17 Aug 2013

Effectiveness of non-adjuvanted monovalent A(H1N1)pdm09 vaccines for preventing RT-PCR-confirmed pandemic influenza hospitalizations: Case-control study of children and adults at ten U.S. Influenza Surveillance Network sites (Clin Infect Dis., abstract, edited)

[Source: Clinical Infectious Diseases Journal, full page: (LINK). Abstract, edited.]

Effectiveness of non-adjuvanted monovalent A(H1N1)pdm09 vaccines for preventing RT-PCR-confirmed pandemic influenza hospitalizations: Case-control study of children and adults at ten U.S. Influenza Surveillance Network sites

Mark Thompson 1,*, Leslie Z. Sokolow 1,2,**, Olivia Almendares 3,4, Kyle Openo 3,4, Monica M. Farley 3,5, James Meek 6, Julie Ray 6, Pamala Daily Kirley 7, Arthur Reingold 8, Deborah Aragon 9, Emily Hancock 10, Joan Baumbach 10, William Schaffner 11,12, Ruth Lynfield 15, Pat Ryan 14, Maya Monroe 14, Po-Yung Cheng 1,2, Alicia Fry 1, and David K. Shay 1

Author Affiliations: 1Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia 2Battelle Memorial Institute, Atlanta, Georgia 3Atlanta VA Medical Center, Atlanta, Georgia 4Atlanta Research and Education Foundation, Atlanta, Georgia 5Emory University School of Medicine 6Connecticut Emerging Infections Program, New Haven, Connecticut 7California Emerging Infections Program, Oakland, California 8Department of Epidemiology, School of Public Health, University of California, Berkeley, California 9Colorado Department of Public Health and Environment, Denver, Colorado 10New Mexico Emerging Infections Program, Santa Fe, New Mexico 11Tennessee Department of Health, Nashville, Tennessee 12Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 14Maryland Department of Health and Mental Hygiene, Baltimore, Maryland 15Minnesota Department of Health, St. Paul, Minnesota

*Primary corresponding author: Influenza Division, MS-A32, 1600 Clifton Rd., Atlanta GA 30333; telephone: (404) 583-5737; email: isq8@cdc.gov.

** Secondary corresponding author: Same address; telephone: (404) 639-1720; email: bkk5@cdc.gov.

 

Abstract

During 2009-2010, we examined 217 cases hospitalized with laboratory-confirmed pandemic influenza in nine FluSurv-NET sites and 413 age- and community-matched controls and found a single dose of monovalent non-adjuvanted influenza A(H1N1)pdm09 vaccine was 50% (95% CI=13%–71%) effective in preventing hospitalization associated with A(H1N1)pdm09 virus infection.

Received May 28, 2013. Accepted August 11, 2013.

Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2013.

Clin Infect Dis. (2013) doi: 10.1093/cid/cit551 First published online: August 15, 2013

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