31 Dec 2012

Amyotrophic lateral sclerosis and organ donation: Is there risk of disease transmission? (Ann Neurol., abstract, edited)

[Source: Annals of Neurology, full page: (LINK). Abstract, edited.]

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Amyotrophic lateral sclerosis and organ donation: Is there risk of disease transmission?

Brandon B. Holmes BA, Marc I. Diamond MD*

Article first published online: 31 DEC 2012 - DOI: 10.1002/ana.23684

Copyright © 2012 American Neurological Association

Annals of Neurology - Volume 72, Issue 6, pages 832–836, December 2012 - Holmes, B. B. and Diamond, M. I. (2012), Amyotrophic lateral sclerosis and organ donation: Is there risk of disease transmission?. Ann Neurol., 72: 832–836. doi: 10.1002/ana.23684

Author Information: Department of Neurology, Hope Center for Neurological Disorders, Washington University in St Louis, School of Medicine, St Louis, MO - Email: Marc I. Diamond MD (diamondm@neuro.wustl.edu)

*Department of Neurology, Hope Center for Neurological Disorders, Washington University in St Louis, School of Medicine, Biotechnology Building, Room 111, 4559 Scott Ave, St Louis, MO 63110

Publication History: Issue published online: 31 DEC 2012  - Article first published online: 31 DEC 2012  - Accepted manuscript online: 10 JUL 2012 12:01PM EST  - Manuscript Accepted: 26 JUN 2012  - Manuscript Revised: 23 JUN 2012  - Manuscript Received: 31 MAY 2012

 

Abstract

A new protocol suggests that patients with amyotrophic lateral sclerosis (ALS) are a viable source of tissue for organ transplantation. However, multiple lines of evidence suggest that many neurodegenerative diseases, including ALS, might progress due to transcellular propagation of protein aggregation among neurons. Transmission of the disease state from donor to host thus may be possible under the permissive circumstances of graft transplantation. We argue for careful patient selection and close longitudinal follow-up of recipients when harvesting organs from individuals with neurodegenerative disease, especially dominantly inherited forms. ANN NEUROL 2012;72:832–836

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