6/26/2009

USA. CDC Press Briefing Transcripts June 26, 2009 (edited)

Press Briefing Transcripts

CDC Telebriefing on Investigation of Human Cases of Novel Influenza A (H1N1) - June 26, 2009, 1 p.m. ET


Operator:
During the question and answer session today, you can press star 1 to ask a question. Today's conference is being recorded. At this time I'll turn the call to Mr. Joe Quimby. You may begin.

Joe Quimby:
Hi, good afternoon to everyone. With us today is Dr. Anne Schuchat, the director of National Center for Immunization and Respiratory Diseases at the Centers for Disease Control and Prevention here in our headquarters in Atlanta. Dr. Schuchat?

Anne Schuchat:
Thank you, good afternoon, everyone. We've just completed 2 and a half days of our Advisory Committee on Immunization Practices, a lot of which did focus on the novel H1N1 influenza virus and so what I want to do this afternoon is briefly give you a situation update about what is going on here in the United States, a little bit about the Southern Hemisphere and provide a few pieces of information related to vaccine planning.

The novel H1N1 influenza is continuing to spread here in the United States and around the globe. What we're seeing is varying by region in the United States and in different countries. The key point is that this new infectious disease is not going away. In the U.S., we're still experiencing a steady increase in the number of reported cases. Of course, reported cases are really just the tip of the iceberg. The number of new cases that were reported to us this past week was actually the largest number we've had reported since the beginning of the outbreak. Today, we're describing the 27,717 lab-defined cases have been reported to us here in the U.S., including over 3,000 hospitalizations and 127 fatalities. There were more than 6,000 of these cases reported to us within this past week. W.H.O. is now reporting almost 60,000 cases of this new virus in more than 100 countries and they report being aware of 263 deaths. Here in the U.S., 12 states are reporting widespread influenza activity, those include Arizona, Connecticut, Delaware, Hawaii, Maine, New Jersey, New York, Pennsylvania, Rhode Island, Utah and Virginia. And you'll notice some of those states have been having widespread activity for a while and some of the states that had widespread activity a while ago, like Texas or California, aren't actually on that list right now. It's very unusual for this time of year to still be having so many states reporting regional and widespread activity and that's just one feature that helps us know that what we're seeing this year is quite different than what we usually see with seasonal influenza.

In terms of the virologic testing that's being done, the new H1N1 virus is now making up more than 99% of all the typed isolates we're testing here in the U.S. with our collaborating laboratories, so virtually all the of the influenza that's circulating that's getting a diagnosis is this new strain right now here in our summer months. We're also tracking milder illness, outpatient visits for what we call influenza-like ill this and this is now returning below the national baseline but in -- at the national level, but two of our ten regions of the country are still above what we think of as a baseline for this time of year. Those two regions are New England and the New Jersey/New York area, regions 1 and 2, where they're still seeing more influenza-like illness than you would expect to see at this time of year. Those regional numbers can mask outbreaks of clusters at smaller geographic areas and we know some communities are still coping with outbreaks of this disease.

Influenza-like illness increase during week 24 in 6 of the 10 regions compared to week 23. That's unusual. Usually this time of year, things would be going down instead of going up. As you may have heard yesterday, we at CDC are estimating that those reported cases are really just the tip of the iceberg. We're saying there have been at least a million cases of this new H1N1 virus in the United States so far this year. That's really not a perfectly accurate estimate. It's just a number, a ballpark figure, that we think for sure there's been more than a million of these new infections. We know we're not tracking every single one of them. There have been community surveys in a couple of areas looking at influenza-like illness in areas where we know there's a lot of the strain circulating and in many of those communities, they're reporting proportions of about 6% of their community members having had an illness that's consistent with the new virus.

I want to just briefly next some clinical features.

We continue to say there most of the impact of this new virus is affecting younger people compared with what we see with the seasonal flu when, of course, seniors, people over 65, are so greatly affected. We're seeing high rates of illness among people under 50. The highest rates are in those under 25.

When we look at hospitalized cases, nearly 80% of people who have been hospitalized in the U.S. and reported to us have been under 50. The median age of hospitalized cases is 19 years old.

When we look at the most severe outcomes, the people who have died, the age is a bit older. The median age of those who have died is 37, still quite young for anyone to be dying of an infectious disease, but a bit older than the hospitalizations and the average cases. We think it's important for everyone to be aware of this new virus that's circulating in so many parts of our country and the world, but it's particularly important for those of us who have underlying health conditions. We might think of these as big problems because they're just part of our day-to-day life, but people with asthma, people with diabetes, heart disease, people with chronic lung disease and, of course, people who are pregnant night to be especially concerned if they develop respiratory symptoms, fever and a respiratory illness. You've heard us talking about obesity and sometimes we talk about what doctors call more bid obesity or extreme obesity. That's showing up in our lists of people who are hospitalized with this condition and among some of the deaths that we're seeing. We want to clarify that.

We think that people who are severely obese, the extreme obesity or what doctors called [more bid [morbid]] obesity are people who also have chronic lung disease. The heavy weight that people are carrying around can compromise the lungs and can put you at risk for influenza, so it's not really a new risk factor for influenza, it's just a repackaging of that chronic lung disease that we've always known was a risk for influenza. I want to mention a particular feature that we've been hearing about this past couple weeks and that's outbreaks of influenza occurring in summer camps.

Earlier in the spring, we were talking to you about outbreaks in schools and now, the state health departments are letting us know about a number of outbreaks in summer camps that are affecting people, both children, teenagers and adults associated with these camp communities. It's quite unusual to have this many outbreaks of influenza in camps, but it's not actually that unexpected given the continuing spread of this virus and the fact that when at-risk people congregate in close quarters, it's easier for things to spread.

We are aware of 34 outbreaks of the novel H1N1 virus occurring in 16 states around the country and this is an important issue for public health and for parents to be aware of. Camps have taken a number of steps to reduce illness among their campers and their staff. They're isolating sick campers from others. Some have delayed sessions or sent kids home who were ill. Some have actually closed for the summer. And we want to make sure people know that we have guidance about Congress with this new virus in the summer camp setting that's on our website at www.cdc.gov. Of course for camps that are catering to children with medical conditions, that's a particular concern because those children are so vulnerable.

Next I want to briefly mention the Southern Hemisphere.

We talked to you a lot in the weeks that passed about our keen interest in what would happen in the Southern Hemisphere as influenza continues to circulate because the Southern Hemisphere, of course, is going into their winter season, their flu season. There are reports of this new H1N1 virus circulating at the same time as the seasonal H3N2 influenza viruses and other influenza viruses in the southern Hemisphere. They're outbreaks of the new virus that have been reported from several countries. There's significant numbers or cases that have been reported in particular from Australia and on Argentina and Chile and in some of these places we have heard reports that the health care settings are actually having difficulty coping with the numbers of people coming in, so just as we saw some challenges here in cities around the country in the U.S., some of the Southern Hemisphere countries are also having that type of challenge with the onslaught of these new cases of illness.

We do expect that this new strain is going to continue to spread in the Southern Hemisphere and intensify over the weeks ahead and we are continuing to watch this closely. We'll be watching for changes in the virus.

We have not seen any changes in the virus that are important as of this point.

We'll also be watching for changes in disease patterns. We've mentioned that people over 65 don't seem to be getting this illness or getting it in very great numbers here in the U.S. We'll be watching to see whether older people start to get this virus in the Southern Hemisphere as the flu season progresses. Those kinds of concerns have not shown up yet but we're continuing to watch.

We'll also be continuing to watch the virus to see if it develops resistance to the oseltamivir type of drugs. We haven't seen that yet but it's the kind of thing we'll continue to look for.

Lastly, I want to say a few things about vaccines. We've told you in the past that vaccine development is going on in the U.S. Five manufacturers are working on this particular strain of influenza, making candidate vaccines that can be tested in clinical trials that will be happening over the summer months. And then, as many of you know, the CDC hosted our regular advisory committee on immunization practices here in Atlanta the past couple days and we had two sessions devoted to the novel H1N1 virus and really, the pandemic planning in general. It's too early for decisions by the ACIP about who might get this new vaccine that's being worked on or for specific target groups to be clarified. It's really important that we have open and candid discussions about the planning and that's what went on here in Atlanta.

A very thorough set of presentations about vaccine development, virologist, about the guidance is important pandemic influenza vaccination that are being developed over the last few years, re-evaluation of that guidance in light of the scenario we are seeing today. Were heard about the plans for tracking vaccine effectiveness and vaccine safety and about the public health issues related to implementing immunization program against this new virus, a pandemic virus. It was a good meeting with a healthy set of discussions.

I want to let you know a few of the features of the discussion. Although we haven't made decisions about actual vaccination and who will be vaccinated should a safe and effective vaccine be developed and available, it's very important for states and communities to begin intensifying their efforts on planning to administer a vaccine should such be necessary in the fall. So, we want to do what we can to help states and local health departments and the partners within their communities move forward in that planning. We want states and communities to be ready to offer and administer the vaccine should one become available against this novel H1N1 virus and to help with that, we expect to be providing specific planning scenarios to states and communities that they can use in trying to understand which populations they'll need to be reaching. While the CDC and our partners have not finalized those planning scenarios, based on what we're currently seeing with respect to the virus and the epidemiology, we want states and communities and health care providers to be thinking about how they would be able to vaccinate younger people, pregnant women, people who have underlying health conditions like diabetes and answer ma that put them at higher risk from severe complications from this new influenza virus so the idea that this virus has been greatly affecting young people including school children, pregnant women, babies, and adults, particularly younger adults with those underlying conditions, those are the kind of populations that the state, local and health care providers can really begin thinking about.

That action doesn't mean we've finalized any vaccine recommendations. Of course, we'll be looking to the advice of the advisory committee on immunization practices and other stake holders as well as the public as we move forward in our plan, but it's very important for planning to go on and to move forward expeditiously because if we do need to vaccinate, we'll need to have good plans in place. So, in some way, this influenza virus, this new H1N1 virus that the W.H.O. has declared to be pandemic, is not going away. It's continuing to cause illness, deaths and outbreaks here in the U.S. and it's causing illness in the Southern Hemisphere in great numbers. The government and public health are busy taking steps to be ready to respond to this virus as we see what happens in the fall and to be ready for a great increase in the illness and outbreaks that this virus will cause. We want communities and families to also be thinking ahead about how they can ready themselves to cope with this virus should increased illness and community outbreaks occur.

Coordinated planning is important and this is a partnership really between government, the private sector and the public and it's also important that we coordinate between the federal, state, local and really community levels and those are the kinds of efforts that we're going to be focusing on over the weeks ahead so, I think I'll stop with that and answer questions that you have.

Joe Quimby:
Operator, ready for questions.

Operator:
Thank you, just tell me if you'd like to ask a question, press star 1. Again, press star 1. And one moment, please. Our first question comes from David brown with the Washington Post, you may ask your question.

David Brown:
Yeah, thanks a lot for this. Some people around here in Virginia, which is one of the states with widespread flu activity, are wondering why, when they take a kid to the E.R. with a 105 fever, headache, you know, seems pretty sick, get tested and they're positive for influenza, there's no further testing to nail down that it's the novel H1N1. Can you sort of explain a little bit more why definitive diagnosis is not useful in -- at this stage in the epidemic or when it is useful?

Anne Schuchat:
Yes, thank you. Of course, parents want to know what's wrong with their children and I think we've been paying so much attention to this new virus that it's very understandable that as an individual family, you'd want to know whether that's what your child has. We have to step back and think about the implications of that answer and also the epidemiological needs the public needs to know what's going on and the reality that tests are not an unlimited capacity right now. Fortunately, we don't have a simple test that can be done at the bedside that differentiates this particular virus from other viruses. Fortunately, we have a new test that can be done in state and public health laboratories that can differentiate this new virus from other viruses but there's really not the sufficient number of those tests or the capacity in terms of the people to do those tests to test every single person who has an influenza-like illness. I mentioned earlier we're estimating more than a million people probably have gotten this infection, but with don't typically get a laboratory answer on every single person with influenza each year. Now, for clinicians, it's very important that they recognize influenza-like illnesses and that, if people are at high risk for complications, that we think it's important that they offer antiviral medicines to treat those illnesses, so that's one reason why you want to know what's going on but it may not help you to get a lab test back several days from now in terms of an antiviral treatment. We think it's also very important to look at the types of viruses that are circulating in communities around the country and that's one of the reasons we do virologic sampling. We do virology testing of influenza-like illness. Not every single one of them, but a sample. So what we're trying to do is make sure we have very good, accurate, timely information for the country and for specific regions, but not, unfortunately, the capacity that every single individual child or adult with an illness that may be this new one. Next question?

Operator:
Thanks, next question comes from Fergus Walsh with the BBC. You may ask your question.

Fergus Walsh:
Yes, thank you very much for taking my question. A couple of points. I just wanted to check in the UK, everyone who's suspected of having the H1N1 virus is offered antivirals and I wanted to see what the policy was in the U.S. And secondly, just one quick clarification on what Lyn Finelli was saying yesterday. I've got a quote here where she was talking about people over 65 and I just want to check this because she said, it seems to be deadliest to people 65 and older with deaths in more than 2% of elderly people infected and that kind of jumped out to me because I thought very, very few people over 65 were getting it. I just wondered if you could clarify that for me, please.

Anne Schuchat:
Yes, thank you. In the U.S., our antiviral recommendations are based on the observation that the vast majority of people who get this new virus have illness that is mild and clears on its own or they have illness that gets better. It's not mild, you can be quite miserable in bed for a few days, but it doesn't lead to complications in most people. On the other hand, pregnant women, people with underlying medical conditions like asthma and diabetes, can have a much worse outcome. They can get pneumonia. They can have severe hospitalizations and, of course, some of them are dying. So, the strategy here in the United States is to focus the antiviral treatment on people who have those conditions that put them at much greater risk of a complication. Babies, people who are pregnant, have those underlying conditions. Now, I want to clarify the issue about people over 65 because I think these numbers can get very confusing. Very few cases that we are seeing are occurring in people 65 and over. Very few hospitalizations that we're seeing are occurring people 65 and over. In fact, there are only 6% of all of the cases in one of our hospitalization series occur in people over 65 and that was in only 15 people in that one series. In that same series, 35% of the hospitalizations were occurring in people 18 to 49. Now, when you have a very small number, the proportion that died may not be that accurate. So, I think what Dr. Finelli was trying to say was that we have a -- the majority of our cases are in the very young. Our hospitalizations are in young people. Very few people over 65 are getting this, but if they do get this, their chance of dying is a bit greater. Now, that's not really that surprising that, in the rare times when somebody over 65 gets this virus, between their age and the many other medical conditions that they may have, they may have a worse time of it, but in terms of our really putting our arms around the problem, this is much more of a problem in younger people with very low rates of disease, hospitalizations and so forth in the oldest population. I hope that clarifies things. Next question?

Operator:
Our next question comes from Daniel DeNoon with WebMD. You may ask your question.

