22 Feb 2013

Obesity and susceptibility to severe outcomes following respiratory viral infection (Thorax, abstract, edited)

[Source: Thorax, full text: (LINK). Abstract, edited.]

Thorax doi:10.1136/thoraxjnl-2012-203009

Chest clinic / Basic science for the chest physician

Obesity and susceptibility to severe outcomes following respiratory viral infection

Mark H Almond 1,2, Michael R Edwards 1, Wendy S Barclay 2, Sebastian L Johnston 1

Author Affiliations: 1Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, UK 2Department of Influenza, Imperial College London, London, UK

Correspondence to Professor Sebastian L Johnston, Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK; s.johnston@imperial.ac.uk

Received 21 January 2013  - Accepted 1 February 2013  - Published Online First 22 February 2013

 

Abstract

During the 2009 H1N1 influenza pandemic, obesity was convincingly identified as a novel, independent risk factor for multiple markers of disease severity. Associations between numerous nosocomial and community-acquired clinical infections have previously been established; yet, little is known about the mechanisms underpinning the increased susceptibility to severe outcomes following pandemic H1N1/09 infection in obesity. Here, we present a brief synthesis of the recent advances in our understanding of the immunomodulatory effects of obesity on outcomes following respiratory viral infection, with a particular focus on pandemic influenza.

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