[Source: Antimicrobial Agents and Chemotherapy, full text: (LINK). Abstract, edited.]
Antimicrobial Activity of Ceftaroline-Avibactam Tested Against Recent Clinical Isolates from USA Medical Centers (2010-2011)
Helio S. Sader 1,#, Robert K. Flamm 1 and Ronald N. Jones 1,2
Author Affiliations: 1JMI Laboratories, North Liberty, Iowa, USA 2Tufts University School of Medicine, Boston, Massachusetts, USA
Ceftaroline-avibactam and comparator agents were tested by broth microdilution method against 20,089 isolates consecutively collected in 2010 and 2011 from 75 USA medical centers. Ceftaroline-avibactam was active against Enterobacterieaceae (4,908 strains; MIC90, 0.25 μg/mL and highest MIC, 4 μg/mL), including meropenem-non-susceptible Klebsiella spp. and ceftazidime-non-susceptible Enterobacter cloacae strains (MIC90, 1 μg/mL for both). Ceftaroline±avibactam was also active against ceftriaxone-non-susceptible Streptococcus pneumoniae (MIC90, 0.25 μg/mL) and methicillin-resistant Staphylococcus aureus (MIC90, 0.25 μg/mL).
#Corresponding author: Helio S. Sader, MD, PhD, JMI Laboratories, 345 Beaver Kreek Ctr, Ste A, North Liberty, Iowa, 52317, USA, Phone: 319-665-3370, Fax: 319-665-3371, firstname.lastname@example.org
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