[Source: Thorax, full text: (LINK). Abstract, edited.]
Chest clinic / Basic science for the chest physician
Obesity and susceptibility to severe outcomes following respiratory viral infection
Mark H Almond 1,2, Michael R Edwards 1, Wendy S Barclay 2, Sebastian L Johnston 1
Author Affiliations: 1Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, UK 2Department of Influenza, Imperial College London, London, UK
Correspondence to Professor Sebastian L Johnston, Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK; firstname.lastname@example.org
Received 21 January 2013 - Accepted 1 February 2013 - Published Online First 22 February 2013
During the 2009 H1N1 influenza pandemic, obesity was convincingly identified as a novel, independent risk factor for multiple markers of disease severity. Associations between numerous nosocomial and community-acquired clinical infections have previously been established; yet, little is known about the mechanisms underpinning the increased susceptibility to severe outcomes following pandemic H1N1/09 infection in obesity. Here, we present a brief synthesis of the recent advances in our understanding of the immunomodulatory effects of obesity on outcomes following respiratory viral infection, with a particular focus on pandemic influenza.