Title: #Taiwan, #H7N9 #influenza virus from imported #human case highly similar to #China isolates, denotes an #HPAI trait.
Subject: Avian Influenza, H7N9 subtype, imported human case in Taiwan; gene sequence of viral isolates showed multiple amino-acids residues at the Hemagglutinin cleavage site, typical of highly pathogenic avian influenza viruses in birds.
Source: Taipei Center for Disease Control and Prevention (CDC), full page: (LINK). Article in Chinese, edited.
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CDC continues to monitor the international H7N9 flu epidemic; travelers should follow protection measures
Center for Disease Control and Prevention on Feb 13 has successfully isolated the H7N9 influenza virus from samples collected from the first human imported case of the year.
On Feb. 15, full genomic sequence of isolates has been performed and shared with GISAID database.
The results showed that the H7N9 influenza virus had a high homology with Chinese isolates both in the hemagglutinin (HA) and the Neuraminidase (NA) genes.
Other internal proteins sequences - compared with current circulating virus – showed slightly differences, denoting a possible new genotype, with a highly pathogenic trait in birds, but with no known mutations related to increased pathogenicity or transmissibility both in human and birds.
The Agency has said that the presence of three basic amino acids residues in the HA protein cleavage site may increase its pathogenicity in poultry.
In addition, further gene sequence analysis showed that the NA protein of the virus has a mutation conferring antiviral resistance to oseltamivir, possibly linked to treatment.
CDC on Feb. 15 notified the result of antiviral sensitivity analysis to health care providers that are treating the imported case, currently still hospitalized in serious condition.
CDC will keep abreast of trends in the international human and bird H7N9 virus epidemic strains, strengthen immediate epidemic surveillance and virus surveillance , and today announced the update of the new clinical guidelines for influenza A influenza A to ensure that people health.
The patient’s close contacts are given appropriate health education and health advice. The total number of contacts is 141, all ended surveillance period on Feb. 13.
So far this season, China reported 426 human cases of H7N9 influenza, the most affected provinces:
- Jiangsu Province, 124 cases
- Zhejiang Province 75 cases,
- Guangdong Province, 47 cases
- Anhui 45 cases.
Many cases had poultry, or live poultry market exposure history, an age of 50 years old or more.
Worldwide since 2013 so far this year a total of 1,224 cases have been reported according the WHO, with 359 deaths.
Keywords: Taiwan; Updates; China; H7N9; Avian Influenza, Human.