19 Jan 2013

Selective serotonin reuptake inhibitor fluoxetine inhibits replication of Human Enterovirus B and D by targeting viral protein 2C (Antimicrob Agents Chemother., abstract, edited)

[Source: Antimicrobial Agents and Chemotherapy, full text: (LINK). Abstract, edited.]

Selective serotonin reuptake inhibitor fluoxetine inhibits replication of Human Enterovirus B and D by targeting viral protein 2C

Rachel Ulferts 1, Lonneke van der Linden 2,3, Hendrik Jan Thibaut 3, Kjerstin H.W. Lanke 2, Pieter Leyssen 3, Bruno Coutard 4, Armando M. de Palma 3, Bruno Canard 4, Johan Neyts 3 and Frank J.M. van Kuppeveld 1,*

Author Affiliations: 1Department of Infectious Diseases and Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands 2Department of Medical Microbiology, Virology Section, Nijmegen Centre for Molecular Life Sciences & Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands 3Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium 4Aix-Marseille Université, CNRS, AFMB UMR 7257, 13288, Marseille, France

 

ABSTRACT

Although the genus Enterovirus contains many important human pathogens, there is no licensed drug for either treatment or prophylaxis of enterovirus infections. We report that fluoxetine (Prozac©) — a selective serotonin reuptake inhibitor — inhibits replication of human enterovirus (HEV)-B and HEV-D, but does not affect the replication of HEV-A and HEV-C or human rhinoviruses A and B. We show that fluoxetine interferes with viral RNA replication and we identified viral protein 2C as the target of this compound.

 

FOOTNOTES

*Corresponding author. Phone: +31-30-2534173. E-mail: f.j.m.vankuppeveld@uu.nl

Copyright © 2013, American Society for Microbiology. All Rights Reserved.

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