3 Jul 2013

China National Influenza Center Director: H7N9 will return this fall or during the winter (Ifeng, July 3 2013, edited)

[Source: Ifeng, full page in Chinese: (LINK). Automatic translation.]

China National Influenza Center Director: H7N9 will return this fall or during the winter

At 02:29 on July 4, 2013 Source: Beijing News

 

Dialogue People: Shu Yuelong China CDC deputy director of the virus, the National Influenza Center, World Health Organization Influenza Collaborating Centre for Reference and Research Director. The world's first novel H7N9 isolates of avian influenza virus people.

Original title: Shu Yuelong: "H7N9 this fall and winter will be back."

■ dialogue motivation

It is a kind of virus, both seasonal influenza virus receptor binding, but also easy with the avian influenza virus receptor binding; also in humans off "cytokine storm", causing infections in critical condition. Today, the new issue of "Nature" magazine published scientific research team, Professor Shu Yuelong article, said a large number of biological characteristics indicate, H7N9 avian influenza virus to humans remains a major threat to the H7N9 continued close monitoring and research in order to allow humans have to resist This new recombinant viruses.

This spring, the Chinese come and gone H7N9, exactly what are the "secret"? Yesterday, the Beijing News reporter Shu Yuelong exclusive dialogue with the "Nature" magazine synchronization opened to the public in the dark side of H7N9.

[Infectious]

H7N9 vulnerable people who can not infect humans

Beijing News: This year the H7N9 outbreak seems to have ended?

Shu Yuelong: I firmly believe, H7N9 avian influenza virus in poultry is still popular among asymptomatic.

Beijing News: Now the virus to carry out research mainly focus on what areas?

Shu Yuelong: This new reassortant viruses have a lot of mystery that we have not solved, for example, why the sudden emergence of the virus? Why would infect humans? Will not transmissible among humans? Why most infected illness so heavy? H7N9 outbreak in humans in future What is the risk? This is the main problem we are studying.

Beijing News: What are some of these new research findings?

Shu Yuelong: We found that H7N9 avian influenza virus is with the "sides" of the virus, both like the seasonal flu virus, easy and human upper respiratory tract, such as tracheal cells combined; also equipped with highly pathogenic avian influenza virus of H5N1 characteristics, people can go to the lower respiratory tract and the lungs cell receptor binding. This finding explains why H7N9 H5N1 more susceptible than people.

Beijing News: the more susceptible people, do you mean the possibility of human to human transmission occurs H7N9, H5N1 is much greater than that?

Shu Yuelong: Not necessarily. Because our study also found that, H7N9 avian influenza virus replication in human tracheal low capacity, much lower than the ability to replicate in the lungs, which led directly to H7N9 avian influenza virus is not yet effective human transmission.

Beijing News: Influenza viruses change quickly, if there is one day, H7N9 mutations, it will have the ability to person to person?

Shu Yuelong: This is most likely. Therefore, we are on the one hand to study and find out the person's upper and lower respiratory H7N9 replication efficiency of different reasons such as scientific issues, the other hand to strengthen the monitoring, always find the virus to mutate.

[Virulence]

Virus causes severe hyperimmune cited

Beijing News: You are in "Nature" magazine article mentioned, H7N9 infection in humans will happen "cytokine storm", causing symptoms of infection in critically ill. What is a "cytokine storm"?

Shu Yuelong: When the H7N9 avian influenza virus infection in people after the body's immune system will automatically start to resist. But when there is excessive, intense immune response disorder, it will cause a lot of abnormally elevated cytokine expression, thus causing pathological damage to human tissue. This phenomenon has been aptly called a "cytokine storm."

Beijing News: "cytokine storm" in other influenza virus who have not come across?

Shu Yuelong: H5N1 infection in people, he will rise to a "cytokine storm." This explains why the H7N9 and H5N1 avian influenza virus infection in people after heavier than the symptoms, mortality is also high. Of course, the "cytokine storm" just cause infections occur in critically ill one of the main symptoms. There is a chronic infection itself, can lead to exacerbations. Also, what kind of person, there will be immune overreaction, now is not very clear.

Beijing News: "cytokine storm" can find ways to curb?

Shu Yuelong: Under certain conditions, reduce the immune response may inhibit the "cytokine storm" is valid. Such as Tamiflu and other neuraminidase inhibitor class of drugs for the H7N9 avian influenza infection in clinical treatment is effective, but there have been a pair of Tamiflu-resistant virus, once it will affect the anti-viral drug treatment should therefore be closely monitored its drug resistance.

[Prevention]

H7N9 whereabouts of the "hidden" difficult to find out

Beijing News: the very real problem, do you think this year, autumn and winter, H7N9 will comeback do?

Shu Yuelong: I think it would, because the virus does not disappear automatically.

Beijing News: Reserve now developed a vaccine against H7N9 is very urgent?

Shu Yuelong: very urgent. So far, the world has not yet developed H7N9 vaccine success. Development of vaccines, with such technical reserves, and future people else fight this vaccine are two different things.

Maybe for H7N9 vaccines have been developed, never be used, but as a national public health system, to protect public health, need to have this ability to withstand potentially dangerous.

Beijing News: Why human H7N9 infections were more severe symptoms, but the infection of H7N9 in poultry almost asymptomatic?

Shu Yuelong: This is the most confusing and worrying doubts, but also H7N9 dark side. Although it is on the route of infection with H5N1, there are many similarities, but is completely different, H5N1 on poultry and people, can bring fatal injuries. So, when H5N1 struck, people can more clearly see where it is; while H7N9 in poultry popular among not the disease, it is difficult to ascertain its whereabouts. Just like a "black box", how to open the "black box", agriculture and health sectors need to work together to find the "key."

Beijing News: Now is not the epidemic, do you think that how to track H7N9?

Shu Yuelong: I appeal to health and agriculture departments should strengthen active surveillance for H7N9, including active surveillance among poultry, as well as in human syndromic surveillance. Our country is now established a comprehensive monitoring system for influenza-like symptoms, and unexplained pneumonia reporting system. If a person has flu-like symptoms, unexplained pneumonia, if the reasons for other viral infections were excluded, what should be screened for H7N9 infection. Calm the nation's public health system does not mean you can sit back and relax.

Beijing News: In the group of healthy birds, monitor H7N9 easy to do it?

Shu Yuelong: not easy, but I hope that the agricultural sector can be sustained in animals active surveillance.

Beijing News: It is necessary to carry on the healthy population screening for H7N9 do?

Shu Yuelong: not necessary.

Beijing News Reporter Wei Ming words

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