Dan DeNoon:
Thank you. Dr. Schuchat, can you elaborate a little more on the experience in the Southern Hemisphere, particularly the overwhelming of some health care institutions. As we heard at ACIP, there's a lot of concern at the local level and even at the state level of a lack of funding that makes us a good bit less prepared than perhaps we'd like to be. Are these situations in the Southern himself steer analogous and are there lessons to be learned for us in.

Anne Schuchat:
I think the situation in the Southern Hemisphere is evolving and we are looking closely with partners in those case and with the world health organization, pan-American health organization, to support the effort and also to get as good information as we can. Now, remember that we have had some challenges here in the U.S. with lines in emergency departments and it being difficult to get into your doctor's office to be seen, and when we have the respiratory season, that can happen anyway. I think what may be going on in some of these Southern Hemisphere countries ask, as the virus is recognized and people are trying to figure out, do I have it, is my illness that I may or may not usually go seek health care for something that I really need to seek health care for, there's probably what we think of as the worried sick. You know, people who are ill who might not usually have sought health care who may be seeking health care. On the other hand, there probably are more illnesses and so, as we work together with people in Mexico and as we worked in communities here in the United States, it can take some time to tease out true increases in severe disease, mild or moderate disease, and then an increase in the illness that's presenting to health care. We've had to make some changes in our recommendations here at the national level, as you know? Some of the affected cities, they really changed their warnings which people they suggested call their doctor or go to the emergency department which people needed to be alert for the illness requiring medical shift and I believe in the Southern Hemisphere countries, there's a little bit of that going on. Now, there are, of course, some areas around the world are people are having particular problems trying to handle severe illness in places where there may not be enough life support for those kinds of illnesses, but that's not as well confirmed at this point and I think we're really in early days trying to tease that out. Next question?

Operator:
Next question comes from Helen Branswell with the Canadian Press. You may ask your question.

Helen Branswell:
Thank you very much. I was hoping I could ask couple of questions if I could. The first one is, did the CDC have an estimate as this point of how many people who die have underlying conditions? We had earlier heard maybe as many as half of the people who were dying were previously healthy, but increasingly, it seems like all of the death notices, almost all of the death notices have reference to underlying conditions. And the second question I wanted to ask is are you doing any sero surveys in parts of the U.S. to try to get a better handle on how many people have been infected in this wave?

Anne Schuchat:
Yes, thank you. The vast majority of the fatalities that we hear of or that are officially reported to us do occur in people with underlying conditions. It's not 100%. It's more on the on order of three-fourths of them at this point. We're continuing to track that and get additional information. We're up to 127 deaths have been reported to us, but we don't have that underlying condition information yet on all of them. But it's the majority but I think it's important for people to recognize that we do have some reports of deaths in people who don't have any underlying conditions, so most of the people who are dying are those with another condition, but as I said, they tend to be relatively young and I don't think that they were thinking of themselves as ready to die. So, this is a serious virus, one that we are taking quite seriously. You had a second question I'm trying to remember.

Helen Branswell:
Serology.

Anne Schuchat:
About the serology, right. We are working on serologic assays and we are doing, in the midst of serologic surveys, there's a number of ways that those assays would be evaluated. We're working with Mexico on understanding the, what we call the bottom of the pyramid, people who might have had milder illness are really asymptomatic illness but have been exposed and infected with this virus without actually knowing it. We're doing that in some of the areas here in the U.S. that have been affected. We've actually got some projects going on in the households where people have had an illness to understand what kind of spread there is in the family, both symptomatic and asymptomatic spread, so there's a number of settings where we're trying to understand really how much infection is around a particular case or an outbreak that we're seeing. This, the ser logic testing is rather complicated. It's not a quick type of test. So those tests are -- those studies are ongoing, but we don't expect to have results in the days ahead. They're something that we're working on quickly, but they won't be results we'll be able to share within the next several days for sure. Our next question, please?

Operator:
Thank you, next question comes with Betsy McKay with the Wall Street Journal. You may ask your question.

Betsy McKay:
Thank you, Dr. Schuchat. I had a question about the mild end of this disease. In other words, how mild do you think the presentations of this disease could be and as part of that, who are some of these 1 million or more than 1 million people do you think, or do you have evidence that there could be people out there who are -- may have only one or two symptoms like a sore throat or a cold but actually have novel H1N1 or there are people who may actually be asymptomatic but are carrying the disease?

Anne Schuchat:
You know, the question about asymptomatic infection is one we don't have an answer yet for. That's where we'll use the serologic testing. We are expecting to see that. It would actually be surprising to me if we did not find asymptomatic infection. We know that influenza viruses can cause a range of spectrum, a range of illness from very, very mild or, as I said, even asymptomatic to much more severe. We have information on presenting symptoms for hospitalizations and the vast majority, of course, have fever and more than 80% have cough, but for the milder cases, there are other symptoms that we're hearing about. You know, of course, sore throat. There is some that we've reported about vomiting and diarrhea occurring in the milder illnesses, but what I'd like to stress is there's a range. Most people, of course, do have fever in terms of the symptomatic illness. Most of the symptoms are in the respiratory category, cough, shortness of Beth or sore throat, but, of course, there are some reports now of the nausea or vomiting, diarrhea-type symptoms in conjunction with confirmed virus. I think the important thing is that if you have severe symptoms or if you have fever and respiratory symptoms and you have one of those medical conditions like asthma, diabetes or certainly if you're pregnant, you need to check with your health care provider because those are signs that you might need treatment and testing. Next question?

Operator:
Thank you, our next question comes from Beth Galvin with Fox 5 Atlanta.

Beth Galvin:
My question was already answered. Thanks, I'll let somebody else go.

Joe Quimby:
Okay, next question.

Operator:
Thank you, next question come from Karen Zietvogel with AFP. Ask your question.

Karin Zeitvogel:
Hi, yes. I was wondering if you could explain a couple of things about the 1 million estimate in the U.S. Is this because a lot of people are walking around as "the Wall Street Journal" journalist just ask with milder infections and just aren't going to get checked and do you do similar modeling because I believe you used the model to arrive at that figure for seasonal flu and if so, where would seasonal flu likely be at this stage because I know we have 36 million cases every year of seasonal flu.

Anne Schuchat:
Okay. We are working with modelers to come up with some estimates. The million is actually estimating the symptomatic. It's not assuming that there's asymptomatic cases, but it is assuming that people are ill with this virus and don't seek medical care and then, of course, as we were saying earlier, many, many people who seek medical care are not tested and many of those who are tested don't get the test -- the additional testing that's needed to show it's this virus rather than another one. We think there's several features of the numbers that are different from seasonal influenza. You know, we say that each year, seasonal influenza viruses in the United States cause an estimated 36,000 deaths, over 200,000 hospitalizations and many million illnesses that don't require hospitalization and don't end up dying. Things that are different about this particular situation is that we have seen illness begin in April and continue to increase. We are estimating about a million people in the U.S. or more have gotten this virus at a time of year where people aren't really continuing to get the seasonal influenza viruses. And so, a big question that everybody really has is, what kind of illness, hospitalization and deaths may we see when our actual winter flu season begins? Will we see a greater number of illness, hospitalization and death from this new virus than we see from any of the individual seasonal influenza viruses? Will we see about the same apartment or will we even see more? And I think it's really important the say that season influenza viruses cause a lot of disease that is important and that causes a burden on our health system and, fortunately, we have vaccines against the seasonal influenza viruses so we strongly recommend use of those seasonal influenza vaccines to prevent the hospitalizations and deaths and outbreaks that we see. I unfortunately can't tell you today whether next fall we're going to see more of this new H1N1 virus than of the other seasonal influenza viruses. We are expecting to have the regular seasonal influenza virus to circulate and we are expecting to want to vaccinate against those rig viruses but as we mentioned, we are producing a vaccine and we are studying it this summer and we are beginning to work with state and local health departments to implement the planning that would be involved on to be ready to vaccinate against this virus should it be needed.

Joe Quimby:
Operator, we have time for two more questions.

Operator:
Our next question comes from Martin Enserink with Science Magazine.

Martin Enserink:
Yes, hello. Thank you for taking my question. I wonder if you could elaborate a little bit more on that model. I mean, how do you get from 27,000 confirmed cases to that estimate of a million or more? And secondly, I think you mentioned the 6%. I wanted to ask you to clarify what that means exactly. Is that the attack rate among household complex or contacts in general? What is that number? And is that high or low compared to seasonal influenza?

Anne Schuchat:
Right. I think that I will give you some answers and then what I'd like to say is that we have modeling in progress and so, as Dr. Finelli mentioned, a number of at least a million. That's actually a preliminary number that's not fully -- I expect it's going to be a bit higher than that when we finish the modeling. I want to mention that in New York City, they did a community survey that suggest the 6.9% of New Yorkers had experienced a flu-like illness during a three-week period in may when from their viralic testing they knew pretty much that most of that influenza-like illness was cause by this new H1N1 strain. They estimated from that about half a million New York City residents may have been infected with this new virus and had that kind of flu-like illness without getting a test or necessarily seeking care. We have carried out similar kinds of phone surveys of communities and we've also been doing some household surveys where there are individuals who are ill looking at the secondary rates in the household. There are communities not driven by the household that came up for the 6% estimate and that's not for the country as a whole, has is for a couple of places where we saw the outbreak really spread through a community. So, we don't know whether many, many, many or every community in the country will go through that kind of experience next year or not. Now, when you compare this to seasonal influenza, I think an important feature is that seasonal influenza is usually happening over weeks to months in a cold winter environment. And we don't know exactly whether what we've seen in the communities that were affected in the spring and summer is like what those same kind of communities would experience in a winter scenario. The attack rate of 6% is low for the seasonal influenza, but it's just a several-week attack rate. That New York City estimate was three weeks in the entire city of New York. So, I think that we believe the attack rates of this new virus, particularly in young people, may exceed the kind of attack rates that we see with seasonal influenza, but one other feature that's important is that we aren't seeing illness in the elderly, even in our household studies, we're really seeing the people over 65 in particular and probably people in their 50s are less likely to get ill with this virus even when they're in a family with somebody who has it. So, in seasonal influenza, of course, quite a bit of the severe burden, the hospitalizations and deaths, cur in the elderly. The attack rate in the high, highest in young people with seasonal flu, but the severe illness is highest in the seniors.

Joe Quimby:
Operator, our last question, please.

Operator:
That comes from Stacey Singer with the Palm Beach Post. You may ask your question.

Stacey Singer:
Thanks for taking the question. I appreciate it up you had mentioned that you're asking communities to start preparing, I guess, for potential vaccination campaign. I'd like to hear a little bit about what that kind of a campaign would look like. Around here, Maxim Health Systems usually distributes the flu shots, the seasonal flu shots if people don't go to the doctors offices. Are we going to see, you know, tables at Costco and grocery stores and things like that or is it going to be different in some way? Thanks.

Anne Schuchat:
You know, that's a great question. The plans that we have right now are that we'll be working closely with the state and local health departments and expect them to be working closely with partners across the state. They may be working with the private sector as you mentioned, the community vaccinators like you mentioned or with some of the private businesses. They may be working with occupational clinics that are typically vaccinating adults. They may be working with the department -- the schools and the department of education in the state to understand what are the best ways to reach school-age children, so I think that there'll be a variety of approaches and what we're trying to do is develop guidance that will help the states and their local -- state and local authorities in their planning and really to encourage communities to start thinking about this. We know that seasonal influenza is really important. The seasonal influenza vaccination campaigns have become a community thing. Many people are not vaccinated in their doctors' offices. They're vaccinated in other places that just work better for them, but the doctors' offices are an important part of the seasonal influenza vaccination campaign, so I think it's a point of intense planning that we're looking forwards in rural communities, there may be some solutions, different solutions in big cities. Some of the health plans may have an ability to reach a lot of their members and other areas where it's much more smaller, private health systems that are there, the public health system may really need to be stepping in especially with those community vaccinators. So I think we're at a point where we really want to understand how to reach people who want to be vaccinated and need to be vaccinated and make it as easy as possible for people to have access to a vaccine. Of course, this is assuming that a safe and effective vaccine is developed and available and that recommendations for its use are issued.

Joe Quimby:
Thank you very much, Dr. Schuchat, ladies and gentlemen, thank you very much for joining from around the world. This now concludes our media availability.

Operator:
This does conclude today's conference. We thank you for your participation. At this time, you may disconnect your line.

END
####
-
CDC Press Briefing Transcripts June 26, 2009
Blogged with the Flock Browser

USA. CDC - Influenza (Flu) - Weekly Report: Influenza Summary Update Week 24, 2008-2009 Season (June 26, 2009, edited)

2008-2009 Influenza Season Week 24 ending June 20, 2009


All data are preliminary and may change as more reports are received.

On June 11, the World Health Organization raised the pandemic alert level from Phase 5 to Phase 6 indicating that an influenza pandemic is underway. The novel influenza A (H1N1) virus now will be referred to as “pandemic H1N1 influenza virus.”


Synopsis:

During week 24 (June 14-20, 2009), influenza activity decreased in the United States, however, there were still higher levels of influenza-like illness than is normal for this time of year.
  • Three thousand two hundred eighty-six (41.9%) specimens tested by U.S. World Health Organization (WHO) and National Respiratory and Enteric Virus Surveillance System (NREVSS) collaborating laboratories and reported to CDC/Influenza Division were positive for influenza.
  • Over 99% of all subtyped influenza A viruses being reported to CDC were pandemic influenza A (H1N1) viruses.
  • The proportion of deaths attributed to pneumonia and influenza (P&I) was below the epidemic threshold.
  • Five influenza-associated pediatric deaths were reported and four of the five deaths were associated with pandemic influenza A (H1N1) virus infection.
  • The proportion of outpatient visits for influenza-like illness (ILI) was below the national baseline. Two of the 10 surveillance regions reported ILI above their region-specific baseline.
  • Twelve states reported geographically widespread influenza activity, seven states reported regional influenza activity, the District of Columbia and 11 states reported local influenza activity, and Puerto Rico and 20 states reported sporadic influenza activity.

