24 Jan 2013

Laboratory-based surveillance in the molecular era: the TYPENED model, a joint data-sharing platform for clinical and public health laboratories (Euro Surveill., abstract, edited)

[Source: Eurosurveillance, full text: (LINK). Abstract, edited.]

Eurosurveillance, Volume 18, Issue 4, 24 January 2013

Surveillance and outbreak reports

Laboratory-based surveillance in the molecular era: the TYPENED model, a joint data-sharing platform for clinical and public health laboratories

H G Niesters1, J W Rossen1,2, H van der Avoort3, D Baas3, K Benschop3,4, E C Claas5, A Kroneman3, N van Maarseveen6, S Pas7, W van Pelt3, J C Rahamat-Langendoen1, R Schuurman6, H Vennema3, L Verhoef3, K Wolthers4, M Koopmans ()3,7

  1. Department of Medical Microbiology, Division of Clinical Virology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
  2. Laboratory for Medical Microbiology, St Elisabeth Hospital, Tilburg, the Netherlands
  3. Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands
  4. Department of Medical Microbiology, Academic Medical Center, Amsterdam, the Netherlands
  5. Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands
  6. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands
  7. Department of Virology, Erasmus Medical Centre, Rotterdam, the Netherlands

Citation style for this article: Niesters HG, Rossen JW, van der Avoort H, Baas D, Benschop K, Claas EC, Kroneman A, van Maarseveen N, Pas S, van Pelt W, Rahamat-Langendoen JC, Schuurman R, Vennema H, Verhoef L, Wolthers K, Koopmans M. Laboratory-based surveillance in the molecular era: the TYPENED model, a joint data-sharing platform for clinical and public health laboratories . Euro Surveill. 2013;18(4):pii=20387. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20387
Date of submission: 28 June 2012


Laboratory-based surveillance,  one of the pillars of monitoring infectious disease trends, relies on data produced in clinical and/or public health laboratories. Currently, diagnostic laboratories  worldwide submit strains or samples to a relatively small number of reference laboratories for characterisation and typing. However, with the introduction of molecular diagnostic methods and sequencing in most of the larger diagnostic and university hospital centres in high-income countries, the distinction between diagnostic and reference/public health laboratory functions has become less clear-cut. Given these developments, new ways of networking and data sharing are needed. Assuming that clinical and public health laboratories may be able to use the same data for their own purposes when sequence-based testing and typing are used, we explored ways to develop a collaborative approach and a jointly owned database (TYPENED) in the Netherlands.  The rationale was that sequence data – whether produced to support clinical care or for surveillance –can be aggregated to meet both needs.  Here we describe the development of the TYPENED approach and supporting infrastructure, and the implementation of a pilot laboratory network sharing enterovirus sequences and metadata.

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