23 Jan 2013

Plasmid Content of a Clinically Relevant Klebsiella pneumoniae Clone from the Czech Republic Producing CTX-M-15 and QnrB1 (Antimicrob Agents Chemother., abstract, edited)

[Source: Antimicrobial Agents and Chemotherapy, full page: (LINK). Abstract, edited.]

Plasmid Content of a Clinically Relevant Klebsiella pneumoniae Clone from the Czech Republic Producing CTX-M-15 and QnrB1

Monika Dolejskaa,b, Laura Villac, Hana Dobiasovaa, Daniela Fortinic, Claudia Feudic and Alessandra Carattolic

Author Affiliations: aDepartment of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic bCEITEC VFU, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic cDepartment of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy

 

ABSTRACT

The entire plasmid content of a multidrug-resistant, CTX-M-15-producing Klebsiella pneumoniae ST416 clone was investigated. Two FIIK plasmids, pKDO1 (127 kb) and pKPN-CZ (207 kb), were identified and found to carry a formidable set of genes conferring resistance to toxic compounds, metals, and antimicrobial drugs and exhibiting novel features putatively associated with adaptation and fitness of the bacterium in the human host.

 

FOOTNOTES

Received 13 September 2012.  - Returned for modification 30 September 2012.  - Accepted 2 December 2012.

Address correspondence to Monika Dolejska, m.dolejska@centrum.cz.

Published ahead of print 10 December 2012

Supplemental material for this article may be found at http://dx.doi.org/10.1128/AAC.01886-12.

Copyright © 2013, American Society for Microbiology. All Rights Reserved.

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