National and Regional Summary of Select Surveillance Components

[HHS Surveillance Regions* - Data for current week: Out-patient ILI† - % positive for flu‡ - Number of jurisdictions reporting regional or widespread activity§ / Data cumulative for the season: A (H1) - A (H3) - Pandemic A (H1N1) - A (unable to sub-type)¥ - A(subtyping not performed) - B - Pediatric Deaths]
  • Nation - Normal - 41.9 % - 19 of 52 - 7,839 - 2,208 - 15,954 - 647 - 14,319 - 10,514 - 76
  • Region I - Elevated - 37.0 % - 4 of 6 - 521 - 151 - 1,616 - 13 - 1,479 - 800 - 2
  • Region II - Elevated - 42.8 % - 2 of 3 - 277 - 139 - 774 - 20 - 1,873 - 711 - 9
  • Region III - Normal - 52.4 % - 5 of 6 - 1,300 - 216 - 2,397 - 0 - 709 - 1,360 - 9
  • Region IV - Normal - 27.5 % - 1 of 8 - 829 - 119 - 520 - 44 - 2,051 - 1,216 - 6
  • Region V - Normal - 54.0 % - 2 of 6 - 1,644 - 192 - 6,946 - 150 - 798 - 1,409 - 14
  • Region VI - Normal - 13.7 % - 0 of 5 - 771 - 163 - 936 - 5 - 4,108 - 2,598 - 14
  • Region VII - Normal - 11.2 % - 0 of 4 - 518 - 71 - 277 - 138 - 472 - 532 - 0
  • Region VIII - Normal - 26.5 % - 2 of 6 - 530 - 216 - 895 - 57 - 1,528 - 499 - 6
  • Region IX - Normal - 16.2 % - 3 of 4 - 1,061 - 630 - 785 - 28 - 860 - 699 - 15
  • Region X - Normal - 22.1 % - 0 of 4 - 388 - 311 - 808 - 192 - 441 - 690 -1
(*) HHS regions (Region I: CT, ME, MA, NH, RI, VT; Region II: NJ, NY, Puerto Rico, US Virgin Islands; Region III: DE, DC, MD, PA, VA, WV; Region IV: AL, FL, GA, KY, MS, NC, SC, TN; Region V: IL, IN, MI, MN, OH, WI; Region VI: AR, LA, NM, OK, TX; Region VII: IA, KS, MO, NE; Region VIII: CO, MT, ND, SD, UT, WY; Region IX: AZ, CA, Guam, HI, NV; and Region X: AK, ID, OR, WA)
(†) Elevated means the % of visits for ILI is at or above the national or region-specific baseline
(‡) National data are for current week; regional data are for the most recent three weeks
(§) Includes all 50 states, the District of Columbia, and Puerto Rico
(¥) The majority of influenza A viruses that cannot be sub-typed as seasonal influenza viruses are pandemic A (H1N1) influenza viruses upon further testing


U.S. Virologic Surveillance:

WHO and NREVSS collaborating laboratories located in all 50 states and Washington D.C. report to CDC the number of respiratory specimens tested for influenza.

During the 2008-09 season, influenza A (H1), A (H3), and B viruses have co-circulated in the United States. On April 15 and 17, 2009, CDC confirmed the first two cases of pandemic influenza A (H1N1) virus in the United States. As of June 26, 2009, 27,717 confirmed and probable infections with pandemic influenza A (H1N1) virus and 127 deaths (33 deaths in individuals less than 25 years, 89 deaths in adults 25 years of age older, and five deaths with unknown age) have been identified by CDC and state and local public health departments. Reporting of pandemic influenza A (H1N1) viruses by U.S. WHO collaborating laboratories began during week 17 (week ending May 2, 2009). The results of tests performed during the current week are summarized in the table below.

[Week 24]
  • No. of specimens tested: 7,844
  • No. of positive specimens - (%): 3,286 - (41.9%)
  • Positive specimens by type/subtype Influenza:
    • A: 3,278 - (99.8%)
    • A (pandemic H1N1): 2,452 - (74.8%)
    • A (subtyping not performed): 765 - (23.3%)
    • A (unable to subtype): 38 - (1.2%)
    • A (H3): 6 - (0.2%)
    • A (H1): 17 - (0.5%)
    • Influenza B: 8 - (0.2%)

During week 24, seasonal influenza A (H1), A (H3), and B viruses co-circulated at low levels with pandemic influenza A (H1N1) viruses. Over 99% of all subtyped influenza A viruses being reported to CDC this week were pandemic influenza A (H1N1) viruses.

The increase in the percentage of specimens testing positive for influenza by WHO and NREVSS collaborating laboratories may be due in part to changes in testing practices by health care providers, triaging of specimens by public health laboratories, an increase in the number of specimens collected from outbreaks, and other factors.

(...)


Antigenic Characterization:

CDC has antigenically characterized 1,635 seasonal human influenza viruses [947 influenza A (H1), 171 influenza A (H3) and 517 influenza B viruses] collected by U.S. laboratories since October 1, 2008, and 144 pandemic influenza A (H1N1) viruses.

All 947 influenza seasonal A (H1) viruses are related to the influenza A (H1N1) component of the 2008-09 influenza vaccine (A/Brisbane/59/2007). All 171 influenza A (H3N2) viruses are related to the A (H3N2) vaccine component (A/Brisbane/10/2007).

All 144 pandemic influenza A (H1N1) viruses are related to the A/California/07/2009 (H1N1) reference virus selected by WHO as a potential candidate for pandemic influenza A (H1N1) vaccine.

Influenza B viruses currently circulating can be divided into two distinct lineages represented by the B/Yamagata/16/88 and B/Victoria/02/87 viruses. Sixty-five influenza B viruses tested belong to the B/Yamagata lineage and are related to the vaccine strain (B/Florida/04/2006). The remaining 452 viruses belong to the B/Victoria lineage and are not related to the vaccine strain.

Data on antigenic characterization should be interpreted with caution given that antigenic characterization data is based on hemagglutination inhibition (HI) testing using a panel of reference ferret antisera and results may not correlate with clinical protection against circulating viruses provided by influenza vaccination.

Annual influenza vaccination is expected to provide the best protection against those virus strains that are related to the vaccine strains, but limited to no protection may be expected when the vaccine and circulating virus strains are so different as to be from different lineages, as is seen with the two lineages of influenza B viruses. Antigenic characterization of pandemic influenza A (H1N1) viruses indicates that these viruses are antigenically and genetically unrelated to seasonal influenza A (H1N1) viruses, suggesting that little to no protection would be expected from vaccination with seasonal influenza vaccine.


Antiviral Resistance:

Since October 1, 2008, 1,010 seasonal influenza A (H1N1), 183 influenza A (H3N2), and 550 influenza B viruses have been tested for resistance to the neuraminidase inhibitors (oseltamivir and zanamivir). One thousand twelve seasonal influenza A (H1N1) and 187 influenza A (H3N2) viruses have been tested for resistance to the adamantanes (amantadine and rimantadine). One hundred ninety-one pandemic influenza A (H1N1) viruses have been tested for resistance to the neuraminidase inhibitors (oseltamivir and zanamivir). One hundred seventy-seven pandemic influenza A (H1N1) viruses have been tested for resistance to the adamantanes (amantadine and rimantadine). The results of antiviral resistance testing performed on these viruses are summarized in the table below.

[Isolates tested (n) - Resistant Viruses, Number (%): Oseltamivir / Zanamivir - Isolates tested (n) - Resistant Viruses, Number (%): Adamantanes]
  • Seasonal Influenza A (H1N1) - 1,010 - 1,005 - (99.5%) / 0 - (0) - 1,012 - 6 - (0.6%)
  • Influenza A (H3N2) - 183 - 0 - (0) / 0 - (0) - 187 - 187 - (100%)
  • Influenza B 550 - 0 - (0) / 0 - (0) - N/A* - N/A*
  • Pandemic Influenza A (H1N1) 191 - 0 - (0) / 0 - (0) - 177 - 177 - (100%)
(*) The adamantanes (amantadine and rimantadine) are not effective against influenza B viruses.

The pandemic influenza A (H1N1) virus is susceptible to both neuraminidase inhibitor antiviral medications zanamivir and oseltamivir. It is resistant to the adamantane antiviral medications, amantadine and rimantadine. Antiviral treatment with either oseltamivir or zanamivir is recommended for all patients with confirmed, probable or suspected cases of pandemic influenza A (H1N1) virus infection who are hospitalized or who are at higher risk for seasonal influenza complications. Additional information on antiviral recommendations for treatment and chemoprophylaxis of pandemic influenza A (H1N1) infection is available at http://www.cdc.gov/h1n1flu/recommendations.htm

Three seasonal influenza A (H1N1) viruses collected between February 8 and May 11, 2009 were found to be resistant to both oseltamivir and the adamantanes (amantadine and rimantadine). All influenza A (H1N1) viruses tested retain their sensitivity to zanamivir. The three dually resistant viruses represent less than 0.5% of all seasonal influenza A (H1N1) viruses tested during the 2008-09 influenza season, and as a result, no changes to the influenza antiviral treatment or prophylaxis recommendations will be made at this time. CDC will continue to monitor trends in antiviral resistance over the summer and throughout the upcoming 2009-10 influenza season.


Pneumonia and Influenza (P&I) Mortality Surveillance

During week 24, 6.7% of all deaths reported through the 122-Cities Mortality Reporting System were due to P&I. This percentage is below the epidemic threshold of 6.8% for week 24.

(...)


Influenza-Associated Pediatric Mortality

Five influenza-associated pediatric deaths were reported to CDC during week 24 (California, Connecticut, Indiana, Minnesota, and Wisconsin). Four of these deaths were associated with pandemic influenza A (H1N1) virus infection and one death was due to influenza A (subtyping not performed) virus. The deaths reported this week occurred during weeks 19-24 (the weeks ending May 10-June 20, 2009). Since September 28, 2008, CDC has received 76 reports of influenza-associated pediatric deaths that occurred during the current influenza season, 10 of which were due to pandemic influenza A (H1N1) virus infections.

Of the 37 children who had specimens collected for bacterial culture from normally sterile sites, 15 (40.5%) were positive; Staphylococcus aureus was identified in nine (60.0%) of the 15 children. Four of the S. aureus isolates were sensitive to methicillin and five were methicillin resistant. Thirteen (86.7%) of the 15 children with bacterial coinfections were five years of age or older and 10 (66.7%) of the 15 children were 12 years of age or older. Five of the 10 children with confirmed pandemic influenza A (H1N1) infection had a specimen collected from a normally sterile site; one of the five children had a positive bacterial culture. An increase in the number of influenza-associated pediatric deaths with bacterial coinfections was first recognized during the 2006-07 influenza season. In January 2008, interim testing and reporting recommendations were released regarding influenza and bacterial coinfections in children and are available at (http://www2a.cdc.gov/HAN/ArchiveSys/ViewMsgV.asp?AlertNum=00268).

(...)


Influenza-Associated Hospitalizations

Laboratory-confirmed influenza-associated hospitalizations are monitored in two population-based surveillance networks: the New Vaccine Surveillance Network (NVSN) and the Emerging Infections Program (EIP).

During October 12, 2008 to June 13, 2009, the preliminary laboratory-confirmed influenza-associated hospitalization rate for children 0-4 years old in the NVSN was 4.2 per 10,000. Because of case identification methods utilized in this study, there is a delay from the date of hospitalization to the date of report.

(...)

During April 15, 2009 to June 20, 2009, the following preliminary laboratory-confirmed overall influenza associated hospitalization rates were reported by the EIP (rates include type A, type B, and confirmed Pandemic H1N1):

[Rates for children aged 0-23 months, 2-4 years, and 5-17 years were 1.1, 0.3, and 0.3 per 10,000, respectively. Rates for adults aged 18-49 years, 50-64 years, and >= 65 years were 0.1, 0.1, and 0.2 per 10,000, respectively.


Influenza-Associated Pediatric Mortality*

This value represents an age group-specific average influenza rate from October 1 to April 30 from the 2005-06, 2006-07, and 2007-08 influenza seasons.
**Note: The scales for the 0-23 month and the >= 65 years age groups differ from other age groups.

(...)


Outpatient Illness Surveillance:


Nationwide during week 24, 1.9% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is below the national baseline of 2.4%. (...)

On a regional level, the percentage of outpatient visits for ILI ranged from 0.3% to 5.3%. Two of the 10 surveillance regions reported an ILI percentage above their region specific baseline (Regions I and II). ILI increased during week 24 in six of 10 regions compared to week 23.


Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists:

The influenza activity reported by state and territorial epidemiologists indicates geographic spread of both seasonal influenza and pandemic influenza A (H1N1) viruses and does not measure the severity of influenza activity.

During week 24, the following influenza activity was reported:
  • Widespread influenza activity was reported by 12 states (Arizona, California, Connecticut, Delaware, Hawaii, Maine, New Jersey, New York, Pennsylvania, Rhode Island, Utah, and Virginia).
  • Regional influenza activity was reported by seven states (Colorado, Georgia, Illinois, Maryland, Massachusetts, Minnesota, and West Virginia).
  • Local influenza activity was reported by the District of Columbia and 11 states (Alabama, Florida, Michigan, North Carolina, Oklahoma, Oregon, South Carolina, Tennessee, Texas, Wisconsin, and Wyoming).
  • Sporadic activity was reported by Puerto Rico and 20 states (Alaska, Arkansas, Idaho, Indiana, Iowa, Kansas, Kentucky, Louisiana, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Mexico, North Dakota, Ohio, South Dakota, Vermont, and Washington).
(...)
A description of surveillance methods is available at: http://www.cdc.gov/flu/weekly/fluactivity.htm
(...)
-
CDC - Influenza (Flu) | Weekly Report: Influenza Summary Update Week 24, 2008-2009 Season
Blogged with the Flock Browser

Influenza A(H1N1)v infection - Update 26 June 2009, 17:00 hours CEST (ECDC, edited)

ECDC SITUATION REPORT

Influenza A(H1N1)v infection - Update 26 June 2009, 17:00 hours CEST

[Original Full Document: LINK. EDITED.]


Main developments in past 24 hours

  • 1075 new cases were reported in EU and EFTA countries;
  • 62074 new cases were reported from non-EU and EFTA countries;
  • The total of fatal cases worldwide is 306;
  • Two new countries reported their first cases today: Lithuania (1) and Serbia (2)
  • 48 new fatal cases have been reported by the USA (40), Guatemala (1) Argentina (6) and Australia (1) since yesterday.

This report is based on official information provided by the national public health websites, or through other official communication channels. An update on the number of confirmed cases as of 26 June, 17:00 hours CEST, is presented in Table 1 and Table 2.

Disclaimer: the number of confirmed cases reported is based on laboratory test results, except for the US. Depending on the national laboratory testing policies, the actual number of cases by country may therefore be higher.


Epidemiological update

The number of EU and EFTA countries reporting cases is today 29 out of 31.

In the past 24 hours, 1075 cases were confirmed in 16 EU and EFTA countries, with the UK as main reporting country with 996 new cases (Table1).

The cumulative number of cases in the EU and EFTA countries is now 6022, including one death. .

Outside of the EU and EFTA countries, a total of 62 074 cases, including 305 deaths, have been reported, representing an increase of 7816 from yesterday (Table 2).


European Influenza Surveillance Scheme (EISS) weekly report for week 25 published

Low influenza activity was reported in all European countries providing data during week 25. Overall this indicates low circulation of A(H1N1)v and other influenza viruses at community level.

However an increase of the number of A(H1N1)v virus detections from the sentinel networks was observed during week 25 as compared to the previous week.

Of the 399 specimens collected by the sentinel GP networks, 22 were positive for A(H1N1)v of which 15 in England as compared to one out of 194 in week 24.

In addition, 150 specimens from non sentinel sources (i.e. specimens collected for diagnostic purposes in hospitals) were positive for A(H1N1)v virus during week 25.

