9 Jan 2014

A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November to December 2013 (Euro Surveill., abstract, edited)

[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]

Eurosurveillance, Volume 19, Issue 1, 09 January 2014

Rapid communications

A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November to December 2013

E Takashita1, K Ejima1, R Itoh1, M Miura1, A Ohnishi2, H Nishimura3, T Odagiri1, M Tashiro 1

1Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan – 2 Sapporo City Institute of Public Health, Hokkaido, Japan  - 3 Virus Research Center, Sendai Medical Center, Miyagi, Japan

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Citation style for this article: Takashita E, Ejima K, Itoh R, Miura M, Ohnishi A, Nishimura H, Odagiri T, Tashiro M. A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November to December 2013. Euro Surveill. 2014;19(1):pii=20666. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20666
Date of submission: 30 December 2013

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Six influenza A(H1N1)pdm09 viruses were detected in Sapporo, Japan, between November and December 2013. All six viruses possessed an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir. No epidemiological link among the six cases could be identified; none of them had received neuraminidase inhibitors before specimen collection. The haemagglutinin and neuraminidase genes of the six viruses were closely related to one another, suggesting clonal spread of a single resistant virus.

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