine; Compton, Alex A; Bruel, Timothée; Amraoui, Sonia; Burlaud-Gaillard, Julien; Roy, Nicolas; Guivel-Benhassine, Florence; Porrot, Françoise; Génin, Pierre; Meertens, Laurent; Sinigaglia, Laura; Jouvenet, Nolwenn; Weil, Robert; Casartelli, Nicoletta; Demangel, Caroline; Simon-Lorière, Etienne; Moris, Arnaud; Roingeard, Philippe; Amara, Ali; Schwartz, Olivier
      • 2017-05-04  PubMed
      • DOI: 10.15252/embj.201695597
      • Keywords: IFITM, ZIKA virus, cell death, cytopathic effect, paraptosis
        • The cytopathic effects of Zika virus (ZIKV) are poorly characterized. Innate immunity controls ZIKV infection and disease in most infected patients through mechanisms that remain to be understood. Here, we studied the morphological cellular changes induced by ZIKV and addressed the role of interferon-induced transmembrane proteins (IFITM), a family of broad-spectrum antiviral factors, during viral replication. We report that ZIKV induces massive vacuolization followed by "implosive" cell death in human epithelial cells, primary skin fibroblasts and astrocytes, a phenomenon which is exacerbated when IFITM3 levels are low. It is reminiscent of paraptosis, a caspase-independent, non-apoptotic form of cell death associated with the formation of large cytoplasmic vacuoles. We further show that ZIKV-induced vacuoles are derived from the endoplasmic reticulum (ER) and dependent on the PI3K/Akt signaling axis. Inhibiting the Sec61 ER translocon in ZIKV-infected cells blocked vacuole formation and viral production. Our results provide mechanistic insight behind the ZIKV-induced cytopathic effect and indicate that IFITM3, by acting as a gatekeeper for incoming virus, restricts virus takeover of the ER and subsequent cell death. © 2017 Institut Pasteur.
      • Willis, Elinor; Hensley, Scott E
      • 2017-05-02  PubMed
      • DOI: 10.1016/j.virol.2017.04.031  Volume: 508  Pages: 1-6
      • Keywords: Antibody, Antibody mediated enhancement, Flavivirus, Zika virus
        • Zika viruses (ZIKVs) are circulating in parts of the world endemic for other flavivirus infections. Some cross-reactive antibodies (Abs) elicited by prior flavivirus exposures can bind to ZIKV and enhance infection of Fc receptor-bearing cells. Here, we measured ZIKV binding of 54 murine monoclonal Abs (mAbs) elicited by exposure with Dengue virus and West Nile virus antigens. We found that 8 of 54 mAbs recognized the envelope protein of ZIKV in conventional binding assays. These 8 cross-reactive mAbs have different specificities; most recognize the DI/II region of the envelope protein but one mAb recognized the DIII lateral ridge of the envelope protein. Interestingly, only 3 of these cross-reactive mAbs were able to enhance ZIKV infection in vitro, and enhancing potential was not strictly correlated with relative binding ability. These data suggest that the ability of flavivirus Abs to enhance ZIKV is dependent on multiple factors. Copyright © 2017 Elsevier Inc. All rights reserved.
      • Smith, Orla M
      • 2017-05-05  PubMed
      • DOI: 10.1126/science.356.6337.497-g  Volume: 356  Issue: 6337  Pages: 497-498
      • Robbiani, Davide F; Bozzacco, Leonia; Keeffe, Jennifer R; Khouri, Ricardo; Olsen, Priscilla C; Gazumyan, Anna; Schaefer-Babajew, Dennis; Avila-Rios, Santiago; Nogueira, Lilian; Patel, Roshni; Azzopardi, Stephanie A; Uhl, Lion F K; Saeed, Mohsan; Sevilla-Reyes, Edgar E; Agudelo, Marianna; Yao, Kai-Hui; Golijanin, Jovana; Gristick, Harry B; Lee, Yu E; Hurley, Arlene; Caskey, Marina; Pai, Joy; Oliveira, Thiago; Wunder, Elsio A; Sacramento, Gielson; Nery, Nivison; Orge, Cibele; Costa, Federico; Reis, Mitermayer G; Thomas, Neena M; Eisenreich, Thomas; Weinberger, Daniel M; de Almeida, Antonio R P; West, Anthony P; Rice, Charles M; Bjorkman, Pamela J; Reyes-Teran, Gustavo; Ko, Albert I; MacDonald, Margaret R; Nussenzweig, Michel C
      • 2017-05-04  PubMed
      • DOI: 10.1016/j.cell.2017.04.024  Volume: 169  Issue: 4  Pages: 597-609.e11
      • Keywords: Zika virus, antibodies, dengue virus, flavivirus, structure, vaccine
        • Antibodies to Zika virus (ZIKV) can be protective. To examine the antibody response in individuals who develop high titers of anti-ZIKV antibodies, we screened cohorts in Brazil and Mexico for ZIKV envelope domain III (ZEDIII) binding and neutralization. We find that serologic reactivity to dengue 1 virus (DENV1) EDIII before ZIKV exposure is associated with increased ZIKV neutralizing titers after exposure. Antibody cloning shows that donors with high ZIKV neutralizing antibody titers have expanded clones of memory B cells that express the same immunoglobulin VH3-23/VK1-5 genes. These recurring antibodies cross-react with DENV1, but not other flaviviruses, neutralize both DENV1 and ZIKV, and protect mice against ZIKV challenge. Structural analyses reveal the mechanism of recognition of the ZEDIII lateral ridge by VH3-23/VK1-5 antibodies. Serologic testing shows that antibodies to this region correlate with serum neutralizing activity to ZIKV. Thus, high neutralizing responses to ZIKV are associated with pre-existing reactivity to DENV1 in humans. Copyright © 2017 Elsevier Inc. All rights reserved.

___

Copyright © 2017 Deep Web Technologies, Inc. All Rights Reserved

-

Keywords: Research; Abstracts; WWS; Zika Virus.

------