All new influenza A(H1N1) viruses tested for antiviral resistance so far proved to be susceptible to oseltamivir and zanamivir and resistant to adamantanes.
The EISS report is available here.


WHO Defines Moderate Pandemic and provides guidance on public health measures

When she declared Phase 6 on June 11th the Director of WHO Margaret Chan announced at the same time that she considered the pandemic at present was of moderate severity. There is no consensus definition of what moderate severity, means though there is a discussion of the topic provided by WHO in the Weekly Epidemiological Record of May 29th In a question and answer section on Phase 6 in its web site WHO has not offered a definition by stating that the phrase moderate pandemic reflects the facts that
  • Most people recover from infection without the need for hospitalization or medical care.
  • Overall, national levels of severe illness from influenza A(H1N1) appear similar to levels seen during local seasonal influenza periods, although high levels of disease have occurred in some local areas and institutions.
  • Overall, hospitals and health care systems in most countries have been able to cope with the numbers of people seeking care, although some facilities and systems have been stressed in some localities.
On today’s issue of the Weekly Epidemiological Record WHO provides guidance on surveillance and control measures based on current knowledge, considering the high variability of epidemiological situation among countries.


Table 1: Reported new confirmed cases and cumulative number of influenza A(H1N1)v as of 26 June 2009, 17:00 hours (CEST) in the EU and EFTA countries

[Country - Confirmed cases reported in the last 24h* - Cumulative number of confirmed cases - Deaths among confirmed cases**]
  1. Austria ... - 12 - ...
  2. Belgium 2 - 37 - ...
  3. Bulgaria ... - 7 - ...
  4. Cyprus 8 - 14 - ...
  5. Czech Republic ... - 9 - ...
  6. Denmark 4 - 41 - ...
  7. Estonia 4 - 12 - ...
  8. Finland 1 - 27 - ...
  9. France ... - 191 - ...
  10. Germany 33 - 366 - ...
  11. Greece 4 - 70 - ...
  12. Hungary ... - 8 - ...
  13. Iceland ... - 4 - ...
  14. Ireland 3 - 29 - ...
  15. Italy ... - 102 - ...
  16. Latvia ... - 1
  17. Lithuania 1 - 1
  18. Luxembourg ... - 3 - ...
  19. Netherlands 6 - 118 - ...
  20. Norway 1 - 24 - ...
  21. Poland ... - 13 - ...
  22. Portugal 2 - 9 - ...
  23. Romania 4 - 23 - ...
  24. Slovakia 2 - 9 - ...
  25. Slovenia ... - 3 - ...
  26. Spain ... - 541 - ...
  27. Sweden 4 - 65 - ...
  28. Switzerland ... - 33 - ...
  29. United Kingdom 996 - 4250 - 1
  • Total 1075 - 6022 - 1
  • Note: cases reported in the EU and EFTA countries correspond to the EWRS notifications by Member States or Ministry of Health websites.
  • (*) Cases reported between 23 June 17:00 hours and 24 June 17:00 hours
  • (**) Deaths are included in the cumulative number of confirmed cases

Table 2: Reported cumulative number of confirmed cases and deaths of influenza A(H1N1)v as of 26 June 2009, 17:00 hours (CEST) outside of the EU and EFTA area

[Country - Confirmed cases reported in the last 24h(a) - Cumulative number of confirmed cases - Deaths among confirmed cases*]
  • EASTERN EUROPE AND CENTRAL ASIA
  1. Montenegro ... - 1 - ...
  2. Serbia 2 - 2
  3. Russian Federation ... - 3 - ...
  4. Ukraine ... - 1 - ...
  • MEDITERRANEAN AND MIDDLE-EAST
  1. Algeria ... - 2 - ...
  2. Bahrain ... - 15 - ...
  3. Egypt ... - 43 - ...
  4. Iran ... - 1 - ...
  5. Iraq ... - 7 - ...
  6. Israel ... - 375 - ...
  7. Jordan ... - 15 - ...
  8. Kuwait ... - 26 - ...
  9. Lebanon ... - 25 - ...
  10. Morocco ... - 9 - ...
  11. Occupied Palestinian Territory ... - 9 - ...
  12. Oman ... - 3 - ...
  13. Qatar ... - 10 - ...
  14. Saudi Arabia ... - 48 - ...
  15. Tunisia ... - 2
  16. Turkey ... - 26 - ...
  17. United Arab Emirates 5 - 7 - ...
  18. Yemen ... - 6 - ...
  • AFRICA
  1. Cape Verde ... - 3 - ...
  2. Ethiopia ... - 2
  3. Ivory Coast ... - 2
  4. South Africa ... - 1 - ...
  • NORTH AMERICA
  1. Canada ... - 6732 - 19
  2. Mexico ... - 8617 - 116
  3. **USA 6268 - 27717 - 127
  • CENTRAL AMERICA AND CARIBBEAN
  1. Antigua and Barbuda ... - 2
  2. Bahamas ... - 4
  3. Barbados 5 - 10 - ...
  4. Bermuda ... - 2 - ...
  5. British Virgin Islands ... - 1 - ...
  6. Cayman Islands ... - 7 - ...
  7. Costa Rica ... - 222 - 1
  8. Cuba ... - 34 - ...
  9. Dominica ... - 1 - ...
  10. Dominican Republic ... - 108 - 2
  11. El Salvador 66 - 226 - ...
  12. Guatemala 19 - 254 - 2
  13. Honduras ... - 119 - 1
  14. Jamaica ... - 19 - ...
  15. ***Martinique ... - 2 - ...
  16. ****Netherlands Antilles ... - 4 - ...
  17. Nicaragua 45 - 265 - ...
  18. Panama ... - 358 - ...
  19. Suriname ... - 11 - ...
  20. Trinidad-Tobago ... - 25 - ...
  • SOUTH AMERICA
  1. Argentina 194 - 1488 - 23
  2. Bolivia ... - 47 - ...
  3. Brazil ... - 399 - ...
  4. Chile ... - 5186 - 7
  5. Colombia ... - 73 - 2
  6. Ecuador 10 - 125 - ...
  7. Paraguay 13 - 79 - ...
  8. Peru 61 - 360 - ...
  9. Uruguay ... - 195 - ...
  10. Venezuela 19 - 153 - ...
  • NORTH-EAST AND SOUTH ASIA
  1. Bangladesh 6 - 7 - ...
  2. China 42 - 570 - ...
  3. Hong Kong SAR 62 - 506 - ...
  4. India 23 - 73 - ...
  5. Japan 48 - 1048 - ...
  6. Korea (South) 27 - 142 - ...
  7. Macao 1 - 13 - ...
  8. Sri Lanka 2 - 7 - ...
  9. Taiwan ... - 61 - ...
  • SOUTH-EAST ASIA
  1. Brunei Darussalam ... - 11 - ...
  2. Cambodia 4 - 5
  3. Indonesia 1 - 2
  4. Laos PDR ... - 3
  5. Malaysia ... - 68 - ...
  6. Philippines ... - 727 - 1
  7. Singapore 121 - 315 - ...
  8. Thailand 211 - 985 - ...
  9. Vietnam 5 - 63 - ...
  • AUSTRALIA AND PACIFIC
  1. *****Australia 519 - 3519 - 4
  2. Fiji ... - 2
  3. ***French Polynesia ... - 1 - ...
  4. New Zealand 37 - 453 - ...
  5. Papua New Guinea ... - 1 - ...
  6. Samoa ... - 1 - ...
  7. Vanuatu ... - 2
  • TOTAL 7816 - 62074 - 305
  • Note: cases reported in non-EU and EFTA countries correspond to cases published on Ministry of Health websites, or through WHO, or through credible media source quoting national authorities. Therefore, some of these cases may be taken out at a later stage if not validated.
  • (a) Cases reported between 23 June 17:00 hours and 24 June 17:00 hours
  • (*) Deaths are included in the cumulative number of confirmed cases
  • (**) Cases in the US include both probable and confirmed cases. They also include confirmed cases from Puerto Rico.
  • (***) The cases in Martinique and French Polynesia were reported by France
  • (****) Three of the cases are reported to occur in a cruise ship in Curacao.
  • (*****) One Australian case reported from a cruise ship.
(...)

-
------
Blogged with the Flock Browser

EISS - Bulletin Review: Influenza A(H1N1)v detections across the European region continue but influenza activity in the community remains at baseline levels (June 26, 2009, edited)

EISS - Weekly Electronic Bulletin Week 25 : 15/06/2009-21/06/2009 - 26 June 2009, Issue N° 311

Influenza A(H1N1)v detections across the European region continue but influenza activity in the community remains at baseline levels


The 2008-2009 influenza season is over and was described in the Weekly Electronic Bulletin of week 22/2009. As of week 24/2009, bulletins present developments regarding the pandemic (H1N1) 2009 in the European region since week 16/2009.


Summary:

In week 25/2009, all countries reporting in the European region indicated low levels of influenza activity and 172 detections of influenza A(H1)v. Although a considerable number of influenza detections were reported, mainly due to pandemic (H1N1) 2009, influenza activity remains at or below baseline levels in Europe. The influenza A(H1)v was the dominant type reported in Belgium, Denmark, Hungary, Ireland, Italy, the Netherlands, Northern Ireland, Norway and Turkey.


Epidemiological situation - week 25/2009:

For the intensity indicator, the national network levels of influenza-like illness (ILI) and/or acute respiratory infection (ARI) were low in all countries that reported this indicator. For the geographical spread indicator, all countries reported sporadic or no activity. Definitions for the epidemiological indicators can be found here.


Cumulative epidemiological situation - weeks 16-25/2009:

Seasonal influenza activity was over in almost all countries in the European region by week 16/2009 and the intensity of activity had returned to levels typically seen outside the winter season. To date, the occurrence of A(H1N1)v infection since week 16/2009 has not given rise to increased levels of ILI or ARI, although in England a slight increase can be observed in week 25/2009, see here.


Virological situation - week 25/2009:

The total number of respiratory specimens collected by sentinel physicians in week 25/2009 was 399 of which 33 (8.3%) were positive for influenza virus: 32 type A (22 H1v, two subtype H3, and eight A unsubtyped) and one type B. In addition, 286 non-sentinel source specimens (e.g. specimens collected for diagnostic purposes in hospitals) were reported positive for influenza virus: 266 type A (150 subtype H1v, 28 subtype H3, 10 subtype H1, 78 not subtyped) and 20 type B.


Cumulative virological situation - weeks 16/2009-25/2009:

Of 1993 virus detections
(sentinel and non-sentinel) since week 16/2009, 1517 (76%) were type A (713 subtype H1v, 268 subtype H3, 111 subtype H1 and 425 not subtyped) and 476 (24%) were type B. The increase in detections of the influenza A(H1)v virus over the last weeks can be found (click here).

Based on the antigenic and/or genetic characterisation of 3266 influenza viruses reported from week 20/2009 to week 25/2009, 2139 (65%) were reported as A/Brisbane/10/2007 (H3N2)-like, 151 (5%) as A/Brisbane/59/2007 (H1N1)-like, 30 (1%) as B/Florida/4/2006-like (B/Yamagata/16/88 lineage), 921 (28%) as B/Malaysia/2506/2004-like (B/Victoria/2/87 lineage) and 25 (1%) as A/California/4/2009 (H1N1)v-like (click here), the current virus strain recommended by WHO for vaccine preparation (click here).

All A(H1N1)v viruses tested have been sensitive to oseltamivir and zanamivir but resistant to M2 inhibitors.


Comment:


In week 25/2009, 172 detections of the influenza A(H1)v were reported, similar to the previous week. However, the numbers do not reflect the total number of confirmed cases in the European Region reported on a daily basis during week 25/2009 (see below) to WHO through the IHR National Focal Points (click here) and to ECDC through the Early Warning Response System (click here) and efforts to harmonize this reporting are underway. Virus detections outside the winter season are usually highly sporadic in Europe, so these detections are unusual for this time of the year. However, influenza activity in the community remains low across all countries in the European region.

As of 19 June 2009, there have been a total of 4888 laboratory confirmed cases and one death due to pandemic (H1N1) 2009 reported in the European region: 4482 in 26 EU/EEA countries (including one death) and 406 in five non-EU/EEA countries. For a detailed epidemiological description of the A(H1N1)v detections in the European region (April–May 2009), click here, and in the EU/EFTA countries (April-8 June 2009), click here.

Worldwide, over 55000 cases of A(H1N1)v infection have been reported and on 11 June 2009 the WHO raised the pandemic alert level to phase 6 (click here). For more information, please go to the dedicated web pages of ECDC (click here) or WHO (click here). European countries have been requested to continue to report both clinical and virological data on influenza until further notice.


Background:

The Weekly Electronic Bulletin presents and comments on influenza activity in the 53 countries that report to EISS. Of these countries, 29 reported both clinical and virological data, two reported virological data only and four reported clinical data only in week 25/2009. The spread of influenza viruses and their epidemiological impact in Europe are being monitored by the network under the aegis of the European Centre for Disease Prevention and Control in Stockholm (Sweden) and the WHO Regional Office for Europe in Copenhagen (Denmark), in collaboration with the WHO Collaborating Centre for Reference and Research on Influenza in London (UK).


Other bulletins:

The EISS bulletin is prepared using reports from GP consultations and other sources, depending on individual country arrangements. It is important to recognise that different health care systems and types of measurement should also be considered when assessing the impact of influenza. To view national/regional bulletins in Europe and other bulletins from around the world, please click here.

