[Source: Antimicrobial Agents and Chemotherapy, full text: (LINK). Abstract, edited.]
NDM-8 Metallo-β-Lactamase in a Multidrug-Resistant Escherichia coli Strain Isolated in Nepal
Tatsuya Tada 1, Tohru Miyoshi-Akiyama 1, Rajan K. Dahal 3, Manoj K. Sah 3, Hiroshi Ohara 2, Teruo Kirikae 1 and Bharat M. Pokhrel 3
Author Affiliations: 1Department of Infectious Diseases, Research Institute 2Department of International Medical-Cooporation, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku, Tokyo 162-8655 3Department of Microbiology, Institute of Medicine, Tribhuvan University, Maharajgunj, Kathmandu, Nepal
A novel metallo-β-lactamase, NDM-8, was identified in a multidrug-resistant Escherichia coli isolate, IOMTU11 (NCGM37), obtained from the respiratory tract of a patient in Nepal. The amino acid sequence of NDM-8 has substitutions at positions 130 (Asp to Gly) and 154 (Met to Leu) compared with NDM-1. NDM-8 showed enzymatic activities against β-lactams similar to those of NDM-1.
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