25 Jun 2013

Novel cyclovirus - Multistate - central nervous system infections (ECDC/CDTR, June 25 2013, edited)

[Source: European Centre for Disease Prevention and Control (ECDC), full PDF document: (LINK). Extract.]

COMMUNICABLE DISEASE THREATS REPORT

Week 25, 16-22 June 2013

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New! Novel cyclovirus - Multistate - central nervous system infections

Opening date: 19 June 2013

 

Epidemiological summary

A mBio article published on 18 June 2013 described the identification of a novel cyclovirus, named CyCV-VN, in cerebrospinal fluid (CSF) specimens from two Vietnamese patients with central nervous system (CNS) infections of unknown etiology. Subsequently CyCV-VN was detected in 26 of 642 (4%) acute-infection CSF specimens (collected from 1999 to 2009), including 10 of 273 (3.7%) CSF specimens from patients with CNS infections of unknown etiology and 16 of 369 (4.3%) samples from patients in whom laboratory-confirmed CNS infection with other pathogens was established. CyCV-DNA could not be detected in 122 CSF specimens collected from Vietnamese patients with noninfectious neurological disorders. CyCV-VN DNA was also detected in 8/188 (4.2%) fecal specimens from healthy children. When specimens from poultry and pigs were tested, the virus was detected in 38/65 (58%).

Another article published online on 10 June 2013 in Emerging Infectious Diseases described the detection of cyclovirus in eight (15%) of 54 serum samples and 4 (10%) of 40 CSF samples from paraplegia patients in Malawi.

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ECDC assessment

This is the first time that cyclovirus is associated with human infection. However further studies are needed in order to definitively establish a causal relationship.

 

Actions

ECDC is preparing a Rapid Risk Assessment of these findings.

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