(...)
-
EISS - Bulletin Review
Blogged with the Flock Browser

Highly pathogenic avian influenza, Vietnam (WAHID Interface - OIE World Animal Health Information Database, June 26, 2009, edited)

Highly pathogenic avian influenza, Vietnam

Information received on 26/06/2009 from Mr Bui Quang Anh, Chief Veterinary Officer, Department of Animal Health, Ministry of Agriculture and Rural Development, HANOI, Vietnam

-- Summary
Report type Follow-up report No. 32
Start date 07/12/2006
Date of first confirmation of the event 19/12/2006
Report date 26/06/2009
Date submitted to OIE 26/06/2009
Reason for notification Reoccurrence of a listed disease
Date of previous occurrence 10/08/2006
Manifestation of disease Clinical disease
Causal agent Highly pathogenic avian influenza virus Serotype H5N1
Nature of diagnosis Clinical, Laboratory (basic), Laboratory (advanced)
This event pertains to a defined zone within the country
Related reports * Immediate notification (19/12/2006)
* Follow-up report No. 1 (04/01/2007)
* Follow-up report No. 2 (17/01/2007)
* Follow-up report No. 3 (27/02/2007)
* Follow-up report No. 4 (23/03/2007)
* Follow-up report No. 5 (02/04/2007)
* Follow-up report No. 6 (17/05/2007)
* Follow-up report No. 7 (24/05/2007)
* Follow-up report No. 8 (07/06/2007)
* Follow-up report No. 9 (05/07/2007)
* Follow-up report No. 10 (14/09/2007)
* Follow-up report No. 11 (11/10/2007)
* Follow-up report No. 12 (31/10/2007)
* Follow-up report No. 13 (12/11/2007)
* Follow-up report No. 14 (07/01/2008)
* Follow-up report No. 15 (01/02/2008)
* Follow-up report No. 16 (23/02/2008)
* Follow-up report No. 17 (12/03/2008)
* Follow-up report No. 18 (01/04/2008)
* Follow-up report No. 19 (23/04/2008)
* Follow-up report No. 20 (14/07/2008)
* Follow-up report No. 21 (30/09/2008)
* Follow-up report No. 22 (27/11/2008)
* Follow-up report No. 23 (30/12/2008)
* Follow-up report No. 24 (07/01/2009)
* Follow-up report No. 25 (03/02/2009)
* Follow-up report No. 26 (06/02/2009)
* Follow-up report No. 27 (16/02/2009)
* Follow-up report No. 28 (22/02/2009)
* Follow-up report No. 29 (06/03/2009)
* Follow-up report No. 30 (10/04/2009)
* Follow-up report No. 31 (21/05/2009)
* Follow-up report No. 32 (26/06/2009)

-- New outbreaks

- Outbreak 1 - Lien Hoa, Yen Hoa, Yen Hung, QUANG NINH
Date of start of the outbreak 18/06/2009
Outbreak status Continuing (or date resolved not provided)
Epidemiological unit Village
Affected animals: Species - Susceptible - Cases - Deaths - Destroyed - Slaughtered
- Birds - 1830 - 650 - 504 - 1326 - 0
Affected population Birds including chickens, ducks and muscovy ducks of four small household farms were found dead.

Summary of outbreaks: Total outbreaks: 1
Outbreak statistics: Species - Apparent morbidity rate - Apparent mortality rate - Apparent case fatality rate - Proportion susceptible animals lost*
- Birds - 35.52% - 27.54% - 77.54% - 100.00%
* Removed from the susceptible population through death, destruction and/or slaughter

-- Epidemiology
Source of the outbreak(s) or origin of infection
* Introduction of new live animals
* Illegal movement of animals
* Fomites (humans, vehicles, feed, etc.)

-- Control measures
Measures applied
* Quarantine
* Movement control inside the country
* Disinfection of infected premises/establishment(s)
* Modified stamping out
* No vaccination
* No treatment of affected animals
Measures to be applied
* Screening
* Zoning
* Vaccination in response to the outbreak (s)

-- Diagnostic test results
Laboratory name and type Regional Animal Health Office No. 2 (National laboratory)
Tests and results: Species - Test - Test date - Result
- Birds - real-time reverse transcriptase/polymerase chain reaction (RRT-PCR) - 18/06/2009 - Positive

-- Future Reporting
The event is continuing. Weekly follow-up reports will be submitted.
-
WAHID Interface - OIE World Animal Health Information Database
Blogged with the Flock Browser

India. Update on influenza a H1N1 as on 26th June 2009 19:8 IST (PIB Press Release, edited)

Update on influenza a H1N1 as on 26th June 2009 19:8 IST


World Health Organization has reported 55867 laboratory confirmed cases of influenza A/H1N1 infection from 108 countries as on 24th June 2009. There have been 238 deaths. No further update is available.


Health screening of passengers coming from affected countries is continuing in 22 International airports.

51,140 passengers have been screened on 25.6.2009 of which 29,550 passengers were from affected countries.

224 doctors and 112 paramedics are manning 77 counters at these airports.

A cumulative total of 2,428,173 passengers have been screened.

Two new cases have been reported today one each from Delhi and Mumbai.

The case from Mumbai is a 15 year old female who traveled from USA reached Delhi on 22.6.2009 and traveled to Mumbai by Train on 23.6.2009. She had complaints of fever, cough and running nose and reported to identified health facility at Mumbai on 25.6.2009.

The case from Delhi is a 18 year old female and a contact of earlier positive case. She had fever, cough, sore throat and nasal catarrh and admitted in the identified health facility in Delhi on 25.6.2009.

The indigenous positive case [66 year old female] at Delhi, covered in earlier reports, is stable.

629 persons have been tested so far of which 80 are positive for Influenza A H1N1 [Swine].

Of these, seven are indigenous cases, who got the infection from the positive cases who traveled from abroad. The rest of the samples have been found negative for the novel virus.

176 out of the 629 persons have been identified through entry screening, twenty one through contact tracing and the rest were self reported.

Of the 80 cases, 56 have been discharged. Rest of them remain admitted to the identified health facility.

The situation is being monitored.

AD/VN
-
PIB Press Release
Blogged with the Flock Browser

Australia. National tally of confirmed cases of H1N1 Influenza 09 - As at 5pm, 26 June 2009 (Dept. of Health, edited)

Australian Government - Department of Health and Ageing

National tally of confirmed cases of H1N1 Influenza 09 - As at 5pm, 26 June 2009

[Original Document: LINK. EDITED.]


The information contained in this situation report uses the most accurate currently available data.

Given the rapidly changing nature of the incident, recipients should be aware of the potential for later confirmation or clarification.


Current Australian confirmed cases of, and deaths associated with, H1N1 Influenza 09 (1700 AEST on 26 June 2009)

[Jurisdiction - Confirmed Cases - Deaths]

  • Tasmania 71 - 0
  • Northern Territory 125 - 0
  • Australian Capital Territory 131 - 0
  • Western Australia 190 - 0
  • South Australia 262 - 1
  • Queensland 527 - 0
  • New South Wales 653 - 0
  • Victoria 1560 - 3
  • Total 3519 - 4
-
------
Blogged with the Flock Browser

UK. HPA - Update on swine flu cases (June 26, 2009, edited)

Update on swine flu cases - 26 June 2009


535 further patients under investigation in England have today been confirmed through laboratory testing with swine flu. Together with the 111 laboratory confirmed cases in Scotland reported yesterday (June 25 2009) by the Scottish Government, five laboratory confirmed cases in Northern Ireland announced yesterday by the Northern Ireland Executive and three laboratory confirmed cases in Wales announced earlier today by the National Public Health Service for Wales and the Welsh Assembly Government, this brings the total number of laboratory confirmed UK cases identified since April 2009 to 4,250.
[Region where sample was tested (1) - Laboratory confirmed new cases for June 26 2009 - Cumulative laboratory confirmed cases as at June 26 2009]
  • East of England 47 - 205
  • East Midlands 14 - 63
  • London 225 - 985
  • North East 4 - 34 (2)
  • North West 5 - 55
  • South East 51 - 323
  • South West 14 - 88
  • West Midlands 158 - 1516
  • Yorkshire & Humber 17 - 95
  • TOTAL ENGLAND 535 - 3364 (3)
  • Northern Ireland ... - 24
  • Scotland ... - 850
  • Wales 3 - 12
  • TOTAL UK 538 - 4250
  • (1) Current testing arrangements mean that the regional breakdown of figures reflects the regional laboratory where samples are tested which may not always be in the region where the patient lives (as a result there may be some small variations in regional figures as cases are reassigned to their home regions).
  • (2) One case previously reported in the North East has been removed.
  • (3) England has also reported a cumulative today of 442 clinically presumed cases.
  • NB: A number of clinically presumed cases will ultimately be laboratory confirmed following sample testing, and therefore there may be some duplication within the laboratory confirmed and clinically presumed numbers. It has been agreed in Scotland not to use "clinical diagnosis" as a category for counting cases any more. Hence Scotland will not be producing any data in this category in future.
Ends


Notes to editors

General infection control practices and good respiratory hand hygiene can help to reduce transmission of all viruses, including swine flu. This includes:
  • Maintaining good basic hygiene, for example washing hands frequently with soap and water to reduce the spread of virus from your hands to face or to other people.
  • Cleaning hard surfaces (e.g. door handles) frequently using a normal cleaning product.
  • Covering your nose and mouth when coughing or sneezing, using a tissue when possible.
  • Disposing of dirty tissues promptly and carefully.
  • Making sure your children follow this advice.

Further information on swine flu is available on the Health Protection Agency's website at www.hpa.org.uk/swineflu.

For media enquiries only please contact the Health Protection Agency's Centre for Infections press office on
020 8327 7080
020 8327 6647
020 8327 7098
020 8327 7097
020 8327 6690

Last reviewed: 26 June 2009
-
HPA - Update on swine flu cases
Blogged with the Flock Browser

New influenza A (H1N1) virus: WHO guidance on public health measures, 11 June 2009 (WHO WER, June 26, 2009, edited)

Weekly epidemiological record - 26 JUNE 2009, 84th YEAR - No. 26, 2009, 84, 261–268 - http://www.who.int/wer

[Original Document: LINK. EDITED.]


New influenza A (H1N1) virus: WHO guidance on public health measures, 11 June 2009



WHO is providing the following guidance to help countries manage the 2009 influenza pandemic. This guidance reflects current knowledge and experience gained since April 2009, when WHO announced the emergence of the new influenza A (H1N1) virus. Further international spread of the pandemic virus is expected to continue over the coming weeks and months. At this time, however, the epidemiological situation among countries is highly variable, with some countries reporting no or few cases and others experiencing widespread community outbreaks. In past pandemics, the greatest impact on health has occurred in the first year, but excess deaths associated with spread of the pandemic virus have occurred over a 2-year period.

General guidance for all countries

Monitoring the pandemic.

Countries should maintain surveillance(1) during the pandemic period by:

  • monitoring the virus for important genetic, antigenic or functional changes (for example, sensitivity to antiviral drugs);
  • monitoring disease and outbreaks to assess whether levels of influenza activity are increasing or decreasing;
  • monitoring the functioning of healthcare systems to ensure continuity of services and rapid adjustments;
  • identifying and investigating unusual cases, clusters or outbreaks, so that important changes in epidemiology or disease severity are identified quickly;
  • characterizing in detail the clinical and epidemiological features of the first >100 cases of pandemic disease in any new settings to ensure that critical information is collected and made available widely;
  • reporting surveillance information to WHO frequently and rapidly.

Communicating information to the public.


Countries should make active communication a part of their strategic response by providing accurate and up-to-date information on issues such as pandemic activity and actions being taken by the government.(2)


Adapting plans and interventions to the 2009 pandemic.

Countries should revise pre-existing national pandemic plans to ensure that national actions taken for the 2009 pandemic are sustainable and appropriate to its current level of severity.(3) Specifically:
  • national efforts should focus primarily on mitigating the impacts on health and society of the virus through appropriate care of ill people rather than on attempts to contain transmission of the disease;
  • health-care systems should be prepared to manage a higher volume of cases and, potentially, more serious cases of illness;
  • countries should implement plans for obtaining essential medicines and equipment, as well as antiviral medicines and vaccines.
In addition to the general guidance provided above, WHO also advises countries to note the following guidance that is specific to their current level of disease transmission and local context.


Guidance for countries with widespread community-level transmission

Surveillance
  • As a baseline, national surveillance should track
    • (i) the spread of, and increases or decreases in, the number of cases, deaths and outbreaks associated with the pandemic virus;
    • (ii) the functioning of the health-care system; and
    • (iii) any changes in the viruses.
  • During the remaining pandemic period, the collection of clinical samples for virus testing should be limited to selected samples of cases only, rather than laboratory-testing of all cases, to save on resources while allowing critical information to be collected.

Control measures
  • The primary focus should be the appropriate management of patients, either at home or in health-care facilities.
  • The health-care system should be protected and supported so that it can continue to operate.
  • Most people with pandemic infection can be diagnosed clinically without the need for laboratory testing.
  • Community-level measures such as school closures and cancellations of mass gatherings should be considered on a case-by-case basis to slow increases in infection and to try and reduce pressure on the health-care system. In implementing such measures, consideration should be given to the disruption they may cause, and the feasibility and sustainability of their implementation.

Guidance for countries with no reported cases of pandemic infection

Surveillance
  • Countries should identify any national disease and virus surveillance capacity that can be used to detect and monitor cases of disease, including laboratories with the capacity to test influenza viruses. If no capacity is available within a country, WHO can help with shipment of clinical specimens to another laboratory.
  • Surveillance should focus on settings such as closed communities (for example, schools, military camps, health institutions) particularly in urban settings, since these are locations where new cases are likely to occur.
  • Baseline surveillance for influenza or severe respiratory illness should be maintained.
  • Entry or exit screening at airports and contact tracing can be considered, but such actions are resourceintensive and will provide decreasing benefi ts as infections become more widespread. Such screening may detect cases but may not prevent the spread of the disease because asymptomatic or sub-clinical infections will not be detected.

Control measures
  • Incoming travellers who are sick should be provided with the information needed to obtain medical attention.
  • The health-care sector should
    • (i) be ready to manage increasing numbers of patients with respiratory disease;
    • (ii) ensure the availability of essential medicines and supplies for the treatment of pneumonia as well as other common life-threatening illnesses in the community; and
    • (iv) provide training to health-care workers on the diagnosis and treatment of influenza patients.(4)
  • WHO does not recommend border closures or travel restrictions because such measures will not prevent the spread of the disease and may have a negative economic impact.

Guidance for countries in transition

Surveillance
  • Countries should notify laboratory-confirmed cases to WHO in accordance with the International Health Regulations (2005).(5)
  • Detailed epidemiological, clinical and virological information should be collected on the fi rst 100 cases, or as many as is possible.
  • Information to assess the severity of the disease at the national level6 should be collected.
  • Highly resource-intensive efforts such as contact tracing should be phased out once the value of the collected information drops.

Control measures
  • Countries in transition should be prepared to move towards implementing the control measures recommended to countries with sustained communitylevel transmission, as described above.
  • Antiviral prophylaxis generally should be limited, and antiviral medicines should be reserved for treating patients, particularly those who have, or are at high risk for, severe disease.

(1) Global surveillance during an influenza pandemic [version 1, updated draft April 2009]. Geneva, World Health Organization, 2009 (available at http://www.who.int/csr/disease/swineflu/global_pandemic_influenza_surveilance_apr09.pdf ; accessed June 2009).
(2) For guidance, see WHO Outbreak communication guidelines. Geneva, World Health Organization, 2005 (WHO/CDS/2005.28; available at http://www.who.int/infectious-disease-news/IDdocs/whocds200528/whocds200528en.pdf ; accessed June 2009).
(3) For further guidance, see Pandemic influenza preparedness and response: a WHO guidance document. Geneva, World Health Organization, 2009 (available at http://www.who.int/csr/disease/influenza/pipguidance2009/en/index.html ; accessed June 2009).
(4) Resources on clinical care are available from the web site of the WHO Department of Epidemic and Pandemic Alert and Response at http://www.who.int/csr/disease/swineflu/guidance/clincal/en/index.html .
(5) International Health Regulations (2005), 2nd edition. Geneva, World Health Organization, 2005 (available at http://whqlibdoc.who.int/publications/2008/9789241580410_eng.pdf ; accessed June 2009).
(6) See No. 22, 2009, pp. 197–202 (available at http://www.who.int/wer/2009/wer8422.pdf ; accessed June 2009).

