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20 Feb 2013

Extended-Spectrum CTX-M-15-Producing Klebsiella pneumoniae ST274 in Companion Animals (Antimicrob Agents Chemother., abstract, edited)

[Source: Antimicrobial Agents and Chemotherapy, full text: (LINK). Abstract, edited.]

Extended-Spectrum CTX-M-15-Producing Klebsiella pneumoniae ST274 in Companion Animals

Laurent Poirel 1, Patrice Nordmann 1,*, Sébastien Ducroz 1, Henri-Jean Boulouis 2, Pascal Arné 3 and Yves Millemann 4

Author Affiliations: 1Service de Bactériologie-Virologie, INSERM U914 «Emerging Resistance to Antibiotics», Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K.-Bicêtre 2Laboratoire de Microbiologie 3UMR Bipar, Ecophar 4Unité Microbiologie Alimentaire, Sécurité et Qualité des Aliments (MASQ), Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, Maisons-Alfort, France



Screening of extended-spectrum ß-lactamase (ESBL)-producing Gram-negatives in companion animals living in the Paris area in France identified a high rate of CTX-M-15-producing Klebsiella pneumoniae. Those isolates were recovered during the 2010-2011 period from both infections and asymptomatic colonization. Sequence typing revealed that most of these isolates belonged to sequence type ST274. Interestingly, the blaCTX-M-15 gene was located on a specific and novel plasmid scaffold. These findings highlight that companion animals may be reservoirs for CTX-M-15-producing K. pneumoniae evolving separately from the human reservoir of CTX-M-15 producers.



* Corresponding author. Mailling address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 76 rue du général Leclerc, 94275 Le Kremlin-Bicêtre cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail:

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