(...)

-
------
Blogged with the Flock Browser

Low pathogenic avian influenza (poultry), Spain (OIE, June 26, 2009, edited)

Low pathogenic avian influenza (poultry), Spain

Information received on 26/06/2009 from Dr Lucio Ignacio Carbajo Goni , Subdirector General de Sanidad de la Producción Primaria, Dirección General de Recursos Agrícolas y Ganaderos, Ministerio de Medio Ambiente y Medio Rural y Marino, Madrid, Spain

[Original Full Document: LINK. EDITED.]


-- Summary

Report type Immediate notification
Start date 12/06/2009
Date of first confirmation of the event 16/06/2009
Report date 26/06/2009
Date submitted to OIE 26/06/2009
Reason for notification First occurrence of a listed disease
Manifestation of disease Sub-clinical infection
Causal agent Low pathogenic avian influenza virus (H5) Serotype Pending
Nature of diagnosis Laboratory (advanced)
This event pertains to the whole country


-- New outbreaks


Summary of outbreaks: Total outbreaks: 1

- Outbreak Location and Affected population: NAVARRA (Los Arcos) : Ducks

Total animals affected: Species - Susceptible - Cases - Deaths - Destroyed - Slaughtered
* Birds - 3625 - ** - 0 - 0 - 3625

Outbreak statistics: Species - Apparent morbidity rate - Apparent mortality rate - Apparent case fatality rate - Proportion susceptible animals lost*
* Birds - ** - 0.00% - ** - 100.00%

* Removed from the susceptible population through death, destruction and/or slaughter
** Not calculated because of missing information


-- Epidemiology
Source of the outbreak(s) or origin of infection Unknown or inconclusive


-- Epidemiological comments
Avian influenza virus serotype H5 was isolated by PCR; PCR for the N1 neuraminidase was negative. Sequencing confirmed that it was a low pathogenic virus.

Note by the OIE Animal Health Information Department: H5 and H7 avian influenza in its low pathogenic form in poultry is a notifiable disease as per Chapter 10.4. on avian influenza of the Terrestrial Animal Health Code (2008).


-- Control measures
Measures applied Zoning
Disinfection of infected premises/establishment(s)
Modified stamping out
Vaccination prohibited
No treatment of affected animals

Measures to be applied No other measures


-- Diagnostic test results
Laboratory name and type Algete (National laboratory)
Tests and results: Species - Test - Test date - Result
- Birds - real-time PCR - 16/06/2009 - Positive
- Birds - virus sequencing - 16/06/2009 - Positive


-- Future Reporting
The event is continuing. Weekly follow-up reports will be submitted.

-
------

Blogged with the Flock Browser

A/H1N1 influenza, Argentina (OIE, June 25, 2009, edited)

A/H1N1 influenza, Argentina

[Original Full Document: LINK. EDITED.]


Information received on 25/06/2009 from Dr Jorge Nestor Amaya, Presidente, Presidencia, SENASA, BUENOS AIRES, Argentina


-- Summary

Report type Immediate notification
Start date 15/06/2009
Date of first confirmation of the event 24/06/2009
Report date 25/06/2009
Date submitted to OIE 25/06/2009
Reason for notification Emerging disease
Morbidity 30 % Mortality 0 % Zoonotic impact Se está investigando ya que la hipótesis indicaría que el origen fueron contactos humanos enfermos.
Causal agent A/H1N1 influenza virus
Serotype Other
This event pertains to the whole country


-- New outbreaks

Summary of outbreaks: Total outbreaks: 1

- Outbreak Location and Affected population: BUENOS AIRES (San Andrés de Giles, San Andrés de Giles) : A commercial pig farm with biosecurity measures in place and its own restocking system; a 4.5-hectares area. No other animal species in the farm. The distribution of the animals is as follows: 516 sows, 7 hogs, 2,900 castrated pigs, 58 young sows and 2,105 sucking pigs.

Total animals affected: Species - Susceptible - Cases - Deaths - Destroyed - Slaughtered
* Swine - 5586 - 1676 - 0 - 0 - 0

Outbreak statistics : Species - Apparent morbidity rate - Apparent mortality rate - Apparent case fatality rate - Proportion susceptible animals lost*
* Swine - 30.00% - 0.00% - 0.00% - 0.00%

* Removed from the susceptible population through death, destruction and/or slaughter


-- Epidemiology
Source of the outbreak(s) or origin of infection Under investigation

-- Epidemiological comments
Between 7 and 9 June 2009, two workers of the farm showed flu signs, but they did not consult a doctor nor made diagnostic tests.
The farm has its own restocking system. The last entry of animals occurred in July 2008. The farm applies biosecurity measures and the animals only leave the farm for slaughter.
Since 24 June 2009, no clinical signs have been observed in the animals of that establishment.


-- Control measures
Measures applied Quarantine
Disinfection of infected premises/establishment(s)
No vaccination
No treatment of affected animals

Measures to be applied No other measures


-- Diagnostic test results
Laboratory name and type Malbrán Institute (National laboratory)
Tests and results: Species - Test - Test date - Result
* Swine - reverse transcription - polymerase chain reaction (RT-PCR) - 24/06/2009 - Positive


-- Future Reporting
The event is continuing. Weekly follow-up reports will be submitted.

-
------

Blogged with the Flock Browser

Indonesia. Denpasar, Bali ::: Another A/H1N1 confirmed case

Denpasar, Bali (ANTARA News) – Officials announce confirmed case from Bali. Agus Somia – head of A/H1N1 flu control team – said that an Australian, George Colmant (21) tested positive A/H1N1 flu infection. Until Friday (26/6) patient is still under treatment in Sanglah hospital, Denpasar, Bali. Sanglah hospital previously treated another “suspect”, Bobie Masoner (22), who [...]

View Original Article

Blogged with the Flock Browser

WHO | Influenza A(H1N1) - update 54

Influenza A(H1N1) - update 54


Laboratory-confirmed cases of new influenza A(H1N1) as officially reported to WHO by States Parties to the International Health Regulations (2005)

26 June 2009 07:00 GMT

The breakdown of the number of laboratory-confirmed cases is given in the following map and table.
Map of the spread of Influenza A(H1N1): number of laboratory confirmed cases and deaths [png 423kb]


[Country, territory and area - Cumulative total / Newly confirmed since the last reporting period (Cases - Deaths)]
  1. Algeria 2 - 0 / 0 - 0
  2. Antigua and Barbuda 2 - 0 / 0 - 0
  3. Argentina 1391 - 21 / 178 - 14
  4. Australia 3280 - 3 / 423 - 1
  5. Austria 12 - 0 / 0 - 0
  6. Bahamas 4 - 0 / 0 - 0
  7. Bahrain 15 - 0 / 0 - 0
  8. Bangladesh 1 - 0 / 0 - 0
  9. Barbados 10 - 0 / 5 - 0
  10. Belgium 36 - 0 / 6 - 0
  11. Bermuda, UKOT 1 - 0 / 0 - 0
  12. Bolivia 47 - 0 / 3 - 0
  13. Brazil 399 - 0 / 65 - 0
  14. British Virgin Islands, UKOT 1 - 0 / 0 - 0
  15. Brunei Darussalam 11 - 0 / 7 - 0
  16. Bulgaria 7 - 0 / 2 - 0
  17. Cambodia 5 - 0 / 4 - 0
  18. Canada 6732 - 19 / 275 - 4
  19. Cap Verde 3 - 0 / 0 - 0
  20. Cayman Islands, UKOT 9 - 0 / 2 - 0
  21. Chile 5186 - 7 / 871 - 3
  22. China 1089 - 0 / 183 - 0
  23. Colombia 72 - 2 / 1 - 0
  24. Costa Rica 222 - 1 / 33 - 0
  25. Cote d'Ivoire 2 - 0 / 0 - 0
  26. Cuba 34 - 0 / 19 - 0
  27. Cyprus 9 - 0 / 4 - 0
  28. Czech Republic 9 - 0 / 2 - 0
  29. Denmark 41 - 0 / 7 - 0
  30. Dominica 1 - 0 / 0 - 0
  31. Dominican Republic 108 - 2 / 0 - 0
  32. Ecuador 125 - 0 / 10 - 0
  33. Egypt 43 - 0 / 3 - 0
  34. El Salvador 160 - 0 / 0 - 0
  35. Estonia 8 - 0 / 3 - 0
  36. Ethiopia 2 - 0 / 0 - 0
  37. Fiji 2 - 0 / 0 - 0
  38. Finland 26 - 0 / 0 - 0
  39. France 191 - 0 / 20 - 0
  40. French Polynesia, FOC 1 - 0 / 0 - 0
  41. Martinique, FOC 2 - 0 / 0 - 0
  42. Germany 333 - 0 / 32 - 0
  43. Greece 73 - 0 / 15 - 0
  44. Guatemala 254 - 2 / 19 - 1
  45. Honduras 118 - 1 / 0 - 1
  46. Hungary 8 - 0 / 1 - 0
  47. Iceland 4 - 0 / 0 - 0
  48. India 64 - 0 / 0 - 0
  49. Indonesia 2 - 0 / 2 - 0
  50. Iran 1 - 0 / 1 - 0
  51. Ireland 29 - 0 / 6 - 0
  52. Israel 405 - 0 / 30 - 0
  53. Italy 102 - 0 / 6 - 0
  54. Jamaica 19 - 0 / 0 - 0
  55. Japan 1049 - 0 / 156 - 0
  56. Jordan 15 - 0 / 0 - 0
  57. Korea, Republic of 142 - 0 / 27 - 0
  58. Kuwait 30 - 0 / 4 - 0
  59. Laos 3 - 0 / 0 - 0
  60. Latvia 1 - 0 / 0 - 0
  61. Lebanon 25 - 0 / 0 - 0
  62. Luxembourg 3 - 0 / 0 - 0
  63. Malaysia 68 - 0 / 0 - 0
  64. Mexico 8279 - 116 / 432 - 1
  65. Montenegro 1 - 0 / 0 - 0
  66. Morocco 11 - 0 / 2 - 0
  67. Netherlands 116 - 0 / 6 - 0
  68. Netherlands Antilles, Curaçao * 3 - 0 / 0 - 0
  69. Netherlands Antilles, Sint Maarten 1 - 0 / 0 - 0
  70. New Zealand 453 - 0 / 67 - 0
  71. Nicaragua 265 - 0 / 45 - 0
  72. Norway 22 - 0 / 0 - 0
  73. Oman 3 - 0 / 0 - 0
  74. Panama 358 - 0 / 28 - 0
  75. Papua New Guinea 1 - 0 / 0 - 0
  76. Paraguay 79 - 0 / 21 - 0
  77. Peru 252 - 0 / 35 - 0
  78. Philippines 445 - 1 / 0 - 0
  79. Poland 13 - 0 / 0 - 0
  80. Portugal 7 - 0 / 1 - 0
  81. Qatar 10 - 0 / 0 - 0
  82. Romania 19 - 0 / 0 - 0
  83. Russia 3 - 0 / 0 - 0
  84. Samoa 1 - 0 / 0 - 0
  85. Saudi Arabia 48 - 0 / 3 - 0
  86. Serbia 2 - 0 / 2 - 0
  87. Singapore 315 - 0 / 121 - 0
  88. Slovakia 7 - 0 / 3 - 0
  89. Slovenia 3 - 0 / 2 - 0
  90. South Africa 1 - 0 / 0 - 0
  91. Spain 541 - 0 / 2 - 0
  92. Sri Lanka 7 - 0 / 2 - 0
  93. Suriname 11 - 0 / 0 - 0
  94. Sweden 61 - 0 / 6 - 0
  95. Switzerland 47 - 0 / 14 - 0
  96. Thailand 774 - 0 / 0 - 0
  97. Trinidad and Tobago 25 - 0 / 0 - 0
  98. Tunisia 2 - 0 / 0 - 0
  99. Turkey 26 - 0 / 0 - 0
  100. Ukraine 1 - 0 / 0 - 0
  101. United Arab Emirates 7 - 0 / 5 - 0
  102. United Kingdom 3597 - 1 / 692 - 0
  103. Guernsey, Crown Dependency 1 - 0 / 1 - 0
  104. Isle of Man, Crown Dependency 1 - 0 / 0 - 0
  105. Jersey, Crown Dependency 8 - 0 / 5 - 0
  106. United States of America 21449 - 87 / 0 - 0
  107. Uruguay 195 - 0 / 0 - 0
  108. Vanuatu 2 - 0 / 1 - 0
  109. Venezuela 153 - 0 / 18 - 0
  110. Viet Nam 63 - 0 / 7 - 0
  111. West Bank and Gaza Strip 9 - 0 / 1 - 0
  112. Yemen 6 - 0 / 0 - 0
  • Grand Total 59814 - 263 / 3947 - 25
  • Chinese Taipei has reported 61 confirmed cases of influenza A (H1N1) with 0 deaths. Cases from Chinese Taipei are included in the cumulative totals provided in the table above.
  • Cumulative and new figures are subject to revision
  • Abbreviations
    • UKOT: United Kingdom Overseas Territory
    • FOC: French Overseas Collectivity
    • OT: Overseas Territory
  • Netherlands Antilles, Curaçao *: 3 confirmed cases: The three confirmed cases are crew members of a cruise ship. They did not leave the boat during their illness nor during the 24 hours preceding the onset of symptoms.
-
WHO | Influenza A(H1N1) - update 54
Blogged with the Flock Browser

Hong Kong: HA update on Designated Flu Clinic and discharged human swine influenza patients (6/26/09)

The following is issued on behalf of the Hospital Authority: Regarding the services of the eight Designated Flu Clinics (DFCs) and the confirmed human swine influenza patients admitted to public hospitals, the Hospital Authority (HA) spokesman provided the following updates today (June 26):

The Designated Flu Clinics today (as at 5pm) provide treatment to a total of 270 patients.

The HA spokesman reminded the public that the eight DFCs have ceased the provision of general outpatient services.

Patients with other illnesses are advised to seek medical treatment at other general outpatient clinics in the district or private practitioners.

Chronic patients who have been pre-scheduled for follow up at the eight DFCs should proceed to their corresponding clinics with drug refill service according to their date of original appointment and bring along the appointment slip and Identity Card.

As at 2.30pm today, there were 90 newly confirmed cases of human swine influenza in the past 24 hours.

This brings to 596 the total number of confirmed human swine influenza cases in Hong Kong.

Among them, a total of 384 confirmed cases have been discharged from public hospitals upon recovery, the remaining cases in hospitals have been stable (none required intensive care and there were no fatal cases).

Besides, a paediatric patient of Queen Elizabeth Hospital (QEH) was among the confirmed cases that the Centre of Health Protection (CHP) reported today.

The 12 years old boy was admitted to the paediatric ward of QEH on June 22 due to flu symptoms and was discharged on June 24 upon recovery.

During his hospitalization, respiratory sample of the boy was taken for laboratory test on influenza as a routine surveillance. The CHP confirmed the positive result of human swine influenza test on his respiratory sample last night (June 25).

The boy has been admitted to QEH for treatment under isolation and is now in stable condition. QEH has completed the contact tracing of the other eight patients in the same cubicle of the ward. One boy was found to have presented with upper respiratory symptoms and he is now in stable condition. The ward staff are asymptomatic. HA Infection Control Guideline has been duly observed with surgical masks, gloves and protective gown during patient care. Full set of Personal Protective Equipment (including N95 respirator, face shields, gloves and protective gown) is required for high risk procedures. The Hospital and CHP will continue to closely monitor the situation.

Another confirmed case is a female Clinical Services Assistant in Hong Kong Buddhist Hospital (HKBH).She developed flu symptoms on June 20 and attended the Central Kowloon Health Centre (one of the DFCs) on June 21. She was prescribed Tamiflu and granted sick leave. CHP confirmed the case on June 25 evening. She is now under isolation treatment in QEH. One of her family members was found to be infected by human swine influenza earlier. She works in the Palliative Care Ward of HKBH. She follows the HA Infection Control Guidelines for patient care. She wears surgical mask when she is on duty. HKBH has traced the close contacts of the ward staff including patients and staff working in the ward. Up to the present moment, no patient or other staff was found to be infected by human swine influenza. We reassure the public that situation in hospital is under control. We will continue to follow the HA Infection Control Guideline and hygiene for patients and staff.
-

View Original Article

Blogged with the Flock Browser

Hong Kong: DH advises two secondary schools to suspend classes (6/26/09)

A spokesman for the Department of Health (DH) today (June 26) said that two secondary schools in Kowloon would suspend classes to stop the possible spread of human swine influenza (Influenza A H1N1) in the schools.

The advice was made following the confirmation of two human swine influenza cases in the schools.

The first case involved a 14-year-old girl, a Form Three student of Tak Oi Secondary School in Tsz Wan Shan. The girl attended school on June 24 when she he had onset of influenza symptoms.

The second case involved a 14-year-old girl, a Form Three student of Diocesan Girls' School. She had onset of influenza symptoms on June 24.

DH had advised the schools to start its summer break starting tomorrow. Both of the students are in stable condition. Investigations into the cases are ongoing.

The spokesman called on parents to pay attention to the health condition of their children, and to remind them to observe good personal and environmental hygiene.
-

View Original Article

Blogged with the Flock Browser

Hong Kong: Ninety new cases of human swine influenza (6/26/09)

A spokesman for the Department of Health said there had been 90 newly confirmed cases of human swine influenza (Influenza A H1N1) in the 24 hours to 2.30pm today (June 26).

This brings to 596 the total number of human swine influenza cases in Hong Kong.

The new cases involve 52 males and 38 females, aged between 6 and 70.
-

View Original Article

Blogged with the Flock Browser

USA. CDC H1N1 Flu, CDC H1N1 Flu Update: U.S. Human Cases of H1N1 Flu Infection (June 25, 2009, edited)

Novel H1N1 Flu Situation Update - June 25, 2009, 7:00 PM ET


Map: Weekly Influenza Activity Estimates Reported by State and Territorial Epidemiologists
(Activity levels indicate geographic spread of both seasonal and novel influenza A [H1N1] viruses)
(Posted June 19, 2009, 4:00 PM ET, for Week Ending June 13, 2009)

FluView, Week Ending June 13, 2009. Weekly Influenza Surveillance Report Prepared by the Influenza Division. Weekly Influenza Activity Estimate Reported by State and Territorial Epidemiologists. Select this link for more detailed data.
For more details about the data in the map above, see the FluView Surveillance Report for the week ending June 13, 2009. For information about how this map is updated, see Questions & Answers About CDC's Online Reporting.


Table. U.S. Human Cases of H1N1 Flu Infection

Web page updated June 25, 2009,7:00 PM ET to coincide with the Advisory Committee on Immunization Practices meeting
(Normally updated each Friday at 11 AM ET)
Data reported to CDC by June 25, 2009, 11:00 AM ET.

[States and Territories* - Confirmed and Probable Cases - Deaths]
  1. Alabama 239 cases - 0 deaths
  2. Alaska 46 cases - 0 deaths
  3. Arkansas 35 cases - 0 deaths
  4. Arizona 729 cases - 8 deaths
  5. California 1492 cases - 16 deaths
  6. Colorado 103 cases - 0 deaths
  7. Connecticut 877 cases - 5 deaths
  8. Delaware 267 cases - 0 deaths
  9. Florida 941 cases - 2 deaths
  10. Georgia 65 cases - 0 deaths
  11. Hawaii 465 cases - 0 deaths
  12. Idaho 72 cases - 0 deaths
  13. Illinois 2875 cases - 12 deaths
  14. Indiana 251 cases - 0 deaths
  15. Iowa 92 cases - 0 deaths
  16. Kansas 117 cases - 0 deaths
  17. Kentucky 119 cases - 0 deaths
  18. Louisiana 153 cases - 0 deaths
  19. Maine 61 cases - 0 deaths
  20. Maryland 414 cases - 1 death
  21. Massachusetts 1287 cases - 1 death
  22. Michigan 468 cases - 2 deaths
  23. Minnesota 537 cases - 1 death
  24. Mississippi 114 cases - 0 deaths
  25. Missouri 55 cases - 1 death
  26. Montana 44 cases - 0 deaths
  27. Nebraska 111 cases - 0 deaths
  28. Nevada 250 cases - 0 deaths
  29. New Hampshire 207 cases - 0 deaths
  30. New Jersey 899 cases - 6 deaths
  31. New Mexico 232 cases - 0 deaths
  32. New York 2272 cases - 35 deaths
  33. North Carolina 179 cases - 1 death
  34. North Dakota 48 cases - 0 deaths
  35. Ohio 93 cases - 0 deaths
  36. Oklahoma 123 cases - 1 death
  37. Oregon 289 cases - 3 deaths
  38. Pennsylvania 1483 cases - 3 deaths
  39. Rhode Island 132 cases - 1 death
  40. South Carolina 120 cases - 0 deaths
  41. South Dakota 22 cases - 0 deaths
  42. Tennessee 148 cases - 0 deaths
  43. Texas 2981 cases - 10 deaths
  44. Utah 874 cases - 10 deaths
  45. Vermont 46 cases - 0 deaths
  46. Virginia 191 cases - 1 death
  47. Washington 588 cases - 3 deaths
  48. Washington, D.C. 33 cases - 0 deaths
  49. West Virginia 114 cases - 0 deaths
  50. Wisconsin 4273 cases - 4 death
  51. Wyoming 72 cases - 0 deaths
  • Territories
  1. Puerto Rico 18 cases - 0 deaths
  2. Virgin Islands 1 case - 0 deaths
  • TOTAL (53)* 27,717 cases - 127 deaths
  • (*) Includes the District of Columbia, Puerto Rico and the U.S. Virgin Islands.
  • This table will be updated each Friday at 11 AM ET.

International Human Cases of H1N1 Flu Infection

See: World Health Organization.


NOTE: Because of daily reporting deadlines, the state totals reported by CDC may not always be consistent with those reported by state health departments. If there is a discrepancy between these two counts, data from the state health departments should be used as the most accurate number.

For more information about how these case counts are updated, see Questions & Answers About CDC's Online Reporting.


Summary of Situation

Updated June 11, 2009, 12:30 PM ETA


Pandemic Is Declared

On June 11, 2009, the World Health Organization (WHO) raised the worldwide pandemic alert level to Phase 6 in response to the ongoing global spread of the novel influenza A (H1N1) virus. A Phase 6 designation indicates that a global pandemic is underway.

More than 70 countries are now reporting cases of human infection with novel H1N1 flu. This number has been increasing over the past few weeks, but many of the cases reportedly had links to travel or were localized outbreaks without community spread. The WHO designation of a pandemic alert Phase 6 reflects the fact that there are now ongoing community level outbreaks in multiple parts of world.

WHO’s decision to raise the pandemic alert level to Phase 6 is a reflection of the spread of the virus, not the severity of illness caused by the virus. It’s uncertain at this time how serious or severe this novel H1N1 pandemic will be in terms of how many people infected will develop serious complications or die from novel H1N1 infection. Experience with this virus so far is limited and influenza is unpredictable. However, because novel H1N1 is a new virus, many people may have little or no immunity against it, and illness may be more severe and widespread as a result. In addition, currently there is no vaccine to protect against novel H1N1 virus.

In the United States, most people who have become ill with the newly declared pandemic virus have recovered without requiring medical treatment, however, CDC anticipates that there will be more cases, more hospitalizations and more deaths associated with this pandemic in the coming days and weeks. In addition, this virus could cause significant illness with associated hospitalizations and deaths in the fall and winter during the U.S. influenza season.


Background

Novel influenza A (H1N1) is a new flu virus of swine origin that first caused illness in Mexico and the United States in March and April, 2009. It’s thought that novel influenza A (H1N1) flu spreads in the same way that regular seasonal influenza viruses spread, mainly through the coughs and sneezes of people who are sick with the virus, but it may also be spread by touching infected objects and then touching your nose or mouth. Novel H1N1 infection has been reported to cause a wide range of flu-like symptoms, including fever, cough, sore throat, body aches, headache, chills and fatigue. In addition, many people also have reported nausea, vomiting and/or diarrhea.

The first novel H1N1 patient in the United States was confirmed by laboratory testing at CDC on April 15, 2009. The second patient was confirmed on April 17, 2009. It was quickly determined that the virus was spreading from person-to-person. On April 22, CDC activated its Emergency Operations Center to better coordinate the public health response. On April 26, 2009, the United States Government declared a public health emergency and has been actively and aggressively implementing the nation’s pandemic response plan.

Since the outbreak was first detected, an increasing number of U.S. states have reported cases of novel H1N1 influenza with associated hospitalizations and deaths. By June 3, 2009, all 50 states in the United States and the District of Columbia and Puerto Rico were reporting cases of novel H1N1 infection. While nationwide U.S. influenza surveillance systems indicate that overall influenza activity is decreasing in the country at this time, novel H1N1 outbreaks are ongoing in parts of the U.S., in some cases with intense activity.

CDC is continuing to watch the situation carefully, to support the public health response and to gather information about this virus and its characteristics. The Southern Hemisphere is just beginning its influenza season and the experience there may provide valuable clues about what may occur in the Northern Hemisphere this fall and winter.


CDC Response

CDC continues to take aggressive action to respond to the outbreak. CDC’s response goals are to reduce the spread and severity of illness, and to provide information to help health care providers, public health officials and the public address the challenges posed by this new public health threat.

CDC is issuing updated interim guidance in response to the rapidly evolving situation.


Clinician Guidance

CDC has issued interim guidance for clinicians on identifying and caring for patients with novel H1N1, in addition to providing interim guidance on the use of antiviral drugs. Influenza antiviral drugs are prescription medicines (pills, liquid or an inhaled powder) with activity against influenza viruses, including novel influenza H1N1 viruses. The priority use for influenza antiviral drugs during this outbreak is to treat people hospitalized with influenza illness, and to treat people at increased risk of severe illness, including pregnant women, young children, and people with chronic health conditions like asthma, diabetes and other metabolic diseases, heart or lung disease, kidney disease, weakened immune systems, and persons with neurologic or neuromuscular disease.


Public Guidance

CDC has provided guidance for the public on what to do if they become sick with flu-like symptoms, including infection with novel H1N1. CDC also has issued instructions on taking care of a sick person at home and the use of facemasks and respirators to reduce novel influenza A (H1n1) transmission. Everyone should take everyday preventive actions to stop the spread of germs, including frequent hand washing and people who are sick should stay home and avoid contact with others in order to limit further spread of the disease.


Testing

CDC has developed a PCR diagnostic test kit to detect this novel H1N1 virus and has now distributed test kits to all states in the U.S. and the District of Columbia and Puerto Rico. The test kits are being shipped internationally as well. This will allow states and other countries to test for this new virus.


Vaccine

Vaccines are a very important part of a response to pandemic influenza and the U.S. Government is aggressively taking early steps in the process to manufacture a novel H1N1 vaccine, working closely with manufacturers. CDC has isolated the new H1N1 virus, made a candidate vaccine virus that can be used to create vaccine, and has provided this virus to industry so they can begin scaling up for production of a vaccine, if necessary. Making vaccine is a long multi-step process requiring several months to complete.


Stockpile Deployment

CDC has deployed 25 percent of the supplies in the Strategic National Stockpile (SNS) to all states in the continental United States and U.S. territories. This included antiviral drugs, personal protective equipment, and respiratory protection devices. The influenza A (H1N1) virus is susceptible to the prescription antiviral drugs oseltamivir and zanamivir. These supplies and medicines will help states and U.S. territories respond to novel H1N1 virus.


Surveillance

Novel influenza A (H1N1) activity is now being detected through CDC’s routine influenza surveillance systems and reported weekly in FluView. CDC tracks U.S. influenza activity through multiple systems across five categories. While our influenza surveillance systems indicate that overall influenza activity is decreasing in the United States, novel H1N1 outbreaks are ongoing in different parts of the U.S., in some cases with intense influenza-like activity. Most of the influenza viruses being detected now are novel H1N1 viruses.


Shared Responsibility

Individuals have an important role in protecting themselves and their families.
  • Stay informed. Health officials will provide additional information as it becomes available.
  • Everyone should take these everyday steps to protect your health and lessen the spread of this new virus:
    • Cover your nose and mouth with a tissue when you cough or sneeze. Throw the tissue in the trash after you use it.
    • Wash your hands often with soap and water, especially after you cough or sneeze. Alcohol-based hand cleaners are also effective.
    • Avoid touching your eyes, nose or mouth. Germs spread this way.
    • Try to avoid close contact with sick people.
    • If you are sick with a flu-like illness, stay home for 7 days after your symptoms begin or until you have been symptom-free for 24 hours, whichever is longer. This is to keep from infecting others and spreading the virus further.
    • Follow public health advice regarding school closures, avoiding crowds and other social distancing measures.

More on the WHO Pandemic Declaration

More on the Situation
(...)
-
CDC H1N1 Flu | CDC H1N1 Flu Update: U.S. Human Cases of H1N1 Flu Infection
Blogged with the Flock Browser

H1N1 'swine' flu has infected an estimated 1 million in U.S. - Los Angeles Times

H1N1 'swine' flu has infected an estimated 1 million in U.S.Swine flu

By Thomas H. Maugh II
3:54 PM PDT, June 25, 2009


At least 1 million Americans have now contracted the novel H1N1 influenza, according to mathematical models prepared by the Centers for Disease Control and Prevention, while data from the field indicates that the virus is continuing to spread even though the normal flu season is over and that an increasing proportion of victims are being hospitalized.

Meanwhile, the virus is continuing its rapid spread through the Southern Hemisphere, infecting increasing numbers of people and at least one pig.

Nearly 28,000 laboratory-confirmed U.S. cases of the virus, also known as swine flu, have been reported to the CDC, almost half of the more than 56,000 cases globally reported to the World Health Organization.

But Lyn Finelli, a flu surveillance official with CDC, told a vaccine advisory committee meeting in Atlanta today that standard models of viral spread indicate that many times that number have been infected. Although 1 million seems like a high number, between 15 million and 60 million Americans are infected by the influenza virus during a normal flu season.

At least 3,065 of those infected in this country have been hospitalized and 127 have died. The very young are most likely to be infected, Finelli said, but older patients seem to suffer more. The average age of swine flu victims is 12, the average age of hospitalized patients is 20 and the average age of those who have died is 37, she said.

The normal seasonal flu virus has virtually disappeared from this country, as would be expected. But the novel H1N1 virus is continuing to spread, and now accounts for 98% of all cases.

"So far, it doesn't look like transmission is declining at all," Finelli said.

The spread is highest in New England and the Northeast, and it is beginning to take its toll. Dr. Andrew Doniger, director of public health for Monroe County, N.Y., which includes the city of Rochester, said hospitals, emergency rooms and laboratories in the county are being overwhelmed by "very high volumes" of patients. He called on those who have mild symptoms to self-medicate at home.

In the Southern Hemisphere, which is one month into its flu season, several countries, particularly Chile, Argentina and Australia, are already feeling the effects of the new virus. Chile has had more than 4,000 laboratory-confirmed cases and seven deaths, Argentina more than 1,200 cases and 17 deaths, and Australia 3,200 cases and three deaths.

In Argentina, the virus is spreading particularly rapidly in the conurbano, the densely populated working-class suburbs and slums that ring Buenos Aires. Hospitals in the area are postponing elective surgeries to have more beds available for flu patients, and the government is sending mobile clinics into many of the neighborhoods.

In Chile, emergency room visits have tripled and waiting times in public hospitals are seven hours or more.

Epidemiologists fear that the novel H1N1 virus may exchange genetic information with other flu viruses while it is working its way through the Southern Hemisphere and develop a greater pathogenicity when it returns to the north this fall, but so far that is not happening, said WHO director-general Dr. Margaret Chan. In a news conference in Moscow today, she said that "the virus is still very stable. . . . But we all know the influenza virus is highly unpredictable and has great potential for mutation."

One surprising victim of the virus is a pig in Argentina. Jorge Amaya, director of the animal health and sanitation service there, said that the animal had recovered and that other pigs were being tested for the virus. He said he thinks the pig caught it from a human.

That was the initial theory when researchers found the virus in a Canadian herd early in the pandemic, but subsequent tests of the virus showed that it was different from the one that had infected their caretaker. As of now, no one knows how the pigs became infected.

The U.S. Department of Agriculture has been monitoring pigs throughout this country for signs of the virus, but so far has reported no infections.

Some help for the upcoming winter flu season is on the way. The French pharmaceutical company Sanofi-Aventis said today that it had begun large-scale production of a vaccine against the novel H1N1 virus. The company did not say how many doses it was preparing, and noted that it was still producing seasonal flu vaccine for the Northern and Southern Hemispheres.

The company has the capacity to make 270 million doses of vaccine per year at its three plants, two in the United States and one in France. The novel H1N1 vaccine has to be tested before it can be used.

thomas.maugh@latimes.com
-
H1N1 'swine' flu has infected an estimated 1 million in U.S. - Los Angeles Times
Blogged with the Flock Browser

Latin America reports five more deaths, 1,062 new cases of A/H1N1 flu (Xinhua, edited)

Latin America reports five more deaths, 1,062 new cases of A/H1N1 flu

www.chinaview.cn 2009-06-26 11:12:07
MEXICO CITY, June 25 (Xinhua)


Five more deaths and 1,062 new cases of influenza A/H1N1 were confirmed in Latin America on Thursday.

The Guatemalan Health Ministry reported the first death in the country, but it did not mention new infections.

The Mexican Health Ministry reported three new deaths, raising the death toll to 119 in the country. There was a total of 9,028 confirmed cases with 749 new cases compared with the report on Tuesday.

Argentina's health authorities confirmed one more death, raising the total to 22 in the country. It reported a total of 1,391 confirmed cases with 178 new cases as against the last report on Tuesday night.

Brazil's Health Ministry confirmed 53 new cases of A/H1N1 flu in the country with the total number of cases swelling to 452.

The Peruvian Health Ministry reported 61 new cases, raising infections in that country to 360.

The Venezuelan National Institute of Hygiene reported 20 new cases of A/H1N1 flu, bringing the country's total infections to 172.

The Colombian Social Protection Ministry reported one more case, raising the confirmed number of cases to 73. There were two deaths in the country.
-
L America reports five more deaths, 1,062 new cases of A/H1N1 flu_English_Xinhua
Blogged with the Flock Browser

U.S. A/H1N1 flu death toll rises to 127(Xinhua, edited)

U.S. A/H1N1 flu death toll rises to 127

www.chinaview.cn 2009-06-26 12:05:51
HOUSTON, June 25 (Xinhua)


The A/H1N1 flu death toll in the United States has reached 127 with 27,717 confirmed and probable cases, the U.S. Centers for Disease Control and Prevention (CDC) reported on Thursday.

The CDC said that in the United States, most people who have become ill with the newly declared pandemic virus have recovered without requiring medical treatment.

However, the CDC anticipate that there will be more cases, more hospitalizations and more deaths associated with this new virus in the coming days and weeks.

In addition, this virus could cause significant illness with associated hospitalizations and deaths in the fall and winter during the U.S. influenza season.
-
U.S. A/H1N1 flu death toll rises to 127_English_Xinhua
Blogged with the Flock Browser

Texas death toll of A/H1N1 flu rises to 13, confirmed cases to 2,981 (Xinhua, edited)

Texas death toll of A/H1N1 flu rises to 13, confirmed cases to 2,981

www.chinaview.cn 2009-06-26 13:51:12
HOUSTON, June 25 (Xinhua)


Texas health authorities on Thursday reported three more deaths and 462 new cases of A/H1N1 flu virus, bringing the death toll to 13 and the total number of confirmed cases to 2,981 in the southwest U.S. state.

The Federal Centers for Disease Control and Prevention (CDC) on Thursday confirmed a total of 2,981 cases in Texas, but only 10 deaths of the A/H1N1 virus in the state.

The Department of State Health Services (DSHS) said that, due to reporting schedules, DSHS case and death counts usually will be higher and more current than those on the CDC website.

The DSHS also said the 2,981 cases of A/H1N1 flu have been confirmed in 95 of the state's 254 counties.

Nationwide, the CDC on Thursday reported combined 27,717 confirmed cases of A/H1N1 flu in the 50 states plus the District of Columbia and U.S. territory Puerto Rico and U.S. Virgin Islands, with 127 deaths in 22 states.
-
Texas death toll of A/H1N1 flu rises to 13, confirmed cases to 2,981_English_Xinhua
Blogged with the Flock Browser

Australia suffers fourth A/H1N1 flu death (Xinhua, edited)

Australia suffers fourth A/H1N1 flu death

www.chinaview.cn 2009-06-26 13:59:11
CANBERRA, June 26 (Xinhua)


Australia's official A/H1N1 flu death toll rose to four on Friday following the death of a 71-year-old Melbourne woman from the virus.

The woman's death was notified to the health department late on Thursday night, Victoria's acting chief health officer Rosemary Lester said. Her family requested that no details of her medical history be released.

Lester said A/H1N1 flu is generally mild, but can affect those with pre-existing medical conditions.

"It is important to remember that in the vast majority of cases,A/H1N1 flu is a mild illness which many people recover from without any medical treatment," she said in a statement.

"However, we know that for people with chronic medical conditions, influenza can be severe."

She advised high risk people, including those who are pregnant, have respiratory disease such as asthma, heart disease, diabetes, renal disease or obesity, should see their doctor if they have flu symptoms.

Victoria recorded 1,509 diagnosed cases of the virus, with many milder cases in the community that have not been tested, Lester revealed.
-
Australia suffers fourth A/H1N1 flu death _English_Xinhua
Blogged with the Flock Browser

Thailand's total number of A/H1N1 patients rises to 1,132 (Xinhua, edited)

Thailand's total number of A/H1N1 patients rises to 1,132

www.chinaview.cn 2009-06-26 14:17:13
BANGKOK, June 26 (Xinhua)


Thailand's Public Health Ministry on Friday announced 78 more patients, who are confirmed to have infected with the A/H1N1 flu virus, bringing the country's total number to 1,132.

Some 1,110 patients have already recovered, while the 22 others are still in hospitals, said Public Health Minister Witthaya Kaewparadai, the website by Thai language newspaper Krungthep Turakij reported.

Of the 22 patients, the condition of two critical patients: a 57-year-old woman and a naval student have improved. A respiratory machine was removed from the woman and she is able to breathe by herself, while the naval student has been released from an emergency unit, he said.

Thailand had its first two confirmed patients on May 12.

According to the World Health Organization, Thailand ranked as the 33rd country hit by the deadly new virus.
-
Thailand's total number of A/H1N1 patients rises to 1,132_English_Xinhua
Blogged with the Flock Browser

Philippines' A/H1N1 flu cases rise to 861 (Xinhua, edited)

Philippines' A/H1N1 flu cases rise to 861

www.chinaview.cn 2009-06-26 14:44:25
MANILA, June 26 (Xinhua)


Philippine health authorities reported 134 more cases of Influenza A/H1N1 on Friday, pushing the country's total to 861.

However, Health Secretary Francisco Duque said that all the newly-confirmed patients were "responding positively to their treatments."

A total of 634 patients -- or 74 percent of the total-- have fully recovered since May 21, he added.

The new cases involved 60 males and 74 females, said the health chief.

One hundred eighteen of the patients are Filipinos, and the remaining are foreigners.

Twenty of these cases have a history of travel to a country affected by the novel virus, he added.

Editor: Sun
-
Philippines' A/H1N1 flu cases rise to 861_English_Xinhua
Blogged with the Flock Browser

Australia. National tally of confirmed cases of H1N1 Influenza 09 - As at 5 am, 26 June 2009 (Dept. of Health, edited)

Australian Government - Department of Health and Ageing

National tally of confirmed cases of H1N1 Influenza 09 - As at 5 am, 26 June 2009

[Original Document: LINK. EDITED.]


The information contained in this situation report uses the most accurate currently available data.

Given the rapidly changing nature of the incident, recipients should be aware of the potential for later confirmation or clarification.


Current Australian confirmed cases of, and deaths associated with, H1N1 Influenza 09 (0600 AEST on 26 June 2009)

[Jurisdiction - Confirmed Cases - Deaths]

  • Australian Capital Territory - 127 - 0
  • New South Wales - 592 - 0
  • Northern Territory - 115 - 0
  • Queensland - 469 - 0
  • South Australia - 224 - 1
  • Tasmania - 67 - 0
  • Victoria - 1509 - 2
  • Western Australia - 177 - 0
  • Total - 3280 - 3
-
------
Blogged with the Flock Browser

Hong Kong: DH frontline services resume next Monday (6/26/09)

A spokesman for the Department of Health today (June 26) said the department's frontline services which had been suspended earlier this month to prevent the spread of human swine influenza (Influenza A H1N1) in the community would resume as normal from Monday (June 29).

The services involved are School Dental Care Service for primary students, Student Health Service for primary and secondary students, and Maternal and Child Services for children aged over 12 months.

The department would contact individual clients who had been affected by the closure for rescheduling of appointment, the spokesman said.

He reminded parents not to take along children not attending the services or other people to the department's service centres to avoid overcrowding and minimising the risk of infection.

"For newborn babies and children attending the maternal and child service, they should be accompanied by not more than two adults when entering the centre," the spokesman said.

As Shau Kei Wan Jockey Club Clinic, Kowloon Bay Health Centre and South Kwai Chung Jockey Club General Outpatient Clinic have been assigned as Designated Flu Clinics of the Hospital Authority, Shau Kei Wan Elderly Health Centre (EHC), Kowloon Bay Student Health Service Centre (SHSC) and South Kwai Chung SHSC in the respective complexes will continue to cease operation.

"Clients of Shau Kei Wan EHC can go to Wan Chai EHC for follow up and drug refills. Those of Kowloon Bay SHSC should go to Lam Tin SHSC at the time and date specified in their appointment letters while those of South Kwai Chung SHSC should attend the service at Western SHSC at the time and date specified in their appointment letters," the spokesman said.
-

View Original Article

Blogged with the Flock Browser

USA. CDC updates advice on antiviral treatment for flu (CIDRAP, edited)

CDC updates advice on antiviral treatment for flu

Lisa Schnirring * Staff Writer
Jun 25, 2009 (CIDRAP News)


The US Centers for Disease Control and Prevention (CDC) today at the Advisory Committee on Immunization Practices meeting in Atlanta issued updated guidelines for treatment of influenza, including novel H1N1, suggesting basing antiviral selection on laboratory test results when possible.

The new guidance appears to be aimed at preventing the inadvertent prescription of oseltamivir (Tamiflu) for seasonal H1N1 infections, which have shown extensive resistance to oseltamivir in the United States and other parts of the world. The update was provided by CDC spokesman Tom Skinner.

According to the CDC update, only patients who test positive for influenza A/H3N2, pandemic H1N1, or B should receive oseltamivir. Zanamivir (Relenza) is preferred for patients who test positive for seasonal H1N1 influenza.

If a laboratory test is not performed or the test is negative but clinical suspicion remains, the preferred treatment is zanamivir or a combination of oseltamivir and rimantadine, which is an older drug of the adamantine class of antivirals. If testing indicates influenza A or unspecified influenza, the preferred treatment is also zanamivir or a combination of oseltamivir and rimantadine.

As with its earlier recommendation for novel H1N1 treatment, the CDC emphasized in today's updated guidance that treatment should be started as soon as possible after illness onset.

The CDC added a few more specifics to the list of people for whom antiviral treatment should be considered to include those who are hospitalized with influenza, have influenza with viral or bacterial pneumonia, or have influenza with a higher risk for complications, regardless or illness severity.

Seasonal flu strains, which typically wane this time of year, account for only a small fraction of currently circulating strains, the CDC said on Jun 19 in its surveillance update for the week ending Jun 13. More than 98% of subtyped influenza A viruses reported to the CDC were pandemic H1N1 strains. Seasonal H1N1 and H3N2 each accounted for only 0.8% of the viruses.

Last December the CDC changed its guidance about flu treatment after noting increased resistance to oseltamivir, the leading influenza drug. The new guidance added adamantanes back into the recommendations, suggesting zanamivir or oseltamivir plus rimantadine for patients suspected of having seasonal influenza A infections.

See also:
May 6 CDC interim antiviral recommendations for patients with novel H1N1 infections and their contacts
Dec 19, 2008, CIDRAP News story "With H1N1 resistance, CDC changes advice on flu drugs"
CDC weekly influenza update
-
CIDRAP >> CDC updates advice on antiviral treatment for flu
Blogged with the Flock Browser